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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of insulin secretion
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Accession:GO:0046676 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.
Synonyms:exact_synonym: down regulation of insulin secretion;   downregulation of insulin secretion
 narrow_synonym: inhibition of insulin secretion

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negative regulation of insulin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 involved_in ISO (PMID:16924481)
(PMID:25771886)		 RGD
MGI		 PMID:15163199 PMID:16924481 PMID:25771886 RGD:1598646 NCBI chrNW_004955414:32,216,243...32,289,028
Ensembl chrNW_004955414:32,216,196...32,289,053 		JBrowse link
G Acvr1c activin A receptor type 1C acts_upstream_of_or_within ISO (PMID:18480258) MGI PMID:18480258 NCBI chrNW_004955449:15,814,230...15,864,747
Ensembl chrNW_004955449:15,813,856...15,858,537 		JBrowse link
G Adra2a adrenoceptor alpha 2A involved_in ISO (PMID:10952463)
(PMID:1898674)
(PMID:17992256), (PMID:1898674)		 BHF-UCL
MGI		 PMID:1898674 PMID:10952463 PMID:17992256 NCBI chrNW_004955485:384,405...387,332
Ensembl chrNW_004955485:385,800...387,240 		JBrowse link
G Ccn3 cellular communication network factor 3 involved_in ISO (MGI:5517610|PMID:23705021) UniProt PMID:23705021 MGI:5517610 NCBI chrNW_004955417:25,218,613...25,225,755 JBrowse link
G Drd2 dopamine receptor D2 ISO RGD PMID:18216393 RGD:2311570 NCBI chrNW_004955412:15,054,255...15,114,558
Ensembl chrNW_004955412:15,054,038...15,114,573 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISO (PMID:17992256) MGI PMID:17992256 NCBI chrNW_004955425:24,050,901...24,054,039 JBrowse link
G Fam3d FAM3 metabolism regulating signaling molecule D involved_in ISO (PMID:12160727) UniProt PMID:12160727 NCBI chrNW_004955430:1,541,896...1,569,391
Ensembl chrNW_004955430:1,541,751...1,571,654 		JBrowse link
G Fbn1 fibrillin 1 involved_in ISO (MGI:6442875|PMID:30997682) UniProt PMID:30997682 MGI:6442875 NCBI chrNW_004955409:5,281,603...5,502,547
Ensembl chrNW_004955409:5,281,603...5,504,761 		JBrowse link
G Ffar3 free fatty acid receptor 3 involved_in ISO (PMID:25581519)
(PMID:26091414), (PMID:32073900)		 MGI PMID:25581519 PMID:26091414 PMID:32073900 NCBI chrNW_004955468:4,627,686...4,634,499 JBrowse link
G Foxo1 forkhead box O1 involved_in ISO (MGI:2388494|PMID:12219087), (MGI:6101624|PMID:27457971) UniProt PMID:12219087 PMID:27457971 MGI:2388494 MGI:6101624 NCBI chrNW_004955431:5,797,359...5,890,758 JBrowse link
G Ghrl ghrelin and obestatin prepropeptide acts_upstream_of_or_within ISO PMID:17130496
(PMID:17130496)		 MGI PMID:17130496 RGD:8553721 NCBI chrNW_004955561:1,676,475...1,682,205
Ensembl chrNW_004955561:1,676,576...1,681,812 		JBrowse link
G Ghsr growth hormone secretagogue receptor acts_upstream_of_or_within ISO PMID:17130496 MGI PMID:17130496 RGD:8553721 NCBI chrNW_004955420:2,483,173...2,486,414
Ensembl chrNW_004955420:2,478,877...2,487,215 		JBrowse link
G Gnao1 G protein subunit alpha o1 involved_in ISO (PMID:20622165) MGI PMID:20622165 NCBI chrNW_004955433:14,004,813...14,170,631
Ensembl chrNW_004955433:14,004,813...14,172,707 		JBrowse link
