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ONTOLOGY REPORT - ANNOTATIONS

Term:transcription regulator inhibitor activity
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Accession:GO:0140416 term browser browse the term
Definition:A molecular function regulator that inhibits the activity of a transcription regulator via direct binding and/or post-translational modification.
Comment:Usage guidance: transcription regulator inhibitors bind to a transcription regulator to prevent it from reaching the chromatin. This activity does not occur at the promoter. For activities that do occur at the promoter, consider GO:0001217 ; DNA-binding transcription repressor activity or GO:0003714 ; transcription corepressor activity. An example of a transcription regulator is TCF23 Q7RTU1 is an example of a protein that regulates transcription factors by heterodimerising or binding to DbTFs and prevent DNA binding and their specific genomic binding site where the dbTF would have activated or repressed transcription. Also an example is NFKBIA P25963 which has a different way of regulating transcription factor activity by sequestering the dbTF (complex) in the cytoplasm. Another example is the HSP90 and HSP23 proteins that sequester steroid receptors away from the DNA.
Synonyms:narrow_synonym: DNA-binding transcription factor inhibitor activity


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transcription regulator inhibitor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DAXX death domain associated protein enables ISO (PMID:10698492), (PMID:15572661) GO_Central PMID:10698492 PMID:15572661 NCBI chr12:2,755,960...2,760,687
Ensembl chr12:2,755,960...2,761,340 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 enables IEA Ensembl GO_REF:0000107 NCBI chr10:1,606,693...1,612,410
Ensembl chr10:1,606,693...1,611,303 		JBrowse link
G DNAJB1 DnaJ heat shock protein family (Hsp40) member B1 enables IEA Ensembl GO_REF:0000107 NCBI chr20:48,120,604...48,131,091
Ensembl chr20:48,121,379...48,130,060 		JBrowse link
G HEXIM1 HEXIM P-TEFb complex subunit 1 enables ISO (PMID:14580347) HGNC-UCL PMID:14580347 NCBI chr 9:18,384,811...18,387,981 JBrowse link
G HSP70 heat shock protein 70 enables ISO (PMID:9499401) GO_Central PMID:9499401 NCBI chr12:1,285,282...1,287,670 JBrowse link
G ID1 inhibitor of DNA binding 1 enables IEA Ensembl GO_REF:0000107 NCBI chr24:21,094,339...21,096,276
Ensembl chr24:21,094,755...21,096,276 		JBrowse link
G ID3 inhibitor of DNA binding 3 enables ISO (MGI:4821067|PMID:17681138) UniProt PMID:17681138 MGI:4821067 NCBI chr 2:75,880,659...75,881,786
Ensembl chr 2:75,880,657...75,882,010 		JBrowse link
G ID4 inhibitor of DNA binding 4, HLH protein enables IEA Ensembl GO_REF:0000107 NCBI chr35:18,358,518...18,360,767
Ensembl chr35:18,357,826...18,359,011
Ensembl chr35:18,357,826...18,359,011 		JBrowse link
G KIAA1586 KIAA1586 ortholog enables IEA Ensembl GO_REF:0000107
G LEF1 lymphoid enhancer binding factor 1 enables IEA Ensembl GO_REF:0000107 NCBI chr32:28,516,002...28,633,759
Ensembl chr32:28,517,108...28,634,019 		JBrowse link
G LOC102151783 inhibitor of DNA binding 2 enables ISO (MGI:1934945|PMID:10652346), (MGI:4821067|PMID:17681138) UniProt PMID:10652346 PMID:17681138 MGI:1934945 MGI:4821067 NCBI chr10:54,954,852...54,957,116 JBrowse link
G LOC480840 uncharacterized LOC480840 enables ISO (PMID:11134351) UniProt PMID:11134351 NCBI chr  X:10,128,169...10,140,386
Ensembl chr  X:10,128,849...10,140,351 		JBrowse link
