SCP2 (sterol carrier protein 2) - Rat Genome Database

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Gene: SCP2 (sterol carrier protein 2) Canis lupus familiaris
Analyze
Symbol: SCP2
Name: sterol carrier protein 2
RGD ID: 12314764
Description: ENCODES a protein that exhibits acetyl-CoA C-acyltransferase activity (ortholog); acetyl-CoA C-myristoyltransferase activity (ortholog); cholesterol transfer activity (ortholog); INVOLVED IN bile acid metabolic process (ortholog); cellular response to cholesterol (ortholog); fatty acid beta-oxidation (ortholog); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; ASSOCIATED WITH dystonia (ortholog); Experimental Diabetes Mellitus (ortholog); leukodystrophy (ortholog); FOUND IN endoplasmic reticulum (ortholog); peroxisomal matrix (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: non-specific lipid-transfer protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1555,860,053 - 55,971,657 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl555,860,549 - 55,964,014 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha555,925,974 - 56,029,762 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0556,049,398 - 56,153,726 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl556,049,398 - 56,153,708 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1556,041,491 - 56,145,154 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0555,932,897 - 56,036,796 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0556,322,159 - 56,425,975 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
SCP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1555,860,053 - 55,971,657 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl555,860,549 - 55,964,014 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha555,925,974 - 56,029,762 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0556,049,398 - 56,153,726 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl556,049,398 - 56,153,708 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1556,041,491 - 56,145,154 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0555,932,897 - 56,036,796 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0556,322,159 - 56,425,975 (-)NCBIUU_Cfam_GSD_1.0
SCP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38152,927,276 - 53,051,698 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl152,927,276 - 53,051,698 (+)EnsemblGRCh38hg38GRCh38
GRCh37153,392,948 - 53,517,370 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36153,165,536 - 53,289,870 (+)NCBINCBI36Build 36hg18NCBI36
Build 34153,104,968 - 53,229,303NCBI
Celera151,680,710 - 51,805,264 (+)NCBICelera
Cytogenetic Map1p32.3NCBI
HuRef151,508,548 - 51,632,772 (+)NCBIHuRef
CHM1_1153,510,076 - 53,634,447 (+)NCBICHM1_1
T2T-CHM13v2.0152,808,787 - 52,933,201 (+)NCBIT2T-CHM13v2.0
Scp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394107,901,027 - 108,002,168 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4107,901,036 - 108,002,195 (-)EnsemblGRCm39 Ensembl
GRCm384108,043,830 - 108,144,971 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4108,043,839 - 108,144,998 (-)EnsemblGRCm38mm10GRCm38
MGSCv374107,716,444 - 107,791,104 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364107,541,771 - 107,616,433 (-)NCBIMGSCv36mm8
Celera4106,393,462 - 106,469,326 (-)NCBICelera
Cytogenetic Map4C7NCBI
cM Map450.2NCBI
Scp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85128,035,714 - 128,110,015 (-)NCBIGRCr8
mRatBN7.25122,806,949 - 122,881,259 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5122,776,549 - 122,881,287 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5125,426,714 - 125,500,816 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05127,149,765 - 127,223,865 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05127,201,077 - 127,275,181 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05127,647,934 - 127,735,703 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5127,620,274 - 127,735,739 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05131,495,401 - 131,584,291 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45129,152,836 - 129,230,401 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15129,158,061 - 129,235,617 (-)NCBI
Celera5121,551,168 - 121,624,570 (-)NCBICelera
Cytogenetic Map5q34NCBI
Scp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554646,094,758 - 6,224,287 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554646,097,241 - 6,224,287 (-)NCBIChiLan1.0ChiLan1.0
SCP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21173,786,509 - 173,915,204 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11172,927,259 - 173,057,399 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0152,195,491 - 52,324,227 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1153,797,256 - 53,924,939 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl153,797,254 - 53,924,939 (+)Ensemblpanpan1.1panPan2
Scp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505867,305,291 - 67,411,787 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365228,005,442 - 8,110,889 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365228,004,503 - 8,110,995 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.16159,191,045 - 159,314,985 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26147,007,365 - 147,077,789 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SCP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12079,868,825 - 79,993,906 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2079,865,332 - 79,993,835 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603337,285,653 - 37,412,244 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Scp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624859107,258 - 252,756 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624859106,405 - 252,870 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SCP2
