RGD Reference Report - Alphalpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's Disease. - Rat Genome Database

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Alphalpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's Disease.

Authors: Bobela, W  Aebischer, P  Schneider, BL 
Citation: Bobela W, etal., Biomolecules. 2015 Oct 16;5(4):2675-700. doi: 10.3390/biom5042675.
RGD ID: 10450517
Pubmed: PMID:26501339   (View Abstract at PubMed)
PMCID: PMC4693253   (View Article at PubMed Central)
DOI: DOI:10.3390/biom5042675   (Journal Full-text)

Accumulation and misfolding of the alpha-synuclein protein are core mechanisms in the pathogenesis of Parkinson's disease. While the normal function of alpha-synuclein is mainly related to the control of vesicular neurotransmission, its pathogenic effects are linked to various cellular functions, which include mitochondrial activity, as well as proteasome and autophagic degradation of proteins. Remarkably, these functions are also affected when the renewal of macromolecules and organelles becomes impaired during the normal aging process. As aging is considered a major risk factor for Parkinson's disease, it is critical to explore its molecular and cellular implications in the context of the alpha-synuclein pathology. Here, we discuss similarities and differences between normal brain aging and Parkinson's disease, with a particular emphasis on the nigral dopaminergic neurons, which appear to be selectively vulnerable to the combined effects of alpha-synuclein and aging.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Parkinson's disease  ISOSNCA (Homo sapiens)10450517; 10450517 RGD 

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Parkinson's disease pathway   TAS 10450517 RGD 
Parkinson's disease pathway   ISOSNCA (Homo sapiens)10450517; 10450517 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Snca  (synuclein alpha)

Genes (Mus musculus)
Snca  (synuclein, alpha)

Genes (Homo sapiens)
SNCA  (synuclein alpha)


Additional Information