G Gnaz G protein subunit alpha z involved_in ISO (PMID:18096703) MGI PMID:18096703 NCBI chrNW_004955455:7,501,153...7,554,235
Ensembl chrNW_004955455:7,501,153...7,554,235 		JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase ISO RGD PMID:17491019 RGD:2302227 NCBI chrNW_004955496:1,835,034...1,861,410
Ensembl chrNW_004955496:1,835,034...1,861,407 		JBrowse link
G Hdac1 histone deacetylase 1 ISO RGD PMID:22772764 RGD:9590127 NCBI chrNW_004955452:10,636,366...10,668,873
Ensembl chrNW_004955452:10,636,366...10,670,864 		JBrowse link
G Inhbb inhibin subunit beta B acts_upstream_of_or_within ISO (PMID:18480258) MGI PMID:18480258 NCBI chrNW_004955459:9,482,998...9,488,489
Ensembl chrNW_004955459:9,482,873...9,488,489 		JBrowse link
G Irs1 insulin receptor substrate 1 involved_in ISO (PMID:15572028)
PMID:12435589		 BHF-UCL PMID:12435589 PMID:15572028 RGD:729325 NCBI chrNW_004955453:7,685,715...7,742,262
Ensembl chrNW_004955453:7,685,715...7,742,262 		JBrowse link
G Kcnb1 potassium voltage-gated channel subfamily B member 1 involved_in ISO (MGI:3770494|PMID:17767909) UniProt PMID:17767909 MGI:3770494 NCBI chrNW_004955445:8,680,979...8,779,662
Ensembl chrNW_004955445:8,680,965...8,774,110 		JBrowse link
G Kcnj11 potassium inwardly rectifying channel subfamily J member 11 involved_in ISO (PMID:8923010)
(PMID:16924481)
(PMID:33196462)		 BHF-UCL
MGI		 PMID:8923010 PMID:16924481 PMID:33196462 NCBI chrNW_004955414:32,209,426...32,212,424
Ensembl chrNW_004955414:32,210,545...32,211,717 		JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 ISO RGD PMID:16133261 RGD:1581603 NCBI chrNW_004955422:14,212,563...14,544,556
Ensembl chrNW_004955422:14,212,553...14,544,556 		JBrowse link
G Midn midnolin acts_upstream_of_or_within ISO PMID:24187134 MGI PMID:24187134 RGD:8655525 NCBI chrNW_004955495:6,651,331...6,661,846 JBrowse link
G Mtnr1a melatonin receptor 1A ISO RGD PMID:22288848 RGD:9686057 NCBI chrNW_004955403:22,636,212...22,658,566
Ensembl chrNW_004955403:22,636,212...22,658,566 		JBrowse link
G Mtnr1b melatonin receptor 1B ISO RGD PMID:18363673 RGD:9588673 NCBI chrNW_004955414:1,394,709...1,406,990
Ensembl chrNW_004955414:1,394,923...1,407,217 		JBrowse link
G Nos1 nitric oxide synthase 1 ISO RGD PMID:17130471 RGD:1642149 NCBI chrNW_004955455:13,797,557...13,978,402
Ensembl chrNW_004955455:13,797,545...13,972,566 		JBrowse link
G Npff neuropeptide FF-amide peptide precursor ISO RGD PMID:1704109 RGD:2316580 NCBI chrNW_004955458:799,072...799,745
Ensembl chrNW_004955458:799,072...799,745 		JBrowse link
G Pde8b phosphodiesterase 8B ISO RGD PMID:17991719 RGD:2312519 NCBI chrNW_004955425:23,512,865...23,614,326
Ensembl chrNW_004955425:23,512,151...23,635,697 		JBrowse link
G Pfkl phosphofructokinase, liver type acts_upstream_of_or_within ISO (PMID:9287040) MGI PMID:9287040 NCBI chrNW_004955407:41,131,022...41,145,392
Ensembl chrNW_004955407:41,131,022...41,145,394 		JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha involved_in ISO PMID:19965390 BHF-UCL PMID:19965390 RGD:2316628 NCBI chrNW_004955496:6,934,542...7,059,745
Ensembl chrNW_004955496:6,908,224...7,059,816 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase acts_upstream_of_or_within ISO (PMID:24187134) MGI PMID:24187134 NCBI chrNW_004955439:18,664,230...19,953,358