971 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 10 6
Low 8
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000046744   ⟹   ENSCAFP00000041481
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl555,860,549 - 55,964,014 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000091004   ⟹   ENSCAFP00000054579
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl555,860,549 - 55,964,014 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845032173   ⟹   ENSCAFP00845025151
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl556,049,398 - 56,153,708 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845032277   ⟹   ENSCAFP00845025231
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl556,049,398 - 56,153,708 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845032428   ⟹   ENSCAFP00845025354
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl556,049,398 - 56,153,708 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845032550   ⟹   ENSCAFP00845025455
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl556,060,283 - 56,153,708 (-)Ensembl
RefSeq Acc Id: XM_038476342   ⟹   XP_038332270
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1556,041,491 - 56,145,154 (-)NCBI
RefSeq Acc Id: XM_038476343   ⟹   XP_038332271
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1556,041,491 - 56,144,648 (-)NCBI
RefSeq Acc Id: XM_038521201   ⟹   XP_038377129
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha555,925,974 - 56,029,258 (-)NCBI
RefSeq Acc Id: XM_038537506   ⟹   XP_038393434
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0556,322,159 - 56,425,975 (-)NCBI
RefSeq Acc Id: XM_038601656   ⟹   XP_038457584
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0555,932,897 - 56,036,796 (-)NCBI
RefSeq Acc Id: XM_038601657   ⟹   XP_038457585
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0555,932,897 - 56,036,298 (-)NCBI
RefSeq Acc Id: XM_038666224   ⟹   XP_038522152
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0556,049,398 - 56,153,726 (-)NCBI
RefSeq Acc Id: XM_038666225   ⟹   XP_038522153
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0556,049,398 - 56,153,215 (-)NCBI
RefSeq Acc Id: XM_860991   ⟹   XP_866084
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1555,860,053 - 55,964,043 (-)NCBI
Dog10K_Boxer_Tasha555,925,974 - 56,029,762 (-)NCBI
Sequence:
RefSeq Acc Id: XP_866084   ⟸   XM_860991
- Peptide Label: isoform X1
- UniProtKB: A0A8I3S339 (UniProtKB/TrEMBL),   A0A8P0SVD2 (UniProtKB/TrEMBL),   A0A8C0MHY6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000041481   ⟸   ENSCAFT00000046744
RefSeq Acc Id: ENSCAFP00000054579   ⟸   ENSCAFT00000091004
RefSeq Acc Id: XP_038332270   ⟸   XM_038476342
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038332271   ⟸   XM_038476343
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038457584   ⟸   XM_038601656
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038457585   ⟸   XM_038601657
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038522152   ⟸   XM_038666224
- Peptide Label: isoform X1
- UniProtKB: A0A8I3S339 (UniProtKB/TrEMBL),   A0A8P0SVD2 (UniProtKB/TrEMBL),   A0A8C0MHY6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038522153   ⟸   XM_038666225
- Peptide Label: isoform X2
- UniProtKB: A0A8C0KHL0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038377129   ⟸   XM_038521201
- Peptide Label: isoform X2
- UniProtKB: A0A8C0KHL0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038393434   ⟸   XM_038537506
- Peptide Label: isoform X2
- UniProtKB: A0A8C0KHL0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845025455   ⟸   ENSCAFT00845032550
RefSeq Acc Id: ENSCAFP00845025231   ⟸   ENSCAFT00845032277
RefSeq Acc Id: ENSCAFP00845025354   ⟸   ENSCAFT00845032428
RefSeq Acc Id: ENSCAFP00845025151   ⟸   ENSCAFT00845032173
Promoters
RGD ID:13683326
Promoter ID:EPDNEW_C1394
Type:multiple initiation site
Name:SCP2_1
Description:sterol carrier protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1555,964,023 - 55,964,083EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000032423 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030004467 UniProtKB/TrEMBL
  ENSCAFG00845018123 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000046744.3 UniProtKB/TrEMBL
  ENSCAFT00000091004.2 UniProtKB/TrEMBL
  ENSCAFT00000106706.1 UniProtKB/TrEMBL
  ENSCAFT00000107346.1 UniProtKB/TrEMBL
  ENSCAFT00030008317.1 UniProtKB/TrEMBL
  ENSCAFT00030008503.1 UniProtKB/TrEMBL
  ENSCAFT00030008555.1 UniProtKB/TrEMBL
  ENSCAFT00845032173 ENTREZGENE
  ENSCAFT00845032173.1 UniProtKB/TrEMBL
  ENSCAFT00845032277.1 UniProtKB/TrEMBL
  ENSCAFT00845032428.1 UniProtKB/TrEMBL
  ENSCAFT00845032550.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1050.10 UniProtKB/TrEMBL
  3.40.47.10 UniProtKB/TrEMBL
InterPro SCP2_sterol-bd_dom UniProtKB/TrEMBL
  SCP2_sterol-bd_dom_sf UniProtKB/TrEMBL
  Thiolase-like UniProtKB/TrEMBL
  Thiolase_acyl_enz_int_AS UniProtKB/TrEMBL
  Thiolase_C UniProtKB/TrEMBL
  Thiolase_CS UniProtKB/TrEMBL
  Thiolase_N UniProtKB/TrEMBL
NCBI Gene SCP2 ENTREZGENE
PANTHER ACETYL-COA C-ACETYLTRANSFERASE UniProtKB/TrEMBL
  NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2 UniProtKB/TrEMBL
Pfam SCP2 UniProtKB/TrEMBL
  Thiolase_C UniProtKB/TrEMBL
  Thiolase_N UniProtKB/TrEMBL
PROSITE THIOLASE_1 UniProtKB/TrEMBL
  THIOLASE_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF53901 UniProtKB/TrEMBL
  SSF55718 UniProtKB/TrEMBL
UniProt A0A8C0KHL0 ENTREZGENE
  A0A8C0M7D8_CANLF UniProtKB/TrEMBL
  A0A8C0MB70_CANLF UniProtKB/TrEMBL
  A0A8C0MHY6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NVG8_CANLF UniProtKB/TrEMBL
  A0A8I3NVS7_CANLF UniProtKB/TrEMBL
  A0A8I3P3Q7_CANLF UniProtKB/TrEMBL
  A0A8I3S339 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PI36_CANLF UniProtKB/TrEMBL
  A0A8P0SVD2 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:45930 ENTREZGENE