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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:folate cycle metabolic pathway
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Accession:PW:0001207 term browser browse the term
Definition:The folate cycle metabolic pathway sums up the uptake and transport of folates, the processing and interconversion reactions of folate compounds. The folate cycle and the folate mediate one-carbon transfer pathways are part of folate metabolism.
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show annotations for term's descendants           Sort by:
folate cycle metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1L1 aldehyde dehydrogenase 1 family member L1 ISO RGD PMID:22353665 RGD:7242562 NCBI chr 3:123,166,630...123,244,257
Ensembl chr 3:130,484,862...130,562,934 		JBrowse link
G AMT aminomethyltransferase ISO RGD PMID:20645850 RGD:7242560 NCBI chr 3:49,344,590...49,350,383
Ensembl chr 3:50,589,193...50,594,968 		JBrowse link
G DHFR dihydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 5:34,663,210...34,689,467
Ensembl chr 5:34,938,548...34,967,003 		JBrowse link
G DLD dihydrolipoamide dehydrogenase ISO RGD PMID:20645850 RGD:7242560 NCBI chr 7:99,872,020...99,901,884
Ensembl chr 7:112,593,934...112,623,629 		JBrowse link
G DMGDH dimethylglycine dehydrogenase ISO RGD PMID:20645850 RGD:7242560 NCBI chr 5:36,241,341...36,313,995
Ensembl chr 5:36,732,005...36,805,883 		JBrowse link
G FOLR2 folate receptor beta ISO RGD PMID:22108709 RGD:7242557 NCBI chr11:67,295,305...67,300,463
Ensembl chr11:70,518,931...70,524,088 		JBrowse link
G FPGS folylpolyglutamate synthase ISO RGD PMID:16859665 RGD:7242559 NCBI chr 9:98,921,986...98,933,542
Ensembl chr 9:127,593,592...127,604,200 		JBrowse link
G GCSH glycine cleavage system protein H ISO RGD PMID:20645850 RGD:7242560 NCBI chr16:61,688,959...61,702,364 JBrowse link
G GGH gamma-glutamyl hydrolase ISO RGD PMID:16859665 RGD:7242559 NCBI chr 8:59,547,821...59,571,523
Ensembl chr 8:61,222,194...61,246,252 		JBrowse link
G GLDC glycine decarboxylase ISO RGD PMID:20645850 RGD:7242560 NCBI chr 9:6,347,381...6,456,042
Ensembl chr 9:6,527,242...6,635,779 		JBrowse link
G LOC100994139 folate receptor alpha ISO RGD PMID:22108709 RGD:7242557 NCBI chr11:67,268,721...67,275,498
Ensembl chr11:70,492,039...70,498,665 		JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chr14:44,969,573...45,041,296
Ensembl chr14:63,223,484...63,293,881 		JBrowse link
G MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like ISO RGD PMID:22108709 RGD:7242557 NCBI chr 6:148,679,587...148,919,002
Ensembl chr 6:153,390,498...153,619,884 		JBrowse link
G MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase ISO RGD PMID:20645850 PMID:22108709 RGD:7242557 RGD:7242560 NCBI chr2A:74,270,161...74,285,790
Ensembl chr2A:75,777,028...75,792,699 		JBrowse link
G MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like ISO RGD PMID:22108709 RGD:7242557 NCBI chr 4:49,889,607...50,034,860
Ensembl chr 4:55,722,237...55,867,117 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 1:10,548,196...10,568,174
Ensembl chr 1:11,766,334...11,785,419 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 1:212,353,195...212,463,304
Ensembl chr 1:217,358,050...217,460,946 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 5:8,195,868...8,228,071
Ensembl chr 5:8,017,403...8,049,322 		JBrowse link
G SARDH sarcosine dehydrogenase ISO RGD PMID:20645850 RGD:7242560 NCBI chr 9:104,786,774...104,864,480
Ensembl chr 9:133,398,806...133,473,642 		JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chr17:32,870,949...32,905,690
Ensembl chr17:37,849,206...37,884,220 		JBrowse link
G SHMT2 serine hydroxymethyltransferase 2 ISO RGD PMID:20645850 PMID:22108709 RGD:7242557 RGD:7242560 NCBI chr12:31,692,451...31,697,727
Ensembl chr12:31,944,785...31,950,138 		JBrowse link
G SLC19A1 solute carrier family 19 member 1 ISO RGD PMID:20814827 PMID:22108709 RGD:7242426 RGD:7242557 NCBI chr21:31,836,774...31,883,829
Ensembl chr21:45,090,595...45,134,752 		JBrowse link
G SLC25A32 solute carrier family 25 member 32 ISO RGD PMID:22332074 RGD:7242561 NCBI chr 8:100,054,560...100,071,016
Ensembl chr 8:102,210,068...102,226,732 		JBrowse link
G SLC46A1 solute carrier family 46 member 1 ISO RGD PMID:20814827 PMID:22108709 RGD:7242426 RGD:7242557 NCBI chr17:28,367,674...28,379,618
Ensembl chr17:28,870,678...28,877,632 		JBrowse link
altered folate cycle metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1L1 aldehyde dehydrogenase 1 family member L1 ISO RGD PMID:22353665 RGD:7242562 NCBI chr 3:123,166,630...123,244,257
Ensembl chr 3:130,484,862...130,562,934 		JBrowse link
G DHFR dihydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 5:34,663,210...34,689,467
Ensembl chr 5:34,938,548...34,967,003 		JBrowse link
G LOC100994139 folate receptor alpha ISO RGD PMID:22108709 RGD:7242557 NCBI chr11:67,268,721...67,275,498
Ensembl chr11:70,492,039...70,498,665 		JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chr14:44,969,573...45,041,296
Ensembl chr14:63,223,484...63,293,881 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 1:10,548,196...10,568,174
Ensembl chr 1:11,766,334...11,785,419 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 1:212,353,195...212,463,304
Ensembl chr 1:217,358,050...217,460,946 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 5:8,195,868...8,228,071
Ensembl chr 5:8,017,403...8,049,322 		JBrowse link
G SLC46A1 solute carrier family 46 member 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chr17:28,367,674...28,379,618
Ensembl chr17:28,870,678...28,877,632 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4069
    classic metabolic pathway 1016
      metabolic pathway of cofactors, vitamins, nutrients 239
        folate metabolic pathway 31
          folate cycle metabolic pathway 24
            altered folate cycle metabolic pathway 8
Path 2
Term Annotations click to browse term
  pathway 4069
    regulatory pathway 2518
      homeostasis pathway 1306
        organic chemical homeostasis pathway 364
          S-adenosylmethionine homeostasis pathway 265
            folate metabolic pathway 31
              folate cycle metabolic pathway 24
                altered folate cycle metabolic pathway 8
paths to the root