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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:Parkinson's disease pathway
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Accession:PW:0000018 term browser browse the term
Definition:One of the most common neurodegenerative diseases that is characterized by the loss of dopaminergic neurons in the substantia nigra and the presence of cytoplasmic inclusions called Lewy bodies in surrounding neurons. Several pathways are thought to be deregulated; for instance, imbalance of iron homeostasis is believed to contribute to the pathogenesis of the condition.
Synonyms:exact_synonym: Parkinson disease pathway;   paralysis agitans pathway
 related_synonym: KEGG:05012
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Parkinson's disease pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp13a2 ATPase cation transporting 13A2 ISO RGD PMID:26223426 RGD:10450518 NCBI chrNW_004936474:3,968,216...3,980,821
Ensembl chrNW_004936474:3,968,506...3,980,815 		JBrowse link
G Dnajc13 DnaJ heat shock protein family (Hsp40) member C13 ISO RGD PMID:25701813 RGD:10450845 NCBI chrNW_004936529:5,768,229...5,883,841
Ensembl chrNW_004936529:5,785,538...5,883,097 		JBrowse link
G Dnajc6 DnaJ heat shock protein family (Hsp40) member C6 ISO RGD PMID:25302295 PMID:25639775 RGD:10450521 RGD:10450553 NCBI chrNW_004936692:2,788,477...2,836,094
Ensembl chrNW_004936692:2,741,632...2,834,078 		JBrowse link
G Fbxo7 F-box protein 7 ISO RGD PMID:26223426 RGD:10450518 NCBI chrNW_004936492:7,261,442...7,276,779
Ensembl chrNW_004936492:7,261,009...7,276,943 		JBrowse link
G Gba1 glucosylceramidase beta 1 ISO RGD PMID:25639775 PMID:26223426 RGD:10450518 RGD:10450521 NCBI chrNW_004936580:4,715,869...4,720,752
Ensembl chrNW_004936580:4,715,408...4,720,798 		JBrowse link
G Lrrk2 leucine rich repeat kinase 2 ISO RGD PMID:25639775 PMID:26223426 RGD:10450518 RGD:10450521 NCBI chrNW_004936607:628,469...761,117
Ensembl chrNW_004936607:626,991...761,123 		JBrowse link
G Maob monoamine oxidase B ISO RGD PMID:9129714 RGD:1358484 NCBI chrNW_004936502:9,907,181...10,014,756
Ensembl chrNW_004936502:9,907,180...10,014,773 		JBrowse link
G Nos1 nitric oxide synthase 1 ISO RGD PMID:11809160 RGD:1358519 NCBI chrNW_004936558:5,162,471...5,302,488
Ensembl chrNW_004936558:5,233,459...5,301,414 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4 group A member 2 ISO RGD PMID:11914402 RGD:1358553 NCBI chrNW_004936469:21,912,118...21,920,486
Ensembl chrNW_004936469:21,912,047...21,920,486 		JBrowse link
G Park7 Parkinsonism associated deglycase ISO RGD PMID:23766857 RGD:10450523 NCBI chrNW_004936623:2,422,780...2,436,817
Ensembl chrNW_004936623:2,422,833...2,436,817 		JBrowse link
G Pink1 PTEN induced kinase 1 ISO RGD PMID:24735649 PMID:25639775 PMID:26223426 RGD:10450518 RGD:10450521 RGD:10450527 NCBI chrNW_004936474:6,574,471...6,589,478
Ensembl chrNW_004936474:6,573,623...6,589,478 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO RGD PMID:14556719 PMID:24735649 PMID:25639775 PMID:26223426 RGD:10450518 RGD:10450521 RGD:10450527 RGD:1302872 NCBI chrNW_004936489:12,118,538...12,913,664
Ensembl chrNW_004936489:12,120,678...13,327,872 		JBrowse link
G Snca synuclein alpha ISO RGD PMID:12122208 PMID:25639775 PMID:26223426 PMID:26501339 RGD:10450517 RGD:10450518 RGD:10450521 RGD:730239 NCBI chrNW_004936685:2,077,017...2,175,298
Ensembl chrNW_004936685:2,076,651...2,175,338 		JBrowse link
G Synj1 synaptojanin 1 ISO RGD PMID:25302295 PMID:25639775 RGD:10450521 RGD:10450553 NCBI chrNW_004936500:9,484,571...9,565,980
Ensembl chrNW_004936500:9,484,586...9,566,100 		JBrowse link
G Vps35 VPS35 retromer complex component ISO RGD PMID:25619244 PMID:25639775 PMID:25701813 PMID:26223426 RGD:10450518 RGD:10450521 RGD:10450542 RGD:10450845 NCBI chrNW_004936475:50,476...77,797
Ensembl chrNW_004936475:50,321...78,097 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3951
    disease pathway 688
      nervous system disease pathway 434
        neurodegenerative pathway 41
          Parkinson's disease pathway 15
paths to the root