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ONTOLOGY REPORT - ANNOTATIONS

Term:voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
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Accession:GO:0086008 term browser browse the term
Definition:Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


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voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 contributes_to ISO (PMID:10400998) RGD PMID:10400998 NCBI chr11:31,580,951...31,594,116
Ensembl chr11:31,580,742...31,593,901 		JBrowse link
G Kcne5 potassium voltage-gated channel subfamily E regulatory subunit 5 contributes_to ISO (PMID:21493962) RGD PMID:21493962 NCBI chr  X:105,930,398...105,931,013
Ensembl chr  X:105,930,398...105,931,013 		JBrowse link
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 enables ISO (PMID:11371347) RGD PMID:11371347 NCBI chr10:96,060,834...96,071,397
Ensembl chr10:96,060,821...96,071,445 		JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 enables ISO (PMID:12522251) RGD PMID:12522251 NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669 		JBrowse link
voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcna5 potassium voltage-gated channel subfamily A member 5 enables ISO (PMID:19343045), (PMID:23264583) RGD PMID:19343045 PMID:23264583 NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697 		JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 enables ISO
IEA		 (PMID:20560207)
GO_REF:0000107		 RGD
Ensembl		 PMID:20560207 GO_REF:0000107 NCBI chr 8:30,724,923...30,753,083
Ensembl chr 8:30,724,925...30,753,518 		JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 enables ISO
IBA
IEA		 (PMID:12522251), (PMID:25786344)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:12522251 PMID:25786344 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669 		JBrowse link
voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcna5 potassium voltage-gated channel subfamily A member 5 enables ISO (PMID:23264583) RGD PMID:23264583 NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697 		JBrowse link
voltage-gated potassium channel activity involved in SA node cell action potential repolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcna5 potassium voltage-gated channel subfamily A member 5 enables ISO (PMID:19343045), (PMID:23264583) RGD PMID:19343045 PMID:23264583 NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697 		JBrowse link
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnd3 potassium voltage-gated channel subfamily D member 3 contributes_to
enables		 ISO
IEA		 (PMID:21349352)
GO_REF:0000107		 RGD
Ensembl		 PMID:21349352 GO_REF:0000107 NCBI chr 2:192,937,950...193,155,345
Ensembl chr 2:192,937,950...193,155,345 		JBrowse link
G Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 contributes_to ISO (PMID:9354802) RGD PMID:9354802 NCBI chr11:31,580,951...31,594,116
Ensembl chr11:31,580,742...31,593,901 		JBrowse link
G Kcne2 potassium voltage-gated channel subfamily E regulatory subunit 2 enables
contributes_to		 ISO
IBA		 (PMID:10219239)
GO_REF:0000033		 RGD
GO_Central		 PMID:10219239 GO_REF:0000033 NCBI chr11:31,517,176...31,530,026
Ensembl chr11:31,295,614...31,530,043 		JBrowse link
G Kcne3 potassium voltage-gated channel subfamily E regulatory subunit 3 contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:154,523,903...154,530,865
Ensembl chr 1:154,523,830...154,532,020 		JBrowse link
G Kcne4 potassium voltage-gated channel subfamily E regulatory subunit 4 contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:80,243,429...80,251,533
Ensembl chr 9:80,247,379...80,250,979 		JBrowse link
G Kcne5 potassium voltage-gated channel subfamily E regulatory subunit 5 contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:105,930,398...105,931,013
Ensembl chr  X:105,930,398...105,931,013 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 enables ISO (PMID:21536673) RGD PMID:21536673 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 enables ISO (PMID:20558321) RGD PMID:20558321 NCBI chr 4:175,508,908...175,515,829
Ensembl chr 4:175,508,912...175,515,603 		JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 enables IEA
ISO
IBA		 GO_REF:0000107
(PMID:8528244)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:8528244 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669 		JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 enables ISO MGI:2451362 (PMID:27932425) RGD PMID:27932425 NCBI chr 8:45,425,629...45,437,765
Ensembl chr 8:45,425,629...45,437,765 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20483
    transporter activity 1237
      transmembrane transporter activity 1143
        monoatomic ion transmembrane transporter activity 759
          monoatomic ion channel activity 448
            monoatomic cation channel activity 337
              potassium channel activity 128
                voltage-gated potassium channel activity 102
                  voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 13
                    voltage-gated potassium channel activity involved in AV node cell action potential repolarization 0
                    voltage-gated potassium channel activity involved in Purkinje myocyte action potential repolarization 0
                    voltage-gated potassium channel activity involved in SA node cell action potential repolarization 1
                    voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization 3
                    voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization 1
                    voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 10
Path 2
Term Annotations click to browse term
  molecular_function 20483
    transporter activity 1237
      transmembrane transporter activity 1143
        passive transmembrane transporter activity 507
          channel activity 507
            gated channel activity 331
              voltage-gated channel activity 187
                voltage-gated monoatomic ion channel activity 184
                  voltage-gated monoatomic cation channel activity 151
                    voltage-gated potassium channel activity 102
                      voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 13
                        voltage-gated potassium channel activity involved in AV node cell action potential repolarization 0
                        voltage-gated potassium channel activity involved in Purkinje myocyte action potential repolarization 0
                        voltage-gated potassium channel activity involved in SA node cell action potential repolarization 1
                        voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization 3
                        voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization 1
                        voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 10
paths to the root