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ONTOLOGY REPORT - ANNOTATIONS

Term:anaphase-promoting complex-dependent catabolic process
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Accession:GO:0031145 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome.
Synonyms:exact_synonym: APC-dependent proteasomal ubiquitin-dependent protein catabolic process;   APC-dependent proteasomal ubiquitin-dependent protein catabolism;   anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein breakdown;   anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;   anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolism;   anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein degradation
 narrow_synonym: cyclin breakdown;   cyclin catabolic process;   cyclin catabolism;   cyclin degradation;   degradation of cyclin;   negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation
 alt_id: GO:0008054


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anaphase-promoting complex-dependent catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anapc1 anaphase promoting complex subunit 1 involved_in IBA
ISO		 GO_REF:0000033
(PMID:29033132)		 GO_Central
RGD		 PMID:29033132 GO_REF:0000033 NCBI chr 3:115,850,117...115,930,259
Ensembl chr 3:115,850,185...115,930,273 		JBrowse link
G Anapc10 anaphase promoting complex subunit 10 involved_in IEA
ISO		 GO_REF:0000002
(PMID:29033132)		 InterPro
RGD		 PMID:29033132 GO_REF:0000002 NCBI chr19:28,152,299...28,205,552
Ensembl chr19:28,152,299...28,205,467 		JBrowse link
G Anapc11 anaphase promoting complex subunit 11 involved_in IEA
ISO		 GO_REF:0000002
(PMID:29033132)		 InterPro
RGD		 PMID:29033132 GO_REF:0000002 NCBI chr10:105,875,209...105,886,307 JBrowse link
G Anapc13 anaphase promoting complex subunit 13 involved_in ISO (PMID:29033132) RGD PMID:29033132 NCBI chr 8:103,205,520...103,213,936
Ensembl chr 8:103,205,520...103,213,936 		JBrowse link
G Anapc15 anaphase promoting complex subunit 15 involved_in ISO
ISS		 (PMID:29033132)
GO_REF:0000024		 RGD
UniProt		 PMID:29033132 GO_REF:0000024 NCBI chr 1:156,238,640...156,266,005
Ensembl chr 1:156,262,841...156,268,145 		JBrowse link
G Anapc16 anaphase promoting complex subunit 16 involved_in ISO (PMID:29033132) RGD PMID:29033132 NCBI chr20:27,927,334...27,941,644
Ensembl chr20:27,927,334...27,941,984 		JBrowse link
G Anapc2 anaphase promoting complex subunit 2 involved_in ISO (PMID:29033132) RGD PMID:29033132 NCBI chr 3:8,086,434...8,098,182
Ensembl chr 3:8,086,462...8,098,178 		JBrowse link
G Anapc4 anaphase promoting complex subunit 4 involved_in IBA
ISO		 GO_REF:0000033
(PMID:29033132)		 GO_Central
RGD		 PMID:29033132 GO_REF:0000033 NCBI chr14:58,125,995...58,159,253
Ensembl chr14:58,125,995...58,157,770 		JBrowse link
G Anapc5 anaphase-promoting complex subunit 5 involved_in IEA
ISS
ISO
IBA		 GO_REF:0000118
GO_REF:0000024
(PMID:29033132)
GO_REF:0000033		 TreeGrafter
UniProt
RGD
GO_Central		 PMID:29033132 GO_REF:0000024 GO_REF:0000033 GO_REF:0000118 NCBI chr12:33,748,709...33,781,709
Ensembl chr12:33,748,735...33,781,781 		JBrowse link
G Anapc7 anaphase promoting complex subunit 7 involved_in ISO (PMID:29033132) RGD PMID:29033132 NCBI chr12:34,131,214...34,160,819
Ensembl chr12:34,133,429...34,160,005 		JBrowse link
G Cdc16 cell division cycle 16 involved_in IBA
ISO		 GO_REF:0000033
(PMID:29033132)		 GO_Central
RGD		 PMID:29033132 GO_REF:0000033 NCBI chr16:75,773,026...75,796,586
Ensembl chr16:75,773,028...75,796,550 		JBrowse link
G Cdc20 cell division cycle 20 involved_in ISO
IBA
IEA		 (PMID:17443180)
GO_REF:0000033
(PMID:18753608)
GO_REF:0000107
GO_REF:0000118		 RGD
GO_Central
Ensembl
TreeGrafter		 PMID:17443180 PMID:18753608 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512 		JBrowse link
G Cdc23 cell division cycle 23 involved_in IBA
ISO		 GO_REF:0000033
(PMID:29033132)		 GO_Central
RGD		 PMID:29033132 GO_REF:0000033 NCBI chr18:26,236,891...26,260,611
Ensembl chr18:26,236,890...26,291,163 		JBrowse link
G Cdc26 cell division cycle 26 involved_in IEA
ISS
ISO		 GO_REF:0000002
GO_REF:0000024
(PMID:29033132)		 InterPro
UniProt
RGD		 PMID:29033132 GO_REF:0000002 GO_REF:0000024 NCBI chr 5:75,844,852...75,859,830 JBrowse link
G Cdc27 cell division cycle 27 involved_in IEA
ISS
ISO
IBA		 GO_REF:0000118
GO_REF:0000024
