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ONTOLOGY REPORT - ANNOTATIONS

Term:pyroptotic inflammatory response
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Accession:GO:0070269 term browser browse the term
Definition:A gasdermin-dependent inflammatory response that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18. Gasdermins are activated by caspase-1 or caspase-4/11, or by certain granzymes. In some, but not all cells, it can lead to pyroptotic programmed cell death.
Synonyms:broad_synonym: pyroptosis


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pyroptotic inflammatory response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIM2 absent in melanoma 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:134,413,232...134,540,344
Ensembl chr 1:138,210,946...138,221,753 		JBrowse link
G APIP APAF1 interacting protein involved_in ISO (PMID:24367089) UniProt PMID:24367089 NCBI chr11:34,855,437...34,889,486
Ensembl chr11:34,730,671...34,764,732 		JBrowse link
G CARD8 caspase recruitment domain family member 8 involved_in ISO (PMID:32840892), (PMID:33542150), (PMID:34019797) UniProt PMID:32840892 PMID:33542150 PMID:34019797 NCBI chr19:45,204,735...45,256,481
Ensembl chr19:53,798,967...53,850,328 		JBrowse link
G CASP1 caspase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22002608) Ensembl
MGI		 PMID:22002608 GO_REF:0000107 NCBI chr11:99,965,964...99,975,640
Ensembl chr11:103,448,497...103,458,149
Ensembl chr11:103,448,497...103,458,149 		JBrowse link
G CASP3 caspase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:176,793,190...176,815,023
Ensembl chr 4:189,018,422...189,040,185 		JBrowse link
G CASP4 caspase 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22002608) Ensembl
MGI		 PMID:22002608 GO_REF:0000107 NCBI chr11:99,883,353...99,909,185
Ensembl chr11:103,366,138...103,391,824 		JBrowse link
G CASP6 caspase 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:102,186,215...102,201,992
Ensembl chr 4:112,753,988...112,768,836 		JBrowse link
G CASP8 caspase 8 involved_in ISO (MGI:6401035|PMID:31748744)
(MGI:6270017|PMID:30361383)		 UniProt PMID:30361383 PMID:31748744 MGI:6270017 MGI:6401035 NCBI chr2B:88,490,611...88,542,132
Ensembl chr2B:206,669,544...206,696,468 		JBrowse link
G DHX9 DExH-box helicase 9 involved_in ISO (MGI:5908739|PMID:28636595) UniProt PMID:28636595 MGI:5908739 NCBI chr 1:158,355,472...158,404,178
Ensembl chr 1:162,006,822...162,055,833 		JBrowse link
G DPP9 dipeptidyl peptidase 9 acts_upstream_of_negative_effect
involved_in		 ISO
IEA		 (PMID:33731929), (PMID:34019797) UniProt
Ensembl		 PMID:33731929 PMID:34019797 GO_REF:0000107 NCBI chr19:3,693,460...3,743,594
Ensembl chr19:4,644,371...4,693,789 		JBrowse link
G GSDMA gasdermin A involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr17:17,311,932...17,324,004
Ensembl chr17:17,531,767...17,543,413 		JBrowse link
G GSDMB gasdermin B NOT|involved_in ISO
IEA		 (PMID:36899106), (PMID:36991122), (PMID:36991125) UniProt
TreeGrafter		 PMID:36899106 PMID:36991122 PMID:36991125 GO_REF:0000118 NCBI chr17:17,370,351...17,384,639
Ensembl chr17:17,590,018...17,604,177 		JBrowse link
G GSDMC gasdermin C involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 8:126,384,575...126,423,505
Ensembl chr 8:129,118,445...129,147,808 		JBrowse link
G GSDMD gasdermin D involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:140,311,042...140,316,084
Ensembl chr 8:143,326,319...143,331,455 		JBrowse link
G GSDME gasdermin E involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:25,373,485...25,433,001
Ensembl chr 7:24,977,838...25,039,525 		JBrowse link
G GZMA granzyme A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:58,919,129...58,926,620
Ensembl chr 5:60,540,988...60,548,506 		JBrowse link
G GZMB granzyme B involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:5,399,888...5,403,200
Ensembl chr14:23,523,619...23,526,931 		JBrowse link
G IFI27 interferon alpha inducible protein 27 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:74,742,775...74,748,820
Ensembl chr14:94,046,694...94,082,022 		JBrowse link
G MAP3K20 mitogen-activated protein kinase kinase kinase 20 involved_in
acts_upstream_of_positive_effect		 IEA
ISO		 (PMID:35857590) Ensembl
UniProt		 PMID:35857590 GO_REF:0000107 NCBI chr2B:60,362,635...60,555,445
Ensembl chr2B:177,818,344...178,010,556 		JBrowse link
G NAIP NLR family apoptosis inhibitory protein involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 5:44,345,623...44,401,358
Ensembl chr 5:45,920,125...45,973,937 		JBrowse link
