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ONTOLOGY REPORT - ANNOTATIONS

Term:alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
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Accession:GO:0003828 term browser browse the term
Definition:Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R.
Synonyms:exact_synonym: alpha-N-acetylneuraminide alpha-2,8-sialyltransferase activity
 related_synonym: alpha-2,8-sialyltransferase activity;   cytidine monophosphoacetylneuraminate-ganglioside GM3;   ganglioside GD3 synthase activity;   ganglioside GD3 synthetase sialyltransferase activity
 xref: EC:2.4.3.8;   MetaCyc:2.4.99.8-RXN;   RHEA:19313;   Reactome:R-HSA-9845587 "ST8SIA5 transfers Neu5Ac to gangliosides";   reactome:R-HSA-1022133 "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans";   reactome:R-HSA-4084978 "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues";   reactome:R-HSA-422454 "Polysialylation of NCAM1"


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alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G St8sia1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 enables ISO
IBA		 (PMID:18348864), (PMID:22885356), (PMID:8706663)
GO_REF:0000033		 RGD
GO_Central		 PMID:8706663 PMID:18348864 PMID:22885356 GO_REF:0000033 NCBI chr 4:175,782,989...175,921,338
Ensembl chr 4:175,789,947...175,920,708 		JBrowse link
G St8sia2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 enables ISS
ISO
IBA		 GO_REF:0000024
(PMID:10766765), (PMID:9774483)
GO_REF:0000033
(MGI:74245|PMID:7782326), (PMID:7875291)		 UniProt
RGD
GO_Central		 PMID:7782326 PMID:7875291 PMID:9774483 PMID:10766765 GO_REF:0000024 GO_REF:0000033 MGI:74245 NCBI chr 1:127,762,573...127,838,017
Ensembl chr 1:127,762,573...127,838,091 		JBrowse link
G St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 enables ISO
IBA		 (PMID:10766765), (PMID:26192331), (PMID:9826427)
GO_REF:0000033
(PMID:7782326)		 RGD
GO_Central		 PMID:7782326 PMID:9826427 PMID:10766765 PMID:26192331 GO_REF:0000033 NCBI chr18:57,754,349...57,760,839
Ensembl chr18:57,754,347...57,760,839 		JBrowse link
G St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 enables ISO
IBA		 (PMID:10766765), (PMID:9774483)
GO_REF:0000033
(PMID:8690732)		 RGD
GO_Central		 PMID:8690732 PMID:9774483 PMID:10766765 GO_REF:0000033 NCBI chr 9:95,990,131...96,084,661
Ensembl chr 9:95,993,503...96,084,653 		JBrowse link
G St8sia5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 enables IBA
ISO		 GO_REF:0000033
(PMID:8910600)		 GO_Central
RGD		 PMID:8910600 GO_REF:0000033 NCBI chr18:70,736,395...70,802,537
Ensembl chr18:70,736,602...70,797,789 		JBrowse link
G St8sia6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:76,740,755...76,884,178
Ensembl chr17:76,745,224...76,884,299 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  molecular_function 20487
    catalytic activity 6037
      transferase activity 2398
        glycosyltransferase activity 284
          sialyltransferase activity 21
            alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity 6
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