St8sia2 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: St8sia2 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2) Rattus norvegicus
Analyze
Symbol: St8sia2
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
RGD ID: 621843
Description: Enables sialyltransferase activity. Involved in several processes, including neuron projection extension; positive regulation of synapse assembly; and response to cocaine. Located in perinuclear region of cytoplasm. Orthologous to human ST8SIA2 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2); INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-2,8-sialyltransferase 8B; sialyltransferase 8 (alpha-2 8-sialytransferase) B; sialyltransferase 8 (alpha-2, 8-sialyltransferase) B; sialyltransferase 8 (alpha-2, 8-sialytransferase) B; sialyltransferase 8B; sialyltransferase St8Sia II; sialyltransferase X; sialytransferase St8Sia II; SIAT8-B; Siat8b; ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 2; ST8Sia II; ST8SiaII; STX
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   WKY.SHRSP-(D1Rat25-St8sia2)/Izm  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81137,172,354 - 137,247,796 (-)NCBIGRCr8
mRatBN7.21127,762,573 - 127,838,017 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1127,762,573 - 127,838,091 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1135,709,155 - 135,780,162 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01142,879,281 - 142,950,280 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01135,752,974 - 135,824,111 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01135,336,374 - 135,406,699 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1135,336,374 - 135,406,700 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01136,353,283 - 136,423,629 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41129,158,717 - 129,191,810 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11129,237,058 - 129,270,153 (+)NCBI
Celera1119,890,482 - 119,961,512 (-)NCBICelera
Cytogenetic Map1q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Differential regulation of polysialyltransferase expression during hippocampus development: Implications for neuronal survival. Brocco M, etal., J Neurosci Res. 2003 Dec 1;74(5):744-53. doi: 10.1002/jnr.10781.
2. Interfering polysialyltransferase ST8SiaII/STX mRNA inhibits neurite growth during early hippocampal development. Brocco MA and Frasch AC, FEBS Lett. 2006 Aug 21;580(19):4723-6. doi: 10.1016/j.febslet.2006.07.058. Epub 2006 Jul 26.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Biosynthesis and expression of polysialic acid on the neural cell adhesion molecule is predominantly directed by ST8Sia II/STX during in vitro neuronal differentiation. Kojima N, etal., J Biol Chem. 1996 Sep 6;271(36):22058-62. doi: 10.1074/jbc.271.36.22058.
5. Polymerase chain reaction cloning of a developmentally regulated member of the sialyltransferase gene family. Livingston BD and Paulson JC, J Biol Chem 1993 Jun 5;268(16):11504-7.
6. Cocaine enhances ST8SiaII mRNA expression and neural cell adhesion molecule polysialylation in the rat medial prefrontal cortex. Maćkowiak M, etal., Neuroscience. 2011 Jul 14;186:21-31. doi: 10.1016/j.neuroscience.2011.04.030. Epub 2011 Apr 19.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7875291   PMID:10766765   PMID:23303939   PMID:24753009   PMID:26844880  


Genomics

Comparative Map Data
St8sia2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81137,172,354 - 137,247,796 (-)NCBIGRCr8
mRatBN7.21127,762,573 - 127,838,017 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1127,762,573 - 127,838,091 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1135,709,155 - 135,780,162 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01142,879,281 - 142,950,280 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01135,752,974 - 135,824,111 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01135,336,374 - 135,406,699 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1135,336,374 - 135,406,700 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01136,353,283 - 136,423,629 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41129,158,717 - 129,191,810 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11129,237,058 - 129,270,153 (+)NCBI
Celera1119,890,482 - 119,961,512 (-)NCBICelera
Cytogenetic Map1q31NCBI
ST8SIA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381592,393,881 - 92,468,728 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1592,393,881 - 92,468,728 (+)EnsemblGRCh38hg38GRCh38
GRCh371592,937,111 - 93,011,958 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361590,738,144 - 90,812,962 (+)NCBINCBI36Build 36hg18NCBI36
