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ONTOLOGY REPORT - ANNOTATIONS

Term:planar cell polarity pathway involved in neural tube closure
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Accession:GO:0090179 term browser browse the term
Definition:The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors that modulates the establishment of planar polarity contributing to neural tube closure.


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planar cell polarity pathway involved in neural tube closure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CELSR1 cadherin EGF LAG seven-pass G-type receptor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20704721) Ensembl
MGI		 PMID:20704721 GO_REF:0000107 NCBI chr10:19,704,104...19,836,886
Ensembl chr10:19,707,804...19,837,481 		JBrowse link
G DVL1 dishevelled segment polarity protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16571627) Ensembl
MGI
TreeGrafter		 PMID:16571627 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:56,507,803...56,519,382
Ensembl chr 5:56,507,739...56,519,491 		JBrowse link
G DVL2 dishevelled segment polarity protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16571627) Ensembl
MGI
TreeGrafter		 PMID:16571627 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:32,194,326...32,201,922
Ensembl chr 5:32,194,313...32,201,857 		JBrowse link
G DVL3 dishevelled segment polarity protein 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19008950) TreeGrafter
MGI		 PMID:19008950 GO_REF:0000118 NCBI chr34:17,053,534...17,069,965
Ensembl chr34:17,053,343...17,068,389 		JBrowse link
G FZD1 frizzled class receptor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20940229) Ensembl
MGI		 PMID:20940229 GO_REF:0000107 NCBI chr14:17,046,911...17,050,515
Ensembl chr14:17,047,382...17,049,337 		JBrowse link
G FZD2 frizzled class receptor 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20940229) Ensembl
MGI		 PMID:20940229 GO_REF:0000107 NCBI chr 9:18,888,711...18,890,549
Ensembl chr 9:18,888,696...18,890,525 		JBrowse link
G GRHL3 grainyhead like transcription factor 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20643356) Ensembl
MGI		 PMID:20643356 GO_REF:0000107 NCBI chr 2:75,290,594...75,324,593
Ensembl chr 2:75,290,596...75,324,496 		JBrowse link
G PTK7 protein tyrosine kinase 7 (inactive) involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20704721) Ensembl
MGI		 PMID:20704721 GO_REF:0000107 NCBI chr12:11,593,017...11,657,149
Ensembl chr12:11,593,043...11,656,320 		JBrowse link
G SFRP1 secreted frizzled related protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18257070) Ensembl
MGI		 PMID:18257070 GO_REF:0000107 NCBI chr16:24,262,451...24,306,162
Ensembl chr16:24,261,946...24,302,964 		JBrowse link
G SFRP2 secreted frizzled related protein 2 acts_upstream_of_or_within ISO (PMID:18257070) MGI PMID:18257070 NCBI chr15:51,541,197...51,548,765
Ensembl chr15:51,540,500...51,548,765 		JBrowse link
G SFRP5 secreted frizzled related protein 5 acts_upstream_of_or_within ISO (PMID:18257070) MGI PMID:18257070 NCBI chr28:10,994,180...10,999,552
Ensembl chr28:10,993,930...10,999,564 		JBrowse link
G VANGL2 VANGL planar cell polarity protein 2 acts_upstream_of_or_within ISO (PMID:16571627)
(PMID:18257070)
(PMID:20940229)
(PMID:20704721)
(PMID:20643356)
(PMID:19008950)		 MGI PMID:16571627 PMID:18257070 PMID:19008950 PMID:20643356 PMID:20704721 More... NCBI chr38:21,822,873...21,824,537 JBrowse link
G WNT5A Wnt family member 5A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19056682) Ensembl
MGI		 PMID:19056682 GO_REF:0000107 NCBI chr20:34,756,430...34,790,937
Ensembl chr20:34,769,930...34,786,673 		JBrowse link
negative regulation of planar cell polarity pathway involved in neural tube closure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LRP6 LDL receptor related protein 6 acts_upstream_of_or_within ISO (PMID:19056682) MGI PMID:19056682 NCBI chr27:34,003,334...34,166,334
Ensembl chr27:34,003,539...34,161,437 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17925
    developmental process 6840
      anatomical structure formation involved in morphogenesis 1369
        tube formation 186
          tube closure 117
            neural tube closure 116
              planar cell polarity pathway involved in neural tube closure 14
                negative regulation of planar cell polarity pathway involved in neural tube closure 1
                regulation of planar cell polarity pathway involved in neural tube closure + 1
Path 2
Term Annotations click to browse term
  biological_process 17925
    developmental process 6840
      anatomical structure development 6424
        multicellular organism development 5184
          tube development 1328
            tube morphogenesis 1030
              tube formation 186
                epithelial tube formation 173
                  embryonic epithelial tube formation 161
                    neural tube formation 136
                      primary neural tube formation 123
                        neural tube closure 116
                          establishment of planar polarity involved in neural tube closure 16
                            regulation of establishment of planar polarity involved in neural tube closure 15
                              planar cell polarity pathway involved in neural tube closure 14
                                negative regulation of planar cell polarity pathway involved in neural tube closure 1
                                regulation of planar cell polarity pathway involved in neural tube closure + 1
paths to the root