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ONTOLOGY REPORT - ANNOTATIONS

Term:gamma-secretase complex
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Accession:GO:0070765 term browser browse the term
Definition:A protein complex that has aspartic-type endopeptidase activity and contains a presenilin catalytic subunit (either PSEN1 or PSEN2), an APH1 subunit (multiple genes and splice variants exist), nicastrin (NCT), and presenilin enhancer (aka PEN-2 or Psenen), as the core complex. Variants of the complex with different subunit compositions differ in localization and specific substrates. Additionally, variants of the complex exist that contain a additional regulatory subunit as well as the four core subunits; known regulatory subunits include gamma-secretase-activating protein (aka gSAP), TMP1 (aka TMED10), and CD147 antigen (aka basigin). Gamma-secretase cleaves type I transmembrane protein substrates, including the cell surface receptor Notch and the amyloid-beta precursor protein.
Synonyms:exact_synonym: presenilin complex
 narrow_synonym: CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant);   PS1 complex;   PS2 complex;   gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant);   gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN);   gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN)
 related_synonym: gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN)


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gamma-secretase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APH1A aph-1 homolog A, gamma-secretase subunit located_in
part_of		 ISO
IEA		 (PMID:26280335) ComplexPortal
TreeGrafter
UniProt
Ensembl		 PMID:26280335 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:125,610,649...125,614,261
Ensembl chr 1:129,262,002...129,265,810 		JBrowse link
G APH1B aph-1 homolog B, gamma-secretase subunit part_of IEA Ensembl
TreeGrafter
UniProt		 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr15:42,224,593...42,256,202
Ensembl chr15:60,520,031...60,551,599 		JBrowse link
G NCSTN nicastrin located_in
part_of		 ISO
IEA		 (PMID:26280335) ComplexPortal
Ensembl		 PMID:26280335 GO_REF:0000107 NCBI chr 1:135,697,592...135,713,293
Ensembl chr 1:139,618,229...139,633,911 		JBrowse link
G PSEN1 presenilin 1 part_of IEA Ensembl GO_REF:0000107 NCBI chr14:53,718,299...53,802,684
Ensembl chr14:72,579,024...72,663,876 		JBrowse link
G PSEN2 presenilin 2 part_of IEA Ensembl GO_REF:0000107 NCBI chr 1:202,328,987...202,354,440
Ensembl chr 1:207,320,937...207,346,295 		JBrowse link
G PSENEN presenilin enhancer, gamma-secretase subunit located_in
part_of		 ISO
IEA		 (PMID:26280335) ComplexPortal
TreeGrafter
Ensembl		 PMID:26280335 GO_REF:0000107 GO_REF:0000118 NCBI chr19:32,675,331...32,677,285
Ensembl chr19:41,409,662...41,411,089 		JBrowse link
G TMED10 transmembrane p24 trafficking protein 10 part_of ISO
IEA		 RGD
Ensembl		 PMID:19754663 GO_REF:0000107 RGD:2317342 NCBI chr14:55,683,121...55,728,365
Ensembl chr14:74,526,733...74,572,000 		JBrowse link
Term paths to the root
Path 1
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  cellular_component 17179
    protein-containing complex 5908
      catalytic complex 1706
        gamma-secretase complex 7
Path 2
Term Annotations click to browse term
  cellular_component 17179
    cellular anatomical entity 16965
      membrane 8102
        plasma membrane 4667
          plasma membrane protein complex 578
            gamma-secretase complex 7
paths to the root