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ONTOLOGY REPORT - ANNOTATIONS

Term:translesion synthesis
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Accession:GO:0019985 term browser browse the term
Definition:The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide.
Synonyms:exact_synonym: bypass DNA synthesis


show annotations for term's descendants           Sort by:
translesion synthesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dtl denticleless E3 ubiquitin protein ligase homolog involved_in ISO (PMID:20129063) RGD PMID:20129063 NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890 		JBrowse link
G Faap20 FA core complex associated protein 20 involved_in ISO
ISS		 (PMID:22266823)
GO_REF:0000024		 RGD
UniProt		 PMID:22266823 GO_REF:0000024 NCBI chr 5:165,808,370...165,815,291
Ensembl chr 5:165,808,657...165,815,333 		JBrowse link
G Parp10 poly (ADP-ribose) polymerase family, member 10 involved_in ISO (PMID:24695737) RGD PMID:24695737 NCBI chr 7:107,949,031...107,958,377
Ensembl chr 7:107,949,043...107,958,304 		JBrowse link
G Pclaf PCNA clamp associated factor involved_in ISO
IBA
ISS		 (PMID:23000965)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:23000965 GO_REF:0000024 GO_REF:0000033 NCBI chr 8:66,420,606...66,432,994
Ensembl chr 8:66,420,587...66,432,994
Ensembl chr 8:66,420,587...66,432,994 		JBrowse link
G Pcna proliferating cell nuclear antigen involved_in ISO
ISS
IBA		 (PMID:20129063)
GO_REF:0000024
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:20129063 GO_REF:0000024 GO_REF:0000033 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Poli DNA polymerase iota involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:3055735 (PMID:17114294)		 GO_Central
RGD		 PMID:17114294 GO_REF:0000033 NCBI chr18:64,116,774...64,134,373
Ensembl chr18:64,116,774...64,163,418 		JBrowse link
G Poln DNA polymerase nu involved_in ISO (PMID:19908865), (PMID:20102227) RGD PMID:19908865 PMID:20102227 NCBI chr14:76,579,983...76,752,460
Ensembl chr14:76,580,546...76,752,463 		JBrowse link
G Primpol primase and DNA directed polymerase involved_in ISO
IBA		 (PMID:24240614), (PMID:24267451)
GO_REF:0000033		 RGD
GO_Central		 PMID:24240614 PMID:24267451 GO_REF:0000033 NCBI chr16:45,681,252...45,715,758
Ensembl chr16:45,681,326...45,715,565 		JBrowse link
G Sprtn SprT-like N-terminal domain involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:22681887), (PMID:22902628), (PMID:23042605), (PMID:23042607)		 Ensembl
UniProt
RGD		 PMID:22681887 PMID:22902628 PMID:23042605 PMID:23042607 GO_REF:0000024 GO_REF:0000107 NCBI chr19:52,857,612...52,864,864
Ensembl chr19:52,857,866...52,864,864 		JBrowse link
G Vcp valosin-containing protein involved_in ISO
ISS		 (PMID:23042605)
GO_REF:0000024		 RGD
UniProt		 PMID:23042605 GO_REF:0000024 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571 		JBrowse link
G Zbtb1 zinc finger and BTB domain containing 1 involved_in ISO (PMID:24657165) RGD PMID:24657165 NCBI chr 6:95,096,838...95,125,811
Ensembl chr 6:95,096,387...95,118,996 		JBrowse link
error-free translesion synthesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pold1 DNA polymerase delta 1, catalytic subunit involved_in ISO
ISS
IEA		 (PMID:24191025)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:24191025 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:95,025,462...95,041,559
Ensembl chr 1:95,025,499...95,036,465 		JBrowse link
G Poldip2 DNA polymerase delta interacting protein 2 involved_in ISO
IBA		 (PMID:24191025)
GO_REF:0000033		 RGD
GO_Central		 PMID:24191025 GO_REF:0000033 NCBI chr10:63,407,237...63,417,605
Ensembl chr10:63,407,213...63,417,605 		JBrowse link
G Rev1 REV1, DNA directed polymerase involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:40,278,100...40,351,764
Ensembl chr 9:40,278,101...40,351,576 		JBrowse link
error-prone translesion synthesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mad2l2 mitotic arrest deficient 2 like 2 involved_in ISO (PMID:24449906) RGD PMID:24449906 NCBI chr 5:158,563,545...158,576,698
Ensembl chr 5:158,563,567...158,576,693 		JBrowse link
G Pold2 DNA polymerase delta 2, accessory subunit involved_in ISO
IEA		 (PMID:24449906)
GO_REF:0000107		 RGD
Ensembl		 PMID:24449906 GO_REF:0000107 NCBI chr14:80,748,971...80,755,188
Ensembl chr14:80,748,974...80,755,160 		JBrowse link
G Pold3 DNA polymerase delta 3, accessory subunit involved_in ISO (PMID:24449906) RGD PMID:24449906 NCBI chr 1:154,417,893...154,456,687
Ensembl chr 1:154,418,084...154,456,665 		JBrowse link
G Pole2 DNA polymerase epsilon 2, accessory subunit involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:87,674,702...87,712,723
Ensembl chr 6:87,674,702...87,699,305 		JBrowse link
G Polh DNA polymerase eta involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:14,778,355...14,813,210
Ensembl chr 9:14,777,888...14,812,723 		JBrowse link
G Polk DNA polymerase kappa involved_in ISO
IBA		 (PMID:28297716)
GO_REF:0000033		 RGD
GO_Central		 PMID:28297716 GO_REF:0000033 NCBI chr 2:27,822,228...27,882,331
Ensembl chr 2:27,822,679...27,882,313 		JBrowse link
G Polq DNA polymerase theta involved_in ISO (PMID:30655289) RGD PMID:30655289 NCBI chr11:63,673,796...63,775,905
Ensembl chr11:63,673,816...63,775,878 		JBrowse link
G Primpol primase and DNA directed polymerase involved_in ISO (PMID:24682820), (PMID:25746449), (PMID:28534480) RGD PMID:24682820 PMID:25746449 PMID:28534480 NCBI chr16:45,681,252...45,715,758
Ensembl chr16:45,681,326...45,715,565 		JBrowse link
G Rev1 REV1, DNA directed polymerase involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:11711549)		 GO_Central
RGD		 PMID:11711549 GO_REF:0000033 NCBI chr 9:40,278,100...40,351,764
Ensembl chr 9:40,278,101...40,351,576 		JBrowse link
G Rev3l REV3 like, DNA directed polymerase zeta catalytic subunit involved_in ISO
IBA		 (PMID:24449906)
GO_REF:0000033		 RGD
GO_Central		 PMID:24449906 GO_REF:0000033 NCBI chr20:43,131,841...43,290,102
Ensembl chr20:43,132,363...43,290,099 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19692
    cellular process 18195
      cellular response to stimulus 8802
        cellular response to stress 1993
          DNA damage response 860
            DNA repair 545
              DNA synthesis involved in DNA repair 35
                translesion synthesis 22
                  error-free translesion synthesis 3
                  error-prone translesion synthesis + 10
Path 2
Term Annotations click to browse term
  biological_process 19692
    metabolic process 11456
      organic substance metabolic process 10970
        organic cyclic compound metabolic process 6031
          organic cyclic compound biosynthetic process 4707
            nucleobase-containing compound biosynthetic process 4454
              nucleic acid biosynthetic process 4203
                DNA biosynthetic process 177
                  DNA synthesis involved in DNA repair 35
                    translesion synthesis 22
                      error-free translesion synthesis 3
                      error-prone translesion synthesis + 10
paths to the root