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GENE - TERM ANNOTATION REPORT

RGD ID: 12608403
Species: Ictidomys tridecemlineatus
RGD Object: Gene
Symbol: Aqp4
Name: aquaporin 4
Acc ID: DOID:4724
Term: brain edema
Definition: A brain disease that is characterized by excess accumulation of fluid in the intracellular and/or extracellular spaces of the brain, has_symptom nausea, has_symptom vomiting, has_symptom blurred vision, has_symptom seizure, has_symptom coma. (DO)
Definition Source(s): https://en.wikipedia.org/wiki/Cerebral_edema "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aqp4 ISOAqp4 (Mus musculus)9068941RGD PMID:21187412 REF_RGD_ID:5148010
Aqp4 ISOAqp4 (Mus musculus)9068941RGDassociated with Drug-Induced Liver Injury;protein:increased expression:cerebral cortexPMID:20938728 REF_RGD_ID:5148020
Aqp4 ISOAqp4 (Rattus norvegicus)9068941RGDassociated with AnoxiaPMID:21560328 REF_RGD_ID:5148033
Aqp4 ISOAqp4 (Rattus norvegicus)9068941RGDassociated with Cerebral HemorrhagePMID:20541575 REF_RGD_ID:5490126
Aqp4 ISOAqp4 (Rattus norvegicus)9068941RGDassociated with Drug-Induced Liver Injury;protein:increased expression:cerebral cortex, astrocyte, plasma membranePMID:20720509 REF_RGD_ID:5490122
Aqp4 ISOAqp4 (Rattus norvegicus)9068941RGDassociated with Embolism, Fat;protein:increased expression:brainPMID:20111877 REF_RGD_ID:5490129
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