ONTOLOGY REPORT - ANNOTATIONS
Term: sphingosine biosynthetic process
Accession: GO:0046512
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Definition: The chemical reactions and pathways resulting in the formation of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.
Synonyms: exact_synonym: sphingosine anabolism; sphingosine biosynthesis; sphingosine formation; sphingosine synthesis
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Abca2
ATP binding cassette subfamily A member 2
acts_upstream_of_positive_effect involved_in
ISO IEA
(PMID:26510981) GO_REF:0000107
RGD Ensembl
PMID:26510981
GO_REF:0000107
NCBI chr 3:8,244,515...8,264,545
Ensembl chr 3:8,244,639...8,264,537
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Acer1
alkaline ceramidase 1
involved_in
ISO IBA
(PMID:17713573), (PMID:20207939), (PMID:20628055) (MGI:5800647|PMID:27126290), (MGI:6107252|PMID:29056331) GO_REF:0000033
RGD GO_Central
PMID:17713573 PMID:20207939 PMID:20628055 PMID:27126290 PMID:29056331
GO_REF:0000033 MGI:5800647 MGI:6107252
NCBI chr 9:1,794,340...1,824,432
Ensembl chr 9:1,793,139...1,824,434
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Acer2
alkaline ceramidase 2
involved_in
ISO IBA
(PMID:16940153), (PMID:20089856), (PMID:20207939), (PMID:20628055) (MGI:6116621|PMID:29401619) GO_REF:0000033
RGD GO_Central
PMID:16940153 PMID:20089856 PMID:20207939 PMID:20628055 PMID:29401619
GO_REF:0000033 MGI:6116621
NCBI chr 5:101,391,830...101,442,615
Ensembl chr 5:101,391,885...101,442,614
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Acer3
alkaline ceramidase 3
involved_in
ISO
(PMID:20068046), (PMID:20207939), (PMID:26792856) (MGI:5749603|PMID:26474409)
RGD
PMID:20068046 PMID:20207939 PMID:26474409 PMID:26792856
MGI:5749603
NCBI chr 1:152,504,180...152,606,596
Ensembl chr 1:152,504,186...152,606,591
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Asah1
N-acylsphingosine amidohydrolase 1
involved_in
ISS IEA ISO
GO_REF:0000024 GO_REF:0000107 (PMID:10610716), (PMID:12815059) (MGI:1267186|PMID:9653654)
UniProt Ensembl RGD
PMID:9653654 PMID:10610716 PMID:12815059
GO_REF:0000024 GO_REF:0000107 MGI:1267186
NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233
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Asah2
N-acylsphingosine amidohydrolase 2
involved_in
IDA ISO IBA
PMID:10488143 (PMID:30154232) PMID:15217782 (MGI:3608219|PMID:16126722), (MGI:3640407|PMID:16380386), (MGI:6275120|PMID:10652340) PMID:15123644 GO_REF:0000033
RGD GO_Central
PMID:10652340 PMID:16126722 PMID:16380386 PMID:30154232 PMID:10488143 PMID:15217782 PMID:15123644 More...
GO_REF:0000033 MGI:3608219 MGI:3640407 MGI:6275120 , RGD:13838800 , RGD:13838794 , RGD:13838793
NCBI chr 1:229,865,662...229,973,253
Ensembl chr 1:229,865,662...229,939,162
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ENSRNOG00000069695
involved_in
IEA
GO_REF:0000117
UniProt
GO_REF:0000117
Ensembl chr14:25,729,638...25,730,194
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Gba1
glucosylceramidase beta 1
involved_in
ISO
(PMID:19279011)
RGD
PMID:19279011
NCBI chr 2:174,609,437...174,615,457
Ensembl chr 2:174,609,403...174,618,263
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Sphk1
sphingosine kinase 1
involved_in
ISO IEA IBA
UniProtKB:Q9NRA0 (PMID:23106337) GO_REF:0000107 GO_REF:0000033
RGD Ensembl GO_Central
PMID:23106337
GO_REF:0000033 GO_REF:0000107
NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
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Sphk2
sphingosine kinase 2
involved_in
ISO IBA
UniProtKB:Q9NYA1 (PMID:23106337) GO_REF:0000033
RGD GO_Central
PMID:23106337
GO_REF:0000033
NCBI chr 1:96,180,872...96,188,592
Ensembl chr 1:96,180,887...96,188,391
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Sptlc1
serine palmitoyltransferase, long chain base subunit 1
involved_in acts_upstream_of_or_within
ISO IBA
(PMID:19416851), (PMID:33558761) GO_REF:0000033 MGI:3815115 (PMID:16216550)
RGD GO_Central
PMID:16216550 PMID:19416851 PMID:33558761
GO_REF:0000033
NCBI chr17:11,877,249...11,916,295
Ensembl chr17:11,877,249...11,916,295
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Sptlc2
serine palmitoyltransferase, long chain base subunit 2
involved_in acts_upstream_of_or_within
ISO IEA IBA
(PMID:19416851), (PMID:33558761) GO_REF:0000107 GO_REF:0000033 MGI:3815117 (PMID:16216550)
RGD Ensembl GO_Central
PMID:16216550 PMID:19416851 PMID:33558761
GO_REF:0000033 GO_REF:0000107
NCBI chr 6:106,948,682...107,031,532
Ensembl chr 6:106,950,949...107,031,542
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Sptlc3
serine palmitoyltransferase, long chain base subunit 3
involved_in
ISO IBA
(PMID:19416851) GO_REF:0000033
RGD GO_Central
PMID:19416851
GO_REF:0000033
NCBI chr 3:126,847,878...126,978,010
Ensembl chr 3:126,847,878...126,978,010
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Sptssa
serine palmitoyltransferase, small subunit A
involved_in
ISO
(PMID:19416851), (PMID:33558761)
RGD
PMID:19416851 PMID:33558761
NCBI chr 6:72,144,714...72,156,130
Ensembl chr 6:72,144,714...72,156,214
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Sptssb
serine palmitoyltransferase, small subunit B
involved_in
ISO
(PMID:19416851)
RGD
PMID:19416851
NCBI chr 2:154,133,728...154,162,127
Ensembl chr 2:154,133,733...154,163,120
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