Aqp4 (aquaporin 4) - Rat Genome Database

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Gene: Aqp4 (aquaporin 4) Ictidomys tridecemlineatus
Analyze
Symbol: Aqp4
Name: aquaporin 4
RGD ID: 12608403
Description: ENCODES a protein that exhibits identical protein binding (ortholog); water channel activity (ortholog); INVOLVED IN carbon dioxide transport (ortholog); cell-cell adhesion (ortholog); cellular response to estradiol stimulus (ortholog); PARTICIPATES IN water transport pathway; ASSOCIATED WITH Alpers-Huttenlocher syndrome (ortholog); Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN astrocyte end-foot (ortholog); basal plasma membrane (ortholog); basolateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: aquaporin 4, transcript variant X1; aquaporin 4, transcript variant X2; aquaporin 4, transcript variant X3; aquaporin-4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494457,872,160 - 57,884,958 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365505,931,194 - 5,941,354 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365505,931,201 - 5,943,999 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Aqp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494457,872,160 - 57,884,958 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365505,931,194 - 5,941,354 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365505,931,201 - 5,943,999 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AQP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381826,852,038 - 26,865,803 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1826,852,043 - 26,865,771 (-)EnsemblGRCh38hg38GRCh38
GRCh371824,432,002 - 24,445,767 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361822,686,005 - 22,699,714 (-)NCBINCBI36Build 36hg18NCBI36
Build 341822,686,007 - 22,699,714NCBI
Celera1821,242,174 - 21,255,883 (-)NCBICelera
Cytogenetic Map18q11.2NCBI
HuRef1821,281,696 - 21,295,401 (-)NCBIHuRef
CHM1_11824,359,750 - 24,373,454 (-)NCBICHM1_1
T2T-CHM13v2.01827,046,091 - 27,059,856 (-)NCBIT2T-CHM13v2.0
Aqp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391815,522,451 - 15,544,039 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1815,522,553 - 15,544,039 (-)EnsemblGRCm39 Ensembl
GRCm381815,389,394 - 15,410,982 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1815,389,496 - 15,410,982 (-)EnsemblGRCm38mm10GRCm38
MGSCv371815,547,903 - 15,562,193 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361815,535,839 - 15,546,671 (-)NCBIMGSCv36mm8
Celera1815,609,213 - 15,623,487 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map188.74NCBI
Aqp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8186,782,389 - 6,799,034 (-)NCBIGRCr8
mRatBN7.2186,507,903 - 6,524,558 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl186,507,903 - 6,524,856 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx186,733,660 - 6,750,099 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0187,521,314 - 7,537,753 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,792,881 - 6,809,322 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0186,766,009 - 6,782,757 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl186,765,945 - 6,782,996 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0186,720,759 - 6,737,703 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4186,626,313 - 6,642,766 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1186,628,189 - 6,642,700 (-)NCBI
Celera186,530,014 - 6,546,446 (-)NCBICelera
RH 3.4 Map1878.3RGD
RH 3.4 Map1886.21RGD
Cytogenetic Map18p13NCBI
Aqp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049557721,159 - 10,709 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049557721,160 - 10,709 (+)NCBIChiLan1.0ChiLan1.0
AQP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21744,280,877 - 44,294,636 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11829,973,472 - 29,987,231 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01820,108,607 - 20,122,381 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11823,713,141 - 23,726,919 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1823,713,146 - 23,726,919 (-)Ensemblpanpan1.1panPan2
AQP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1761,855,617 - 61,868,953 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl761,855,744 - 61,865,089 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha761,290,817 - 61,304,150 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0761,906,422 - 61,919,761 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl761,906,451 - 61,926,075 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1761,579,168 - 61,592,459 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0761,591,530 - 61,604,873 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0761,894,861 - 61,908,198 (+)NCBIUU_Cfam_GSD_1.0
AQP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6111,407,639 - 111,422,109 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16111,407,632 - 111,422,169 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26104,387,592 - 104,394,409 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AQP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11853,729,143 - 53,742,916 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1853,729,186 - 53,743,156 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605028,456,973 - 28,470,756 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aqp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247705,580,808 - 5,594,628 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247705,581,192 - 5,593,470 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000013313   ⟹   ENSSTOP00000011934
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365505,935,357 - 5,941,354 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000038862   ⟹   ENSSTOP00000025786
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365505,931,194 - 5,940,987 (-)Ensembl
RefSeq Acc Id: XM_013360207   ⟹   XP_013215661
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494457,872,595 - 57,884,958 (+)NCBI
SpeTri2.0NW_0049365505,931,201 - 5,943,496 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021728932   ⟹   XP_021584607
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494457,872,160 - 57,884,958 (+)NCBI
SpeTri2.0NW_0049365505,931,201 - 5,943,999 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021728933   ⟹   XP_021584608
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494457,873,109 - 57,884,958 (+)NCBI
SpeTri2.0NW_0049365505,931,201 - 5,943,021 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040274179   ⟹   XP_040130113
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494457,872,314 - 57,884,958 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_013215661   ⟸   XM_013360207
- Peptide Label: isoform X2
- UniProtKB: A0A287CWX8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021584607   ⟸   XM_021728932
- Peptide Label: isoform X1
- UniProtKB: A0A287CWX8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021584608   ⟸   XM_021728933
- Peptide Label: isoform X2
- UniProtKB: A0A287CWX8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040130113   ⟸   XM_040274179
- Peptide Label: isoform X2
- UniProtKB: A0A287CWX8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000011934   ⟸   ENSSTOT00000013313
RefSeq Acc Id: ENSSTOP00000025786   ⟸   ENSSTOT00000038862


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000013318 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000013313.3 UniProtKB/TrEMBL
  ENSSTOT00000038862.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1080.10 UniProtKB/TrEMBL
InterPro Aquaporin-like UniProtKB/TrEMBL
  Aquaporin_transptr UniProtKB/TrEMBL
  MIP UniProtKB/TrEMBL
  MIP_CS UniProtKB/TrEMBL
NCBI Gene Aqp4 ENTREZGENE
PANTHER AQUAPORIN-4 UniProtKB/TrEMBL
  PTHR19139 UniProtKB/TrEMBL
Pfam MIP UniProtKB/TrEMBL
PRINTS AQUAPORIN4 UniProtKB/TrEMBL
  MINTRINSICP UniProtKB/TrEMBL
PROSITE MIP UniProtKB/TrEMBL
Superfamily-SCOP SSF81338 UniProtKB/TrEMBL
UniProt A0A287CWX8 ENTREZGENE, UniProtKB/TrEMBL
  I3MKS2_ICTTR UniProtKB/TrEMBL