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ONTOLOGY REPORT - ANNOTATIONS

Term:error-prone translesion synthesis
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Accession:GO:0042276 term browser browse the term
Definition:The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites.
Synonyms:exact_synonym: mutagenic PRR
 related_synonym: error-prone postreplication DNA repair;   mutagenic postreplication DNA repair


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error-prone translesion synthesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mad2l2 mitotic arrest deficient 2 like 2 involved_in ISO (PMID:24449906) RGD PMID:24449906 NCBI chr 5:158,563,545...158,576,698
Ensembl chr 5:158,563,567...158,576,693 		JBrowse link
G Pold2 DNA polymerase delta 2, accessory subunit involved_in ISO
IEA		 (PMID:24449906)
GO_REF:0000107		 RGD
Ensembl		 PMID:24449906 GO_REF:0000107 NCBI chr14:80,748,971...80,755,188
Ensembl chr14:80,748,974...80,755,160 		JBrowse link
G Pold3 DNA polymerase delta 3, accessory subunit involved_in ISO (PMID:24449906) RGD PMID:24449906 NCBI chr 1:154,417,893...154,456,687
Ensembl chr 1:154,418,084...154,456,665 		JBrowse link
G Pole2 DNA polymerase epsilon 2, accessory subunit involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:87,674,702...87,712,723
Ensembl chr 6:87,674,702...87,699,305 		JBrowse link
G Polh DNA polymerase eta involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:14,778,355...14,813,210
Ensembl chr 9:14,777,888...14,812,723 		JBrowse link
G Polk DNA polymerase kappa involved_in ISO
IBA		 (PMID:28297716)
GO_REF:0000033		 RGD
GO_Central		 PMID:28297716 GO_REF:0000033 NCBI chr 2:27,822,228...27,882,331
Ensembl chr 2:27,822,679...27,882,313 		JBrowse link
G Polq DNA polymerase theta involved_in ISO (PMID:30655289) RGD PMID:30655289 NCBI chr11:63,673,796...63,775,905
Ensembl chr11:63,673,816...63,775,878 		JBrowse link
G Primpol primase and DNA directed polymerase involved_in ISO (PMID:24682820), (PMID:25746449), (PMID:28534480) RGD PMID:24682820 PMID:25746449 PMID:28534480 NCBI chr16:45,681,252...45,715,758
Ensembl chr16:45,681,326...45,715,565 		JBrowse link
G Rev1 REV1, DNA directed polymerase involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:11711549)		 GO_Central
RGD		 PMID:11711549 GO_REF:0000033 NCBI chr 9:40,278,100...40,351,764
Ensembl chr 9:40,278,101...40,351,576 		JBrowse link
G Rev3l REV3 like, DNA directed polymerase zeta catalytic subunit involved_in ISO
IBA		 (PMID:24449906)
GO_REF:0000033		 RGD
GO_Central		 PMID:24449906 GO_REF:0000033 NCBI chr20:43,131,841...43,290,102
Ensembl chr20:43,132,363...43,290,099 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19692
    metabolic process 11448
      organic substance metabolic process 10963
        organic substance biosynthetic process 8108
          macromolecule biosynthetic process 7211
            DNA biosynthetic process 177
              DNA synthesis involved in DNA repair 35
                translesion synthesis 22
                  error-prone translesion synthesis 10
                    negative regulation of error-prone translesion synthesis 0
                    positive regulation of error-prone translesion synthesis 0
                    regulation of error-prone translesion synthesis + 0
Path 2
Term Annotations click to browse term
  biological_process 19692
    metabolic process 11448
      organic substance metabolic process 10963
        organic cyclic compound metabolic process 6032
          nucleobase-containing compound metabolic process 5530
            nucleic acid metabolic process 4955
              DNA metabolic process 962
                DNA repair 545
                  DNA synthesis involved in DNA repair 35
                    translesion synthesis 22
                      error-prone translesion synthesis 10
                        negative regulation of error-prone translesion synthesis 0
                        positive regulation of error-prone translesion synthesis 0
                        regulation of error-prone translesion synthesis + 0
paths to the root