GZMB (granzyme B) - Rat Genome Database

Name: GZMB
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: GZMB (granzyme B) Pan paniscus

Analyze

Symbol:

GZMB

Name:

granzyme B

RGD ID:

11765975

Description:

ENCODES a protein that exhibits serine-type endopeptidase activity (ortholog); INVOLVED IN defense response to bacterium (ortholog); granzyme-mediated programmed cell death signaling pathway (ortholog); neuron apoptotic process (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); autistic disorder (ortholog); brain infarction (ortholog); FOUND IN cytoplasm (ortholog); early endosome (ortholog); extracellular space (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	25,978,516 - 25,981,806 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	25,195,008 - 25,198,304 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	5,399,888 - 5,403,200 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	23,523,619 - 23,526,931 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	23,523,619 - 23,526,931 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Lung Injury (ISO)

autistic disorder (ISO)

brain infarction (ISO)

Brain-Lung-Thyroid Syndrome (ISO)

Breast Neoplasms (ISO)

bronchiolitis obliterans (ISO)

chronic obstructive pulmonary disease (ISO)

COVID-19 (ISO)

drug allergy (ISO)

genetic disease (ISO)

hepatitis (ISO)

lysinuric protein intolerance (ISO)

Specific Granule Deficiency (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

defense response to bacterium (ISO)

granzyme-mediated programmed cell death signaling pathway (IEA,ISO)

natural killer cell mediated cytotoxicity (IEA)

negative regulation of translation (IEA)

neuron apoptotic process (ISO)

positive regulation of necroptotic process (ISO)

protein maturation (IEA)

proteolysis (IEA)

proteolysis involved in protein catabolic process (IEA)

pyroptosis (IEA)

T cell mediated cytotoxicity (ISO)

Cellular Component

cytolytic granule (IEA)

cytoplasm (IEA,ISO)

early endosome (ISO)

extracellular space (ISO)

intracellular membrane-bounded organelle (IEA)

Molecular Function

hydrolase activity (IEA)

peptidase activity (IEA)

protein binding (ISO)

serine-type endopeptidase activity (IEA,ISO)

serine-type peptidase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

interleukin-12 signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

GZMB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	25,978,516 - 25,981,806 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	25,195,008 - 25,198,304 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	5,399,888 - 5,403,200 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	23,523,619 - 23,526,931 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	23,523,619 - 23,526,931 (-)	Ensembl	panpan1.1		panPan2

GZMB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	24,630,954 - 24,634,190 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	24,630,954 - 24,634,267 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	25,100,160 - 25,103,396 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	24,170,000 - 24,173,272 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	24,170,003 - 24,173,272	NCBI
Celera	14	4,964,951 - 4,968,224 (-)	NCBI		Celera
Cytogenetic Map	14	q12	NCBI
HuRef	14	5,214,872 - 5,218,144 (-)	NCBI		HuRef
CHM1_1	14	25,099,053 - 25,102,325 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	18,829,837 - 18,833,074 (-)	NCBI		T2T-CHM13v2.0

Gzmb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	56,496,293 - 56,499,791 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	56,496,295 - 56,499,717 (-)	Ensembl		GRCm39 Ensembl
GRCm38	14	56,258,836 - 56,262,334 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	56,258,838 - 56,262,260 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	56,877,693 - 56,881,097 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	55,212,927 - 55,216,331 (-)	NCBI		MGSCv36	mm8
Celera	14	54,055,471 - 54,058,875 (-)	NCBI		Celera
Cytogenetic Map	14	C3	NCBI
cM Map	14	28.19	NCBI

Gzmb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	34,459,007 - 34,462,469 (-)	NCBI		GRCr8
mRatBN7.2	15	30,343,352 - 30,346,814 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	30,173,603 - 30,346,814 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	32,334,740 - 32,338,202 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	33,485,381 - 33,488,843 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	31,743,468 - 31,746,930 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	35,413,862 - 35,417,293 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	35,413,793 - 35,417,316 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	39,296,950 - 39,300,381 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	35,195,075 - 35,198,506 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	35,211,149 - 35,214,166 (-)	NCBI
Celera	15	29,891,059 - 29,893,786 (-)	NCBI		Celera
Cytogenetic Map	15	p12	NCBI

GZMB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	4,508,718 - 4,511,824 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	4,470,577 - 4,512,628 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	4,430,126 - 4,433,251 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	4,620,020 - 4,623,146 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	4,601,184 - 4,623,149 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	4,309,346 - 4,312,469 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	4,371,938 - 4,375,062 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	4,634,356 - 4,637,481 (-)	NCBI		UU_Cfam_GSD_1.0

GZMB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	74,705,409 - 74,708,790 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	74,705,499 - 74,708,781 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	79,831,207 - 79,834,515 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GZMB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	1,574,452 - 1,577,861 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	1,574,453 - 1,577,798 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666036	13,270,472 - 13,273,777 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003809116	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000059844 ⟹ ENSPPAP00000036949

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	14	23,523,619 - 23,526,931 (-)	Ensembl

RefSeq Acc Id:

ENSPPAT00000059860 ⟹ ENSPPAP00000036964

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	14	23,523,735 - 23,526,824 (-)	Ensembl

