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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of cholesterol biosynthetic process
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Accession:GO:0045540 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.
Synonyms:exact_synonym: regulation of cholesterol anabolism;   regulation of cholesterol biosynthesis;   regulation of cholesterol formation;   regulation of cholesterol synthesis


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regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 NOT|involved_in ISO (PMID:21810484) ARUK-UCL PMID:21810484 NCBI chr 9:48,610,906...48,630,932
Ensembl chr 9:48,613,996...48,629,857 		JBrowse link
G APOB apolipoprotein B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16455790) Ensembl
MGI		 PMID:16455790 GO_REF:0000107 NCBI chr17:15,877,937...15,916,032
Ensembl chr17:15,878,244...15,915,135 		JBrowse link
G AQP8 aquaporin 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:20,984,868...20,992,647
Ensembl chr 6:20,984,908...20,992,524 		JBrowse link
G DHCR7 7-dehydrocholesterol reductase ISO RGD PMID:10329655 RGD:632010 NCBI chr18:47,257,750...47,277,436
Ensembl chr18:47,261,730...47,274,236 		JBrowse link
G ERLIN1 ER lipid raft associated 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:12,924,942...12,962,016
Ensembl chr28:12,927,018...12,961,983 		JBrowse link
G ERLIN2 ER lipid raft associated 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:27,622,549...27,639,807
Ensembl chr16:27,625,417...27,639,202 		JBrowse link
G LPCAT3 lysophosphatidylcholine acyltransferase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:38,028,438...38,068,854
Ensembl chr27:38,028,120...38,068,502 		JBrowse link
G PEX2 peroxisomal biogenesis factor 2 acts_upstream_of_or_within ISO (PMID:14673138) MGI PMID:14673138 NCBI chr29:24,943,563...24,960,834 JBrowse link
G SCAP SREBF chaperone involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16054043) Ensembl
MGI
TreeGrafter		 PMID:16054043 GO_REF:0000107 GO_REF:0000118 NCBI chr20:41,418,507...41,485,681
Ensembl chr20:41,418,536...41,487,024 		JBrowse link
negative regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E involved_in ISO (PMID:1917954) RGD
BHF-UCL		 PMID:1917954 PMID:9225228 RGD:10059686 NCBI chr 1:110,525,717...110,528,534
Ensembl chr 1:110,525,722...110,528,440 		JBrowse link
G ERLIN1 ER lipid raft associated 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:12,924,942...12,962,016
Ensembl chr28:12,927,018...12,961,983 		JBrowse link
G ERLIN2 ER lipid raft associated 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:27,622,549...27,639,807
Ensembl chr16:27,625,417...27,639,202 		JBrowse link
G MIR185 microRNA mir-185 acts_upstream_of ISO (PMID:24296663)
(PMID:23951060)		 BHF-UCL PMID:23951060 PMID:24296663 NCBI chr26:29,296,014...29,296,069
Ensembl chr26:29,296,004...29,296,079 		JBrowse link
G MIR342 microRNA mir-342 acts_upstream_of ISO (PMID:23951060) BHF-UCL PMID:23951060 NCBI chr 8:68,424,656...68,424,718 JBrowse link
G MIR98 microRNA mir-98 involved_in ISO (PMID:30195495) BHF-UCL PMID:30195495 NCBI chr  X:45,253,693...45,253,772
Ensembl chr  X:45,253,696...45,253,775 		JBrowse link
G SOD1 superoxide dismutase 1 involved_in ISO (PMID:15473258) UniProt PMID:15473258 NCBI chr31:26,540,291...26,544,212
Ensembl chr31:26,486,274...26,662,815 		JBrowse link
positive regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCG1 ATP binding cassette subfamily G member 1 involved_in ISO (MGI:3768186|PMID:17916878) BHF-UCL PMID:17916878 MGI:3768186 NCBI chr31:36,574,406...36,627,598
Ensembl chr31:36,553,380...36,620,043 		JBrowse link
G ABCG4 ATP binding cassette subfamily G member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:14,707,964...14,720,782
Ensembl chr 5:14,707,960...14,721,240 		JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 involved_in ISO PMID:23536474 BHF-UCL PMID:23536474 RGD:13792517 NCBI chr29:9,285,315...9,295,895
Ensembl chr29:9,286,181...9,332,310 		JBrowse link
G FDPS farnesyl diphosphate synthase ISO RGD PMID:18637708 RGD:2316295 NCBI chr 7:42,241,086...42,250,373
Ensembl chr 7:42,241,107...42,250,225 		JBrowse link
G FGF1 fibroblast growth factor 1 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:37,467,431...37,554,770
Ensembl chr 2:37,470,985...37,554,619 		JBrowse link
G LOC477539 SEC14-like protein 2 ISO RGD PMID:11226224 RGD:727312 NCBI chr26:23,542,555...23,563,579 JBrowse link
G MIR96 microRNA mir-96 involved_in
acts_upstream_of		 ISO (PMID:23823476)
(PMID:30460077)		 BHF-UCL PMID:23823476 PMID:30460077 NCBI chr14:7,068,754...7,068,842
Ensembl chr14:7,068,754...7,068,842 		JBrowse link
G NPY1R neuropeptide Y receptor Y1 ISO RGD PMID:32976883 RGD:405096663 NCBI chr15:59,580,546...59,587,753
Ensembl chr15:59,580,809...59,583,237 		JBrowse link
G POR cytochrome p450 oxidoreductase ISO RGD PMID:19264869 RGD:2316785 NCBI chr 6:7,247,780...7,316,282
Ensembl chr 6:7,263,574...7,316,297 		JBrowse link
G QKI QKI, KH domain containing RNA binding involved_in ISO (MGI:6712091|PMID:33942715) UniProt PMID:33942715 MGI:6712091 NCBI chr 1:51,800,294...51,956,891
Ensembl chr 1:51,800,309...51,952,714 		JBrowse link
G SCAP SREBF chaperone involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:41,418,507...41,485,681
Ensembl chr20:41,418,536...41,487,024 		JBrowse link
G SCP2 sterol carrier protein 2 ISO RGD PMID:2554812 RGD:9850260 NCBI chr 5:55,860,053...55,971,657
Ensembl chr 5:55,860,549...55,964,014 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9329978)
(PMID:16046411)		 Ensembl
MGI		 PMID:9329978 PMID:16046411 GO_REF:0000107 NCBI chr 5:41,663,809...41,686,764
Ensembl chr 5:41,663,773...41,686,776 		JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:23,451,923...23,532,765
Ensembl chr10:23,452,561...23,518,689
Ensembl chr10:23,452,561...23,518,689 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17919
    regulation of biological process 12084
      regulation of metabolic process 6413
        regulation of small molecule metabolic process 376
          regulation of alcohol biosynthetic process 56
            regulation of cholesterol biosynthetic process 27
              negative regulation of cholesterol biosynthetic process 7
              positive regulation of cholesterol biosynthetic process 14
Path 2
Term Annotations click to browse term
  biological_process 17919
    biological regulation 12448
      regulation of biological process 12084
        regulation of metabolic process 6413
          regulation of primary metabolic process 5234
            regulation of lipid metabolic process 369
              regulation of lipid biosynthetic process 214
                regulation of steroid biosynthetic process 86
                  regulation of sterol biosynthetic process 27
                    regulation of cholesterol biosynthetic process 27
                      negative regulation of cholesterol biosynthetic process 7
                      positive regulation of cholesterol biosynthetic process 14
paths to the root