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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of smoothened signaling pathway
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Accession:GO:0045880 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of smoothened signaling.
Synonyms:exact_synonym: positive regulation of hedgehog signaling pathway;   positive regulation of hh signaling pathway;   positive regulation of smoothened signalling pathway;   up regulation of smoothened signaling pathway;   upregulation of smoothened signaling pathway
 narrow_synonym: activation of smoothened signaling pathway;   stimulation of smoothened signaling pathway
 related_synonym: positive regulation of smoothened by patched;   positive regulation of smoothened receptor activity by patched
 alt_id: GO:0045878


show annotations for term's descendants           Sort by:
positive regulation of smoothened signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARMC9 armadillo repeat containing 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:118,454,310...118,644,303
Ensembl chr2B:237,243,120...237,412,620 		JBrowse link
G CHSY1 chondroitin sulfate synthase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22280990) Ensembl
MGI		 PMID:22280990 GO_REF:0000107 NCBI chr15:79,901,340...79,976,067
Ensembl chr15:99,186,705...99,260,591 		JBrowse link
G CIBAR1 CBY1 interacting BAR domain containing 1 involved_in ISO (MGI:6152361|PMID:29459677) UniProt PMID:29459677 MGI:6152361 NCBI chr 8:90,324,158...90,353,161
Ensembl chr 8:92,270,538...92,298,846 		JBrowse link
G CTNNA1 catenin alpha 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16543460) Ensembl
MGI		 PMID:16543460 GO_REF:0000107 NCBI chr 5:134,134,944...134,313,239
Ensembl chr 5:140,261,883...140,438,547 		JBrowse link
G DCDC2 doublecortin domain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:24,001,971...24,186,530
Ensembl chr 6:24,337,188...24,520,082 		JBrowse link
G DHH desert hedgehog signaling molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:39,656,046...39,661,439
Ensembl chr12:40,535,740...40,541,123 		JBrowse link
G DLG5 discs large MAGUK scaffold protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:74,311,249...74,447,312
Ensembl chr10:76,972,573...77,110,115 		JBrowse link
G DYNC2H1 dynein cytoplasmic 2 heavy chain 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18488998) Ensembl
MGI		 PMID:18488998 GO_REF:0000107 NCBI chr11:98,051,788...98,425,676
Ensembl chr11:101,536,471...101,909,194 		JBrowse link
G EVC EvC ciliary complex subunit 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 4:5,789,316...5,894,265 JBrowse link
G FGF9 fibroblast growth factor 9 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16778080)
(PMID:16540513)		 Ensembl
MGI		 PMID:16540513 PMID:16778080 GO_REF:0000107 NCBI chr13:2,967,713...3,000,554
Ensembl chr13:21,273,333...21,307,198 		JBrowse link
G FOXA1 forkhead box A1 acts_upstream_of_or_within ISO (PMID:23383217) MGI PMID:23383217 NCBI chr14:18,347,284...18,352,705 JBrowse link
G FOXA2 forkhead box A2 acts_upstream_of_or_within ISO (PMID:23383217) MGI PMID:23383217 NCBI chr20:22,519,942...22,524,262 JBrowse link
G GAS1 growth arrest specific 1 acts_upstream_of_or_within ISO (PMID:17504940)
(PMID:17525797)		 MGI PMID:17504940 PMID:17525797 NCBI chr 9:58,079,700...58,082,849
Ensembl chr 9:86,139,009...86,140,045 		JBrowse link
G GAS8 growth arrest specific 8 involved_in ISO (MGI:6148647|PMID:21659505) UniProt PMID:21659505 MGI:6148647 NCBI chr16:70,777,446...70,806,437
Ensembl chr16:90,444,141...90,467,849 		JBrowse link
G GLI1 GLI family zinc finger 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:31,453,759...31,466,194
Ensembl chr12:31,710,057...31,722,473 		JBrowse link
G GORAB golgin, RAB6 interacting involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:26967474) Ensembl
MGI		 PMID:26967474 GO_REF:0000107 NCBI chr 1:146,020,446...146,042,334
Ensembl chr 1:149,736,641...149,758,010 		JBrowse link
G GPC3 glypican 3 acts_upstream_of_or_within ISO (PMID:19733558) MGI PMID:19733558 NCBI chr  X:122,677,072...123,131,511
Ensembl chr  X:132,979,612...133,432,441 		JBrowse link
G IFT172 intraflagellar transport 172 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18488998) Ensembl
MGI		 PMID:18488998 GO_REF:0000107 NCBI chr2A:27,448,139...27,492,302
Ensembl chr2A:27,536,534...27,580,406 		JBrowse link
G IHH Indian hedgehog signaling molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:106,312,472...106,319,124
Ensembl chr2B:224,906,271...224,911,506 		JBrowse link
G INTU inturned planar cell polarity protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22935613) Ensembl
MGI		 PMID:22935613 GO_REF:0000107 NCBI chr 4:119,793,245...119,890,949
Ensembl chr 4:131,109,733...131,186,590 		JBrowse link
G ISL1 ISL LIM homeobox 1 ISO RGD PMID:32544883 RGD:243065126 NCBI chr 5:62,635,095...62,650,141
Ensembl chr 5:64,252,715...64,264,674 		JBrowse link
G KIF7 kinesin family member 7 involved_in ISO (MGI:4355635|PMID:19666503), (MGI:4357736|PMID:19549984) UniProt PMID:19549984 PMID:19666503 MGI:4355635 MGI:4357736 NCBI chr15:68,312,064...68,349,864
Ensembl chr15:87,529,290...87,553,445 		JBrowse link