Ensembl chrNW_004955439:18,664,379...19,951,152 		JBrowse link
G Psmd9 proteasome 26S subunit, non-ATPase 9 involved_in ISO PMID:16099819 BHF-UCL PMID:16099819 RGD:8554418 NCBI chrNW_004955482:6,555,902...6,567,481
Ensembl chrNW_004955482:6,554,607...6,567,481 		JBrowse link
G Ptger3 prostaglandin E receptor 3 ISO RGD PMID:10531320 RGD:10043332 NCBI chrNW_004955423:21,096,926...21,164,435 JBrowse link
G Ptpn11 protein tyrosine phosphatase non-receptor type 11 acts_upstream_of_or_within ISO (PMID:15520383) MGI PMID:15520383 NCBI chrNW_004955482:8,934,734...9,031,230
Ensembl chrNW_004955482:8,934,306...9,035,203 		JBrowse link
G Rptor regulatory associated protein of MTOR complex 1 involved_in ISO (MGI:5619445|PMID:23092880) CACAO PMID:23092880 MGI:5619445 NCBI chrNW_004955506:2,009,422...2,401,775
Ensembl chrNW_004955506:2,008,044...2,401,775 		JBrowse link
G Sfrp1 secreted frizzled related protein 1 involved_in ISO (PMID:17994217) UniProt PMID:17994217 NCBI chrNW_004955536:1,663,721...1,702,678
Ensembl chrNW_004955536:1,663,344...1,703,514 		JBrowse link
G Sirt4 sirtuin 4 involved_in
acts_upstream_of_or_within		 ISO (PMID:17715127)
(PMID:16959573)		 UniProt
MGI		 PMID:16959573 PMID:17715127 NCBI chrNW_004955455:11,322,812...11,334,786
Ensembl chrNW_004955455:11,324,479...11,334,817 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 acts_upstream_of_or_within ISO (PMID:16890542) MGI PMID:16890542 NCBI chrNW_004955577:171,425...183,669
Ensembl chrNW_004955577:171,425...186,046 		JBrowse link
G Stxbp5l syntaxin binding protein 5L acts_upstream_of_or_within ISO (PMID:21998599) MGI PMID:21998599 NCBI chrNW_004955427:20,390,060...20,760,043
Ensembl chrNW_004955427:20,390,060...20,760,043 		JBrowse link
G Sytl4 synaptotagmin like 4 acts_upstream_of_or_within ISO (PMID:16890542) MGI PMID:16890542 NCBI chrNW_004955503:6,821,263...6,899,983
Ensembl chrNW_004955503:6,821,236...6,899,983 		JBrowse link
G Uts2 urotensin 2 ISO RGD PMID:17931748 RGD:2306798 NCBI chrNW_004955486:5,052,045...5,056,610
Ensembl chrNW_004955486:5,052,045...5,056,610 		JBrowse link
G Vsnl1 visinin like 1 acts_upstream_of_or_within ISO (PMID:16731532) MGI PMID:16731532 NCBI chrNW_004955469:350,983...454,264
Ensembl chrNW_004955469:350,983...454,264 		JBrowse link
negative regulation of insulin secretion involved in cellular response to glucose stimulus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A involved_in ISO (PMID:19965390) BHF-UCL PMID:19965390 RGD:2316628 NCBI chrNW_004955485:384,405...387,332
Ensembl chrNW_004955485:385,800...387,240 		JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 ISO RGD PMID:17360501 RGD:2306172 NCBI chrNW_004955410:31,830,333...31,874,384
Ensembl chrNW_004955410:31,828,506...31,875,100 		JBrowse link
G Eny2 ENY2 transcription and export complex 2 subunit ISO RGD PMID:22649445 RGD:9590329 NCBI chrNW_004955417:16,750,563...16,760,839
Ensembl chrNW_004955417:16,750,579...16,760,839 		JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B acts_upstream_of_or_within ISO (PMID:19805579) MGI PMID:19805579 NCBI chrNW_004955469:6,263,271...6,274,823
Ensembl chrNW_004955469:6,263,271...6,277,767 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase ISO RGD PMID:20610886 RGD:5508687 NCBI chrNW_004955425:25,362,165...25,380,611
