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ONTOLOGY REPORT - ANNOTATIONS

Term:peroxiredoxin activity
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Accession:GO:0051920 term browser browse the term
Definition:Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.
Comment:Includes redox chemistry as part of the catalytic reaction (2 R'-SH = R'-S-S-R'), where R' refers to peroxiredoxin itself). Not to be confused with GO:0004601 (peroxidase activity, EC:1.11.1.7), which has a different reaction mechanism.
Synonyms:exact_synonym: PRDX activity;   Prx activity
 xref: RHEA:10008;   reactome:R-HSA-1222431 "Peroxynitrite is reduced to nitrite by AhpC";   reactome:R-HSA-1222755 "Peroxynitrite is reduced to nitrite by Tpx";   reactome:R-HSA-1500804 "Peroxynitrite is reduced by AhpE"


show annotations for term's descendants           Sort by:
peroxiredoxin activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENSRNOG00000062500 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr 6:119,379,144...119,379,952 JBrowse link
G ENSRNOG00000063007 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr 2:26,603,247...26,603,846 JBrowse link
G ENSRNOG00000066051 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr20:32,238,545...32,239,613 JBrowse link
G ENSRNOG00000066549 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr10:53,609,400...53,611,103 JBrowse link
G Park7 Parkinsonism associated deglycase enables ISO MGI:3514165 (PMID:17766438) RGD PMID:17766438 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Prdx1 peroxiredoxin 1 IDA RGD PMID:7488219 PMID:11350800 RGD:2291801, RGD:2291832 NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856 		JBrowse link
G Prdx3 peroxiredoxin 3 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111 		JBrowse link
G Prdx4 peroxiredoxin 4 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr  X:40,026,762...40,044,066
Ensembl chr  X:40,026,651...40,044,066 		JBrowse link
G Prdx6 peroxiredoxin 6 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355 		JBrowse link
thioredoxin peroxidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prdx1 peroxiredoxin 1 enables ISO
IBA		 (PMID:18606987)
GO_REF:0000033		 RGD
GO_Central		 PMID:18606987 GO_REF:0000033 NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856 		JBrowse link
G Prdx1l1 peroxiredoxin 1-like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:193,602,142...193,603,085
Ensembl chr 2:193,602,121...193,603,084 		JBrowse link
G Prdx2 peroxiredoxin 2 enables ISO
IBA
IEA		 (PMID:8144038)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:8144038 GO_REF:0000033 GO_REF:0000107 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194 		JBrowse link
G Prdx3 peroxiredoxin 3 enables ISO
IBA
IEA		 (PMID:21850687)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:21850687 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111 		JBrowse link
G Prdx4 peroxiredoxin 4 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:40,026,762...40,044,066
Ensembl chr  X:40,026,651...40,044,066 		JBrowse link
G Prdx5 peroxiredoxin 5 enables ISO
IBA
IEA		 (PMID:15280035)
GO_REF:0000033
GO_REF:0000002
(PMID:10751410)		 RGD
GO_Central
InterPro		 PMID:10751410 PMID:15280035 GO_REF:0000002 GO_REF:0000033 NCBI chr 1:204,099,826...204,103,589
Ensembl chr 1:204,099,826...204,114,268 		JBrowse link
G Selenof selenoprotein F IDA RGD PMID:11344099 RGD:728803 NCBI chr 2:233,642,075...233,674,853
Ensembl chr 2:233,641,932...233,674,846 		JBrowse link
thioredoxin-dependent peroxiredoxin activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prdx5 peroxiredoxin 5 enables ISO (MGI:7434529|PMID:10679306) RGD PMID:10679306 MGI:7434529 NCBI chr 1:204,099,826...204,103,589
Ensembl chr 1:204,099,826...204,114,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20486
    antioxidant activity 93
      peroxidase activity 64
        peroxiredoxin activity 13
          NADH-dependent peroxiredoxin activity 0
          thioredoxin-dependent peroxiredoxin activity + 7
Path 2
Term Annotations click to browse term
  molecular_function 20486
    catalytic activity 6038
      oxidoreductase activity 852
        oxidoreductase activity, acting on peroxide as acceptor 66
          peroxidase activity 64
            peroxiredoxin activity 13
              NADH-dependent peroxiredoxin activity 0
              thioredoxin-dependent peroxiredoxin activity + 7
paths to the root