(PMID:29033132)
GO_REF:0000033		 TreeGrafter
UniProt
RGD
GO_Central		 PMID:29033132 GO_REF:0000024 GO_REF:0000033 GO_REF:0000118 NCBI chr10:89,400,720...89,449,816
Ensembl chr10:89,400,940...89,449,736 		JBrowse link
G Cul3 cullin 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:10500095)
GO_REF:0000107		 RGD
Ensembl		 PMID:10500095 GO_REF:0000107 NCBI chr 9:81,592,641...81,670,428
Ensembl chr 9:81,592,641...81,670,462 		JBrowse link
G Ecrg4 ECRG4 augurin precursor involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000118
(PMID:20404145)
GO_REF:0000033		 TreeGrafter
RGD
GO_Central		 PMID:20404145 GO_REF:0000033 GO_REF:0000118 NCBI chr 9:45,992,954...46,012,605
Ensembl chr 9:45,992,954...46,012,595 		JBrowse link
G ENSRNOG00000066371 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr 5:141,333,595...141,333,940 JBrowse link
G Fbxo31 F-box protein 31 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:19412162)		 UniProt
Ensembl
RGD		 PMID:19412162 GO_REF:0000024 GO_REF:0000107 NCBI chr19:49,624,813...49,656,052
Ensembl chr19:49,627,686...49,656,010 		JBrowse link
G Fzr1 fizzy and cell division cycle 20 related 1 involved_in ISO
IBA		 (PMID:18753608)
GO_REF:0000033
(PMID:14701726), (PMID:18662541), (PMID:21596315)		 RGD
GO_Central		 PMID:14701726 PMID:18662541 PMID:18753608 PMID:21596315 GO_REF:0000033 NCBI chr 7:8,332,029...8,343,953
Ensembl chr 7:8,332,029...8,343,952 		JBrowse link
G LOC103692897 anaphase-promoting complex subunit CDC26 pseudogene involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:73,462,396...73,462,806
Ensembl chr 7:73,462,368...73,462,806
Ensembl chr 7:73,462,368...73,462,806 		JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C involved_in ISO
IBA		 (PMID:19822757), (PMID:9122200)
GO_REF:0000033		 RGD
GO_Central		 PMID:9122200 PMID:19822757 GO_REF:0000033 NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339 		JBrowse link
G Ube2s ubiquitin-conjugating enzyme E2S involved_in ISS
ISO		 GO_REF:0000024
(PMID:19820702), (PMID:19822757)		 UniProt
RGD		 PMID:19820702 PMID:19822757 GO_REF:0000024 NCBI chr 1:69,028,853...69,032,914
Ensembl chr 1:69,028,750...69,032,914 		JBrowse link
positive regulation of anaphase-promoting complex-dependent catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc20 cell division cycle 20 involved_in IBA
IEA		 GO_REF:0000033
GO_REF:0000118		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512 		JBrowse link
G Fzr1 fizzy and cell division cycle 20 related 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:8,332,029...8,343,953
Ensembl chr 7:8,332,029...8,343,952 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    metabolic process 11835
      primary metabolic process 10352
        protein metabolic process 4746
          protein catabolic process 1116
            proteasomal protein catabolic process 590
              proteasome-mediated ubiquitin-dependent protein catabolic process 455
                anaphase-promoting complex-dependent catabolic process 23
                  negative regulation of anaphase-promoting complex-dependent catabolic process 0
                  positive regulation of anaphase-promoting complex-dependent catabolic process 2
                  regulation of anaphase-promoting complex-dependent catabolic process + 2
Path 2
Term Annotations click to browse term
  biological_process 20413
    metabolic process 11835
      organic substance metabolic process 11328
        organic substance catabolic process 2402
          organonitrogen compound catabolic process 1594
            protein catabolic process 1116
              proteolysis involved in protein catabolic process 862
                modification-dependent protein catabolic process 683
                  ubiquitin-dependent protein catabolic process 664
                    proteasome-mediated ubiquitin-dependent protein catabolic process 455
                      anaphase-promoting complex-dependent catabolic process 23
                        negative regulation of anaphase-promoting complex-dependent catabolic process 0
                        positive regulation of anaphase-promoting complex-dependent catabolic process 2
                        regulation of anaphase-promoting complex-dependent catabolic process + 2
paths to the root