G LYAR Ly1 antibody reactive enables ISO (PMID:31413131) ARUK-UCL PMID:31413131 NCBI chr 3:69,710,735...69,724,175
Ensembl chr 3:69,710,735...69,724,177 		JBrowse link
G NFIB nuclear factor I B enables ISO (PMID:9099724) GO_Central PMID:9099724 NCBI chr11:34,573,136...35,010,319
Ensembl chr11:34,579,431...34,901,322 		JBrowse link
G NFKBIA NFKB inhibitor alpha enables IEA Ensembl GO_REF:0000107 NCBI chr 8:14,100,203...14,103,453
Ensembl chr 8:14,100,671...14,103,433 		JBrowse link
G NFKBIL1 NFKB inhibitor like 1 enables IEA Ensembl GO_REF:0000107 NCBI chr12:1,048,393...1,057,458
Ensembl chr12:1,049,109...1,057,237 		JBrowse link
G NKX3-1 NK3 homeobox 1 enables IEA Ensembl GO_REF:0000107 NCBI chr25:33,815,343...33,817,465
Ensembl chr25:33,815,095...33,817,474 		JBrowse link
G NR0B2 nuclear receptor subfamily 0 group B member 2 enables IEA Ensembl GO_REF:0000107 NCBI chr 2:73,234,482...73,236,548
Ensembl chr 2:73,234,586...73,236,206 		JBrowse link
G PASD1 PAS domain containing repressor 1 enables ISO (PMID:25936801) GO_Central PMID:25936801 NCBI chr  X:119,536,333...119,629,452
Ensembl chr  X:119,536,268...119,629,451 		JBrowse link
G PKD1 polycystin 1, transient receptor potential channel interacting enables ISO (MGI:5315699|PMID:16311606) BHF-UCL PMID:16311606 MGI:5315699 NCBI chr 6:38,811,051...38,865,503
Ensembl chr 6:38,837,964...38,865,503 		JBrowse link
G PKD2 polycystin 2, transient receptor potential cation channel enables IEA Ensembl GO_REF:0000107 NCBI chr32:11,383,441...11,437,603
Ensembl chr32:11,383,424...11,435,438 		JBrowse link
G PURA purine rich element binding protein A enables IEA Ensembl GO_REF:0000107 NCBI chr 2:35,325,630...35,345,366
Ensembl chr 2:35,330,902...35,332,835 		JBrowse link
G SIN3A SIN3 transcription regulator family member A enables IEA Ensembl GO_REF:0000107 NCBI chr30:38,231,844...38,306,665
Ensembl chr30:38,232,680...38,382,635 		JBrowse link
G SMAD6 SMAD family member 6 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr30:30,938,908...31,014,259
Ensembl chr30:30,937,849...31,014,583 		JBrowse link
G SMAD7 SMAD family member 7 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:79,706,485...79,734,673
Ensembl chr 7:79,706,705...79,734,749 		JBrowse link
G SNIP1 Smad nuclear interacting protein 1 enables IEA Ensembl GO_REF:0000107 NCBI chr15:4,924,035...4,934,565
Ensembl chr15:4,924,178...4,933,724 		JBrowse link
G TAF1 TATA-box binding protein associated factor 1 enables ISO (PMID:24289924) ParkinsonsUK-UCL PMID:24289924 NCBI chr  X:55,693,091...55,764,268
Ensembl chr  X:55,693,194...55,763,683 		JBrowse link
G TAF3 TATA-box binding protein associated factor 3 enables IEA Ensembl GO_REF:0000107 NCBI chr 2:28,121,719...28,298,961
Ensembl chr 2:28,122,649...28,298,946 		JBrowse link
G TCF23 transcription factor 23 enables IEA Ensembl GO_REF:0000107 NCBI chr17:21,139,408...21,145,014
Ensembl chr17:21,140,794...21,144,053 		JBrowse link
G UACA uveal autoantigen with coiled-coil domains and ankyrin repeats enables ISO (PMID:14961764) MGI PMID:14961764 NCBI chr30:34,376,072...34,467,278
Ensembl chr30:34,376,077...34,467,206 		JBrowse link
G ZNF451 zinc finger protein 451 enables IEA Ensembl GO_REF:0000107 NCBI chr12:24,260,862...24,350,890
Ensembl chr12:24,260,917...24,350,559 		JBrowse link
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Term Annotations click to browse term
  molecular_function 18798
    molecular function regulator activity 1950
      molecular function inhibitor activity 474
        transcription regulator inhibitor activity 31
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