RefSeq Acc Id:

ENSPPAT00000059862 ⟹ ENSPPAP00000036966

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	14	23,523,735 - 23,525,923 (-)	Ensembl

RefSeq Acc Id:

XM_003809116 ⟹ XP_003809164

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	15	25,978,516 - 25,981,806 (-)	NCBI
NHGRI_mPanPan1	14	25,195,008 - 25,198,304 (-)	NCBI
Mhudiblu_PPA_v0	14	5,399,888 - 5,403,200 (-)	NCBI
PanPan1.1	14	23,523,619 - 23,526,931 (-)	NCBI

Sequence:

show sequence

GGAACATGAAGTCACTGAGCCTGCTCCACCTCTTTCCTCTACCAAGAGCTAAAAGAGAGCAAGG
AGGAAACAACAGCAGCTCCAACCAGGGCAGCCTTCCTGAGAAGATGCAACCAATCCTGCTTCTG
CTGGCCTTCCTCCTGCTGCCCAGGGCAGATGCAGGGGAGATCATCGGCGGACATGAGGCCAAGC
CCCACTCCCGCCCCTACATGGCTTATCTTATGATCTGGGATCAGAAGACTCTGAAGAGGTGCGG
TGGCTTCCTGATACGAGAGGACTTCGTGCTGACAGCTGCTCACTGTTGGGGAAGCTCCATAAAT
GTCACCTTGGGGGCCCACAATATCAAGGAACAGGAGCCGACCCAGCAGTTTATCCCTGTGAAAA
GACCCATCCCCCATCCAGCCTATAATCCTAAGAACTACTCCAACGACATCATGCTACTGCAGCT
GGAGAGAAAGGCCAAGCGGACCAGAGCTGTGCAGCCCCTCAGGCTACCTAGCAACAAGGCCCAG
GTGAAGCCAGGGCAGGCGTGCAGTGTGGCCGGCTGGGGGCAGACGGCCCCCCTGGGAAAACACT
CACACACACTACAAGAGGTGAAGATGACAGTGCAGGAAGATCGAAAGTGCGAATCTGACTTACG
CCATTATTACGACAGTACCATTGAGTTGTGCGTGGGGGACCCAGAGATTAAAAAGACTTCCTTT
AAGGGGGACTCTGGAGGCCCTCTTGTGTGTAACAAGGTGGCCCAGGGCATTGTCTCCTATGGAC
GAAACAATGGCATGCCTCCACGAGCCTGCACCAAAGTCTCAAGCTTTGTACACTGGATAAAGAA
AACCATGAAACGCCACTAACTACAGGAAGCAAACTAAGCCCCCGCTGTGATGAAACACCTTCTC
TGGAGCCAAGCCAGATTTACACTGGGAGAGGTGCCAGCAACTGAATAAATACCTCTTAGCTGAG
TGGAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003809164	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000036949.1
	ENSPPAP00000036964.1
	ENSPPAP00000036966.1

RefSeq Acc Id:

XP_003809164 ⟸ XM_003809116

- UniProtKB:

A0A2R9C548 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKSLSLLHLFPLPRAKREQGGNNSSSNQGSLPEKMQPILLLLAFLLLPRADAGEIIGGHEAKPH
SRPYMAYLMIWDQKTLKRCGGFLIREDFVLTAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRP
IPHPAYNPKNYSNDIMLLQLERKAKRTRAVQPLRLPSNKAQVKPGQACSVAGWGQTAPLGKHSH
TLQEVKMTVQEDRKCESDLRHYYDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRN
NGMPPRACTKVSSFVHWIKKTMKRH

hide sequence

RefSeq Acc Id:

ENSPPAP00000036966 ⟸ ENSPPAT00000059862

RefSeq Acc Id:

ENSPPAP00000036964 ⟸ ENSPPAT00000059860

RefSeq Acc Id:

ENSPPAP00000036949 ⟸ ENSPPAT00000059844

Protein Domains

Peptidase S1

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000041223	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000059844.1	UniProtKB/TrEMBL
	ENSPPAT00000059860.1	UniProtKB/TrEMBL
	ENSPPAT00000059862.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.10.10	UniProtKB/TrEMBL
InterPro	Peptidase_S1_PA	UniProtKB/TrEMBL
	Peptidase_S1_PA_chymotrypsin	UniProtKB/TrEMBL
	Peptidase_S1A	UniProtKB/TrEMBL
	Trypsin_dom	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
KEGG Report	pps:100987153	UniProtKB/TrEMBL
NCBI Gene	GZMB	ENTREZGENE
PANTHER	GRANZYME B	UniProtKB/TrEMBL
	KALLIKREIN-RELATED	UniProtKB/TrEMBL
Pfam	Trypsin	UniProtKB/TrEMBL
PRINTS	CHYMOTRYPSIN	UniProtKB/TrEMBL
PROSITE	TRYPSIN_DOM	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
SMART	Tryp_SPc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50494	UniProtKB/TrEMBL
UniProt	A0A2R9C4V1_PANPA	UniProtKB/TrEMBL
	A0A2R9C548	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9C563_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)