Build 341590,738,143 - 90,812,960NCBI
Celera1569,348,987 - 69,423,804 (+)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1569,073,963 - 69,148,782 (+)NCBIHuRef
CHM1_11592,778,223 - 92,853,016 (+)NCBICHM1_1
T2T-CHM13v2.01590,156,330 - 90,231,154 (+)NCBIT2T-CHM13v2.0
St8sia2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39773,588,867 - 73,663,408 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl773,588,867 - 73,663,438 (-)EnsemblGRCm39 Ensembl
GRCm38773,939,119 - 74,013,727 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl773,939,119 - 74,013,690 (-)EnsemblGRCm38mm10GRCm38
MGSCv37781,084,005 - 81,158,568 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36773,812,634 - 73,887,174 (-)NCBIMGSCv36mm8
Celera771,386,077 - 71,460,843 (-)NCBICelera
Cytogenetic Map7D1NCBI
cM Map742.27NCBI
St8sia2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541620,697,651 - 20,767,112 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541620,697,651 - 20,763,975 (+)NCBIChiLan1.0ChiLan1.0
ST8SIA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21681,944,128 - 82,019,429 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11585,644,544 - 85,725,911 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01571,082,491 - 71,158,038 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11590,279,509 - 90,354,173 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1590,279,509 - 90,354,173 (+)Ensemblpanpan1.1panPan2
ST8SIA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1347,588,804 - 47,654,853 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl347,588,797 - 47,655,593 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha350,295,210 - 50,356,703 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0348,001,090 - 48,073,258 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl348,001,047 - 48,073,994 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1347,521,309 - 47,582,785 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0347,753,561 - 47,815,049 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0348,085,662 - 48,147,171 (-)NCBIUU_Cfam_GSD_1.0
St8sia2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640135,991,306 - 136,055,640 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648310,278,838 - 10,313,905 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648310,278,843 - 10,343,177 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ST8SIA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl786,446,149 - 86,514,393 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1786,450,302 - 86,514,232 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2792,389,280 - 92,455,864 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ST8SIA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12910,966,738 - 11,039,014 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2911,000,989 - 11,041,634 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605935,633,373 - 35,710,140 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
St8sia2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476811,234,281 - 11,302,237 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476811,238,134 - 11,302,280 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in St8sia2
486 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:146
Count of miRNA genes:116
Interacting mature miRNAs:122
Transcripts:ENSRNOT00000016427
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)199267916144267916Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)199267916144267916Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1102168504147168504Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1102268556147268556Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1102813953151162766Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1103111621148111621Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847151047847Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
2325726Eae30Experimental allergic encephalomyelitis QTL 30nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1123053310128593844Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123479780142990467Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat

Markers in Region
STS-L29556  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21127,766,718 - 127,766,950 (+)MAPPERmRatBN7.2
Rnor_6.01135,336,424 - 135,336,655NCBIRnor6.0
Rnor_5.01136,353,333 - 136,353,564UniSTSRnor5.0
RGSC_v3.41129,191,529 - 129,191,760UniSTSRGSC3.4
Celera1119,890,532 - 119,890,763UniSTS
Cytogenetic Map1q31UniSTS
D1Bda26  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21127,766,672 - 127,766,934 (+)MAPPERmRatBN7.2
