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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:TRIF-dependent toll-like receptor signaling pathway
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Accession:GO:0035666 term browser browse the term
Definition:The series of molecular signals initiated by a ligand binding to a toll-like receptor where the TRIF adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response.
Synonyms:exact_synonym: TRIF-dependent TLR signaling pathway;   TRIF-dependent toll-like receptor signalling pathway;   Toll/IL-1 receptor (TIR) domain-containing adaptor-dependent TLR signaling pathway


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TRIF-dependent toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD274 CD274 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:216,646,378...216,792,731
Ensembl chr 1:216,660,041...216,792,724 		JBrowse link
G CD300LF CD300 molecule like family member f involved_in ISO (PMID:22043923) UniProt PMID:22043923 NCBI chr12:6,501,151...6,521,135 JBrowse link
G CD40 CD40 molecule involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr17:48,286,116...48,298,188
Ensembl chr17:48,286,029...48,298,528 		JBrowse link
G IRF3 interferon regulatory factor 3 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:54,701,733...54,706,079
Ensembl chr 6:54,701,668...54,707,151 		JBrowse link
G TICAM1 TIR domain containing adaptor molecule 1 involved_in IEA
IBA		 Ensembl
InterPro
TreeGrafter
GO_Central		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:74,004,566...74,021,100
Ensembl chr 2:74,004,308...74,021,873 		JBrowse link
G TICAM2 toll like receptor adaptor molecule 2 involved_in IEA
IBA		 InterPro
GO_Central
TreeGrafter		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118 NCBI chr 2:119,758,622...119,778,650 JBrowse link
G TLR4 toll like receptor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970 		JBrowse link
G TLR6 toll like receptor 6 involved_in ISO (MGI:4438693|PMID:20037584) ARUK-UCL PMID:20037584 MGI:4438693 NCBI chr 8:30,159,744...30,180,650
Ensembl chr 8:30,159,754...30,180,650 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17805
    immune system process 2496
      activation of immune response 520
        activation of innate immune response 287
          innate immune response-activating signaling pathway 266
            pattern recognition receptor signaling pathway 256
              toll-like receptor signaling pathway 74
                MyD88-independent toll-like receptor signaling pathway 14
                  TRIF-dependent toll-like receptor signaling pathway 8
                    TRIF-dependent toll-like receptor 4 signaling pathway 0
Path 2
Term Annotations click to browse term
  biological_process 17805
    response to stimulus 10056
      response to biotic stimulus 1716
        response to external biotic stimulus 1673
          response to other organism 1669
            defense response to other organism 1151
              defense response to symbiont 1034
                innate immune response 837
                  regulation of innate immune response 425
                    positive regulation of innate immune response 351
                      activation of innate immune response 287
                        innate immune response-activating signaling pathway 266
                          pattern recognition receptor signaling pathway 256
                            toll-like receptor signaling pathway 74
                              MyD88-independent toll-like receptor signaling pathway 14
                                TRIF-dependent toll-like receptor signaling pathway 8
                                  TRIF-dependent toll-like receptor 4 signaling pathway 0
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