serotonin-gated monoatomic cation channel activity - Ontology Report

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Term:	serotonin-gated monoatomic cation channel activity	go back to main search page
Accession:	GO:0022850	browse the term
Definition:	Enables the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts.
Comment:	Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'G protein-coupled serotonin receptor activity ; GO:0004993'.
Synonyms:	exact_synonym:	serotonin-activated cation-selective channel activity; serotonin-gated monoatomic cation-selective channel activity
	narrow_synonym:	5-hydroxytryptamine-gated receptor-channel; serotonin-gated cation channel activity
	broad_synonym:	serotonin-gated cation-selective channel activity
	alt_id:	GO:0005232
	xref:	Reactome:R-HSA-9648983 "HTR3A pentamer:5HT transports Na+,K+,Ca2+"; Reactome:R-HSA-975311 "HTR3 pentamers:5HT transport Na+,K+,Ca2+"

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Genes (2)

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Htr3a

5-hydroxytryptamine receptor 3A

enables

(PMID:7565620), (PMID:9950429)
GO_REF:0000107
GO_REF:0000118
GO_REF:0000033

GO_REF:0000033 GO_REF:0000107 GO_REF:0000118, RGD:625614

NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389

5-hydroxytryptamine receptor 3B

enables

GO_REF:0000107
UniProtKB:P46098 (PMID:7565620), (PMID:9950429)
PMID:10854267
GO_REF:0000118
GO_REF:0000033
(PMID:10854267)

GO_REF:0000033 GO_REF:0000107 GO_REF:0000118, RGD:61635

NCBI chr 8:49,279,291...49,308,444
Ensembl chr 8:49,279,173...49,308,444

Term paths to the root

Path 1
Term	Annotations
molecular_function	21010
molecular transducer activity	2637
signaling receptor activity	2637
transmembrane signaling receptor activity	2427
serotonin receptor activity	3
serotonin-gated monoatomic cation channel activity	2
Path 2
Term	Annotations
molecular_function	21010
transporter activity	1259
transmembrane transporter activity	1163
passive transmembrane transporter activity	519
channel activity	519
gated channel activity	332
ligand-gated channel activity	187
ligand-gated monoatomic ion channel activity	183
extracellular ligand-gated monoatomic ion channel activity	70
transmitter-gated monoatomic ion channel activity	60
serotonin-gated monoatomic cation channel activity	2

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