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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal double-positive T cell morphology
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Accession:MP:0002408 term browser browse the term
Definition:any anomaly of the subset of T cells found in the thymus that express both CD4 and CD8
Comment:These cells are precursors to mature T cells and are generally located in the thymus; during their development, the alpha and beta chains of the T cell receptor are rearranged and the TCR receptor can be expressed.
Synonyms:exact_synonym: CD4+CD8+ T cell abnormalities;   double-positive T cell abnormalities


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decreased double-positive T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rag2 recombination activating 2 IMP RGD PMID:30206106 RGD:38508903 NCBI chr 3:87,902,373...87,910,227
Ensembl chr 3:87,902,238...87,911,066 		JBrowse link
increased double-positive T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase IMP RGD PMID:27895165 RGD:12879393 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Atmm1Kyo ATM serine/threonine kinase; ENU induced mutant 1, Kyo IMP RGD PMID:27895165 RGD:12879393
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5407
    immune system phenotype 502
      abnormal immune system morphology 194
        abnormal immune system development 21
          abnormal leukopoiesis 18
            abnormal lymphopoiesis 18
              abnormal T cell differentiation 18
                abnormal double-positive T cell morphology 9
                  decreased double-positive T cell number 6
                  increased double-positive T cell number 3
Path 2
Term Annotations click to browse term
  mammalian phenotype 5407
    hematopoietic system phenotype 250
      abnormal hematopoietic system morphology/development 230
        abnormal hematopoietic cell morphology 186
          abnormal blood cell morphology 99
            abnormal hemopoiesis 18
              abnormal definitive hematopoiesis 18
                abnormal leukopoiesis 18
                  abnormal lymphopoiesis 18
                    abnormal T cell differentiation 18
                      abnormal double-positive T cell morphology 9
                        decreased double-positive T cell number 6
                        increased double-positive T cell number 3
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