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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305332
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mdm2
Name: MDM2 proto-oncogene
Acc ID: CHEBI:27504
Term: mitomycin C
Definition: A mitomycin that has formula C15H18N4O5.
Chemical ID: MESH:D016685
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mdm2increases expressionISOMDM2 (Homo sapiens)6480464CTDMitomycin results in increased expression of MDM2 proteinPMID:18096571
Mdm2increases expressionISOMdm2 (Mus musculus)6480464CTDMitomycin results in increased expression of MDM2 mRNAPMID:25270620
Mdm2multiple interactionsISOMDM2 (Homo sapiens)6480464CTD[Mitomycin results in increased stability of TP53 protein] which results in increased expression of MDM2 mRNAPMID:20536192
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