GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Gclc | decreases activity | EXP | | 6480464 | CTD | Buthionine Sulfoximine results in decreased activity of GCLC protein | PMID:15707499 PMID:7955076 | Gclc | increases activity | EXP | | 6480464 | CTD | Buthionine Sulfoximine results in increased activity of GCLC protein | PMID:10915739 | Gclc | increases expression | EXP | | 6480464 | CTD | Buthionine Sulfoximine results in increased expression of GCLC mRNA | PMID:17980396 PMID:18449455 PMID:34036678 PMID:35123994 | Gclc | multiple interactions | EXP | | 6480464 | CTD | [Buthionine Sulfoximine results in decreased activity of GCLC protein] inhibits the reaction [indenoindole results in increased abundance of Glutathione]; [Buthionine Sulfoximine results in decreased activity of GCLC protein] which results in decreased abundance of Glutathione; [Thiabendazole co-treated with Buthionine Sulfoximine] results in increased activity of GCLC protein; Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased expression of GCLC mRNA]; Buthionine Sulfoximine inhibits the reaction [GCLC protein results in decreased susceptibility to naphthalene]; Buthionine Sulfoximine inhibits the reaction [Hypochlorous Acid results in increased expression of GCLC mRNA]; Buthionine Sulfoximine inhibits the reaction [naphthalene results in increased activity of GCLC protein]; Buthionine Sulfoximine promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of GCLC mRNA] | PMID:10900227 PMID:11019651 PMID:12805647 PMID:15707499 PMID:17980396 PMID:34036678 PMID:35123994 PMID:7955076 | Gclc | decreases activity | ISO | Gclc (Rattus norvegicus) | 6480464 | CTD | Buthionine Sulfoximine results in decreased activity of GCLC protein | PMID:12433058 | Gclc | decreases expression | ISO | GCLC (Homo sapiens) | 6480464 | CTD | Buthionine Sulfoximine results in decreased expression of GCLC protein | PMID:35298964 | Gclc | increases expression | ISO | Gclc (Rattus norvegicus) | 6480464 | CTD | Buthionine Sulfoximine results in increased expression of GCLC mRNA | PMID:10978506 PMID:23585199 | Gclc | multiple interactions | ISO | Gclc (Rattus norvegicus) | 6480464 | CTD | [Buthionine Sulfoximine co-treated with Carmustine] results in decreased activity of GCLC protein; [Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]; [Carmustine co-treated with Buthionine Sulfoximine] results in decreased activity of GCLC protein; Buthionine Sulfoximine inhibits the reaction [decamethrin results in increased expression of GCLC mRNA]; Buthionine Sulfoximine inhibits the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine]; Buthionine Sulfoximine inhibits the reaction [Microcystins analog results in increased expression of GCLC mRNA] | PMID:12967637 PMID:15115889 PMID:16288907 PMID:22864849 PMID:23585199 PMID:24964298 | Gclc | multiple interactions | ISO | GCLC (Homo sapiens) | 6480464 | CTD | Buthionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione]; Buthionine Sulfoximine inhibits the reaction [GCLC results in decreased susceptibility to Cadmium Chloride]; Buthionine Sulfoximine promotes the reaction [sodium arsenite results in decreased expression of GCLC protein] | PMID:17724089 PMID:18556457 PMID:35298964 | | ||||||||||||||||||||||
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