Ensembl chrNW_004955425:25,359,884...25,380,745 		JBrowse link
G Jagn1 jagunal homolog 1 ISO RGD PMID:26882284 RGD:11520872 NCBI chrNW_004955561:1,388,592...1,392,107
Ensembl chrNW_004955561:1,388,592...1,392,107 		JBrowse link
G Klf7 KLF transcription factor 7 involved_in ISO (PMID:16339272) UniProt PMID:16339272 NCBI chrNW_004955457:7,833,711...7,918,754
Ensembl chrNW_004955457:7,833,218...7,918,754 		JBrowse link
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 ISO RGD PMID:19690174 RGD:7495848 NCBI chrNW_004955470:7,334,050...7,470,751
Ensembl chrNW_004955470:7,333,351...7,470,751 		JBrowse link
G Ndufaf2 NADH:ubiquinone oxidoreductase complex assembly factor 2 acts_upstream_of_or_within ISO (PMID:22587331) MGI PMID:22587331 NCBI chrNW_004955446:7,345,467...7,439,885 JBrowse link
G Pde1c phosphodiesterase 1C ISO RGD PMID:18706893 RGD:2302857 NCBI chrNW_004955410:32,790,720...33,257,760
Ensembl chrNW_004955410:32,792,649...33,257,291 		JBrowse link
G Pde3b phosphodiesterase 3B ISO RGD PMID:18706893 RGD:2302857 NCBI chrNW_004955414:29,783,999...29,911,329
Ensembl chrNW_004955414:29,783,963...29,909,685 		JBrowse link
G Pde4c phosphodiesterase 4C ISO RGD PMID:18706893 RGD:2302857 NCBI chrNW_004955524:3,199,534...3,218,013
Ensembl chrNW_004955524:3,200,486...3,218,618 		JBrowse link
G Pde8b phosphodiesterase 8B ISO RGD PMID:18706893 RGD:2302857 NCBI chrNW_004955425:23,512,865...23,614,326
Ensembl chrNW_004955425:23,512,151...23,635,697 		JBrowse link
G Pim3 Pim-3 proto-oncogene, serine/threonine kinase involved_in ISO (MGI:5294526|PMID:21099329) UniProt PMID:21099329 MGI:5294526 NCBI chrNW_004955413:33,068,033...33,071,344 JBrowse link
G Ptpmt1 protein tyrosine phosphatase mitochondrial 1 ISO RGD PMID:20167843 RGD:12904047 NCBI chrNW_004955422:723,236...724,761 JBrowse link
G Tbc1d1 TBC1 domain family member 1 ISO RGD PMID:28177704 RGD:150521607 NCBI chrNW_004955443:9,045,312...9,270,617
Ensembl chrNW_004955443:9,046,946...9,258,989 		JBrowse link
G Ucp2 uncoupling protein 2 ISO RGD PMID:21172424 RGD:7204422 NCBI chrNW_004955414:17,592,914...17,596,477
Ensembl chrNW_004955414:17,592,914...17,596,477 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12352
    negative regulation of biological process 4707
      negative regulation of transport 456
        negative regulation of protein transport 133
          negative regulation of protein secretion 87
            negative regulation of insulin secretion 56
              negative regulation of insulin secretion involved in cellular response to glucose stimulus 17
Path 2
Term Annotations click to browse term
  biological_process 12352
    localization 4280
      establishment of localization 3617
        transport 3343
          nitrogen compound transport 1354
            amide transport 369
              peptide transport 322
                peptide secretion 318
                  peptide hormone secretion 311
                    insulin secretion 249
                      regulation of insulin secretion 211
                        negative regulation of insulin secretion 56
                          negative regulation of insulin secretion involved in cellular response to glucose stimulus 17
paths to the root