G LOC100990437 NADPH--cytochrome P450 reductase ISO RGD PMID:19264869 RGD:2316785 NCBI chr 7:68,035,021...68,105,934
Ensembl chr 7:82,364,418...82,437,530 		JBrowse link
G NDST1 N-deacetylase and N-sulfotransferase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16020517) Ensembl
MGI		 PMID:16020517 GO_REF:0000107 NCBI chr 5:145,910,993...145,982,933
Ensembl chr 5:151,936,357...151,986,668 		JBrowse link
G PDCL phosducin like involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:93,949,613...93,959,913
Ensembl chr 9:122,283,877...122,294,174 		JBrowse link
G PRRX1 paired related homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11532916) Ensembl
MGI		 PMID:11532916 GO_REF:0000107 NCBI chr 1:146,151,633...146,227,926
Ensembl chr 1:149,867,634...149,943,810 		JBrowse link
G PRRX2 paired related homeobox 2 acts_upstream_of_or_within ISO (PMID:11532916) MGI PMID:11532916 NCBI chr 9:100,792,324...100,849,923 JBrowse link
G RAB34 RAB34, member RAS oncogene family involved_in ISO (MGI:6111022|PMID:29290584) UniProt PMID:29290584 MGI:6111022 NCBI chr17:28,057,077...28,061,234
Ensembl chr17:28,562,118...28,566,242 		JBrowse link
G SCUBE1 signal peptide, CUB domain and EGF like domain containing 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25639508) Ensembl
MGI		 PMID:25639508 GO_REF:0000107 NCBI chr22:24,080,438...24,228,401
Ensembl chr22:42,285,374...42,420,761 		JBrowse link
G SCUBE2 signal peptide, CUB domain and EGF like domain containing 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25639508) Ensembl
MGI		 PMID:25639508 GO_REF:0000107 NCBI chr11:9,146,533...9,219,816
Ensembl chr11:8,888,668...8,959,677 		JBrowse link
G SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 acts_upstream_of_or_within ISO (PMID:25639508) MGI PMID:25639508 NCBI chr 6:34,776,605...34,815,808
Ensembl chr 6:35,872,590...35,911,272 		JBrowse link
G SFRP1 secreted frizzled related protein 1 involved_in ISO (PMID:17035233) UniProt PMID:17035233 NCBI chr 8:40,507,027...40,555,053 JBrowse link
G SHH sonic hedgehog signaling molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:147,400,112...147,414,036
Ensembl chr 7:159,114,666...159,126,651 		JBrowse link
G SHOX2 SHOX homeobox 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17481601) Ensembl
MGI		 PMID:17481601 GO_REF:0000107 NCBI chr 3:155,138,969...155,149,619
Ensembl chr 3:163,190,284...163,199,239 		JBrowse link
G SKOR2 SKI family transcriptional corepressor 2 acts_upstream_of_or_within ISO (PMID:21937600) MGI PMID:21937600 NCBI chr18:40,594,124...40,639,720 JBrowse link
G SMO smoothened, frizzled class receptor acts_upstream_of_or_within ISO (PMID:16459297) MGI PMID:16459297 NCBI chr 7:121,143,968...121,168,873
Ensembl chr 7:133,668,304...133,693,048 		JBrowse link
G STK36 serine/threonine kinase 36 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:105,930,030...105,960,718
Ensembl chr2B:224,525,226...224,555,583 		JBrowse link
G TEDC1 tubulin epsilon and delta complex 1 involved_in ISO (MGI:6152361|PMID:29459677) UniProt PMID:29459677 MGI:6152361 NCBI chr14:86,153,559...86,159,324
Ensembl chr14:105,916,697...105,925,911 		JBrowse link
G TEDC2 tubulin epsilon and delta complex 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:1,316,181...1,321,075
Ensembl chr16:2,559,493...2,564,370 		JBrowse link
G TTC23 tetratricopeptide repeat domain 23 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:77,821,847...77,932,769
Ensembl chr15:97,005,675...97,116,569 		JBrowse link
G TUBD1 tubulin delta 1 involved_in ISO (MGI:6111022|PMID:29290584) UniProt PMID:29290584 MGI:6111022 NCBI chr17:53,925,234...53,958,706
Ensembl chr17:58,766,864...58,798,842 		JBrowse link
G TXNDC15 thioredoxin domain containing 15 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:130,275,685...130,301,164
Ensembl chr 5:136,417,859...136,443,185 		JBrowse link
G UCHL5 ubiquitin C-terminal hydrolase L5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:168,471,501...168,519,366
Ensembl chr 1:172,764,606...172,811,880 		JBrowse link
G ULK3 unc-51 like kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:53,778,676...53,785,754
Ensembl chr15:73,396,341...73,403,362 		JBrowse link
G WNT9A Wnt family member 9A acts_upstream_of_or_within ISO (PMID:16818445) MGI PMID:16818445 NCBI chr 1:203,320,990...203,350,599
Ensembl chr 1:208,300,609...208,327,191 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16447
    response to stimulus 8499
      positive regulation of response to stimulus 2359
        positive regulation of signal transduction 1645
          positive regulation of smoothened signaling pathway 45
            positive regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning 0
Path 2
Term Annotations click to browse term
  biological_process 16447
    biological regulation 11461
      regulation of biological process 11108
        signaling 5929
          signal transduction 5431
            cell surface receptor signaling pathway 2632
              smoothened signaling pathway 166
                regulation of smoothened signaling pathway 100
                  positive regulation of smoothened signaling pathway 45
                    positive regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning 0
paths to the root