Rnor_6.01135,336,378 - 135,336,639NCBIRnor6.0
Rnor_5.01136,353,287 - 136,353,548UniSTSRnor5.0
RGSC_v3.41129,191,545 - 129,191,806UniSTSRGSC3.4
Celera1119,890,486 - 119,890,747UniSTS
Cytogenetic Map1q31UniSTS
AU047261  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21127,835,974 - 127,836,118 (+)MAPPERmRatBN7.2
Rnor_6.01135,404,863 - 135,405,006NCBIRnor6.0
Rnor_5.01136,421,850 - 136,421,993UniSTSRnor5.0
RGSC_v3.41129,266,325 - 129,266,468UniSTSRGSC3.4
Celera1119,959,752 - 119,959,887UniSTS
Cytogenetic Map1q31UniSTS
AU047260  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21127,835,940 - 127,836,217 (+)MAPPERmRatBN7.2
Rnor_6.01135,404,829 - 135,405,105NCBIRnor6.0
Rnor_5.01136,421,816 - 136,422,092UniSTSRnor5.0
RGSC_v3.41129,266,291 - 129,266,567UniSTSRGSC3.4
Celera1119,959,718 - 119,959,986UniSTS
Cytogenetic Map1q31UniSTS


Related Rat Strains
The following Strains have been annotated to St8sia2
WKY.SHRSP-(D1Rat25-St8sia2)/Izm    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 51 6 30 4
Low 28 14 6 8 6 6 6 23 15 11 7 6
Below cutoff 2 12 25 18 8 18 2 5 3 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016427
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1135,336,374 - 135,406,642 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076348
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1135,336,374 - 135,406,642 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079929
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1135,336,374 - 135,406,700 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113519   ⟹   ENSRNOP00000092932
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1127,762,573 - 127,838,091 (-)Ensembl
RefSeq Acc Id: NM_057156   ⟹   NP_476497
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81137,172,354 - 137,247,753 (-)NCBI
mRatBN7.21127,762,573 - 127,837,973 (-)NCBI
Rnor_6.01135,336,374 - 135,406,699 (-)NCBI
Rnor_5.01136,353,283 - 136,423,629 (-)NCBI
RGSC_v3.41129,158,717 - 129,191,810 (+)RGD
Celera1119,890,482 - 119,961,512 (-)RGD
Sequence:
RefSeq Acc Id: XM_063268334   ⟹   XP_063124404
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81137,176,744 - 137,247,796 (-)NCBI
Protein Sequences
Protein RefSeqs NP_476497 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124404 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42147 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000092932
  ENSRNOP00000092932.1
  ENSRNOP00065039350
GenBank Protein Q07977 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_476497   ⟸   NM_057156
- Peptide Label: precursor
- UniProtKB: Q64688 (UniProtKB/Swiss-Prot),   Q07977 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000092932   ⟸   ENSRNOT00000113519
RefSeq Acc Id: XP_063124404   ⟸   XM_063268334
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q07977-F1-model_v2 AlphaFold Q07977 1-375 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621843 AgrOrtholog
BioCyc Gene G2FUF-58874 BioCyc
Ensembl Genes ENSRNOG00000012031 Ensembl
  ENSRNOG00000065528 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00065027807 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000113519 ENTREZGENE
  ENSRNOT00000113519.1 UniProtKB/Swiss-Prot
  ENSRNOT00065047942 UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.1480.20 UniProtKB/Swiss-Prot
InterPro Glyco_trans_29 UniProtKB/Swiss-Prot
  GT29-like_sf UniProtKB/Swiss-Prot
  Sialyl_trans UniProtKB/Swiss-Prot
KEGG Report rno:117523 UniProtKB/Swiss-Prot
NCBI Gene 117523 ENTREZGENE
PANTHER ALPHA-2,8-SIALYLTRANSFERASE UniProtKB/Swiss-Prot
  ALPHA-2,8-SIALYLTRANSFERASE 8B UniProtKB/Swiss-Prot
Pfam Glyco_transf_29 UniProtKB/Swiss-Prot
PhenoGen St8sia2 PhenoGen
PIRSF Sialyl_trans UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012031 RatGTEx
  ENSRNOG00000065528 RatGTEx
  ENSRNOG00065027807 RatGTEx
UniProt Q07977 ENTREZGENE
  Q64688 ENTREZGENE
  SIA8B_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q64688 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-05 St8sia2  ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2  St8sia2  ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-15 St8sia2  ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 2  St8sia2  ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 St8sia2  ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2  Siat8b  sialyltransferase 8 (alpha-2, 8-sialyltransferase) B  Symbol and Name updated 1299863 APPROVED
2005-01-20 Siat8b  sialyltransferase 8 (alpha-2, 8-sialyltransferase) B      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Siat8b        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed specifically in newborn brain 729711