G NINJ1 ninjurin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:64,245,086...64,258,614
Ensembl chr 9:92,311,502...92,324,030 		JBrowse link
G NLRC4 NLR family CARD domain containing 4 involved_in ISO (MGI:3662989|PMID:16648853), (MGI:3662990|PMID:16648852), (MGI:5289703|PMID:21874021), (MGI:5428366|PMID:22484733), (MGI:5444805|PMID:22885697) UniProt PMID:16648852 PMID:16648853 PMID:21874021 PMID:22484733 PMID:22885697 MGI:3662989 MGI:3662990 MGI:5289703 MGI:5428366 MGI:5444805 NCBI chr2A:32,241,782...32,284,041
Ensembl chr2A:32,954,185...32,996,465 		JBrowse link
G NLRP1 NLR family pyrin domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:5,562,129...5,667,765
Ensembl chr17:5,542,007...5,623,091 		JBrowse link
G NLRP6 NLR family pyrin domain containing 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:30248149) Ensembl
MGI		 PMID:30248149 GO_REF:0000107 NCBI chr11:274,904...281,590
Ensembl chr11:319,082...325,888 		JBrowse link
G NLRP9 NLR family pyrin domain containing 9 involved_in ISO (MGI:5908739|PMID:28636595) UniProt PMID:28636595 MGI:5908739 NCBI chr19:52,755,932...52,787,678
Ensembl chr19:61,440,710...61,473,249 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 acts_upstream_of_or_within_negative_effect
involved_in		 ISO
IEA		 (MGI:6391726|PMID:29887864) ARUK-UCL
Ensembl		 PMID:29887864 GO_REF:0000107 MGI:6391726 NCBI chr 6:40,735,483...40,740,208
Ensembl chr 6:42,043,900...42,048,578 		JBrowse link
G TRIM21 tripartite motif containing 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:4,588,083...4,596,942
Ensembl chr11:4,254,152...4,262,981 		JBrowse link
G ZBP1 Z-DNA binding protein 1 involved_in ISO (MGI:6442612|PMID:27917412), (MGI:6453154|PMID:32350114), (MGI:6490907|PMID:33109609) UniProt PMID:27917412 PMID:32350114 PMID:33109609 MGI:6442612 MGI:6453154 MGI:6490907 NCBI chr20:53,944,224...53,961,362
Ensembl chr20:55,222,405...55,239,130 		JBrowse link
G ZEB2 zinc finger E-box binding homeobox 2 ISO RGD PMID:34852714 RGD:155882542 NCBI chr2B:15,325,094...15,460,908
Ensembl chr2B:148,460,904...148,596,500 		JBrowse link
cytotoxic T cell pyroptotic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GSDMB gasdermin B involved_in ISO (PMID:28154144), (PMID:32299851), (PMID:34022140), (PMID:36599845), (PMID:36991122), (PMID:36991125) UniProt PMID:28154144 PMID:32299851 PMID:34022140 PMID:36599845 PMID:36991122 More... NCBI chr17:17,370,351...17,384,639
Ensembl chr17:17,590,018...17,604,177 		JBrowse link
G GZMA granzyme A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:58,919,129...58,926,620
Ensembl chr 5:60,540,988...60,548,506 		JBrowse link
positive regulation of pyroptotic inflammatory response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:176,793,190...176,815,023
Ensembl chr 4:189,018,422...189,040,185 		JBrowse link
G GBP1 guanylate binding protein 1 involved_in ISO (MGI:5565107|PMID:24715728)
(PMID:31268602)		 UniProt PMID:24715728 PMID:31268602 MGI:5565107 NCBI chr 1:91,763,835...91,776,843
Ensembl chr 1:90,467,260...90,528,491 		JBrowse link
G GBP2 guanylate binding protein 2 involved_in ISO (MGI:5565107|PMID:24715728)
(MGI:5774627|PMID:25774716), (MGI:5774628|PMID:25774715), (MGI:7432484|PMID:30062052)		 UniProt PMID:24715728 PMID:25774715 PMID:25774716 PMID:30062052 MGI:5565107 MGI:5774627 MGI:5774628 MGI:7432484 NCBI chr 1:91,816,602...91,836,594
Ensembl chr 1:90,569,151...90,588,158 		JBrowse link
G GBP4 guanylate binding protein 4 involved_in ISO (MGI:5565107|PMID:24715728) UniProt PMID:24715728 MGI:5565107 NCBI chr 1:91,892,368...91,910,048
Ensembl chr 1:90,590,242...90,660,565 		JBrowse link
G GBP5 guanylate binding protein 5 involved_in ISO (MGI:5565107|PMID:24715728)
(MGI:5774627|PMID:25774716), (MGI:5774628|PMID:25774715), (MGI:7432483|PMID:30589883)		 UniProt PMID:24715728 PMID:25774715 PMID:25774716 PMID:30589883 MGI:5565107 MGI:5774627 MGI:5774628 MGI:7432483 NCBI chr 1:91,969,699...92,006,127
Ensembl chr 1:90,720,927...90,729,757 		JBrowse link
G NLRP1 NLR family pyrin domain containing 1 ISO RGD PMID:24626226 RGD:38549348 NCBI chr17:5,562,129...5,667,765
Ensembl chr17:5,542,007...5,623,091 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16447
    response to stimulus 8503
      response to stress 3913
        defense response 1658
          inflammatory response 754
            pyroptotic inflammatory response 33
              negative regulation of pyroptotic inflammatory response 0
              positive regulation of pyroptotic inflammatory response 6
              pyroptotic cell death + 2
paths to the root