Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of tumor necrosis factor-mediated signaling pathway
go back to main search page
Accession:GO:0010804 term browser browse the term
Definition:Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
Synonyms:exact_synonym: negative regulation of TNF signaling;   negative regulation of TNF-mediated signaling pathway;   negative regulation of tumor necrosis factor-mediated signalling pathway


show annotations for term's descendants           Sort by:
negative regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISS
ISO		 GO_REF:0000024
(PMID:10604883)		 UniProt
RGD		 PMID:10604883 GO_REF:0000024 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Apoa1 apolipoprotein A1 involved_in ISO
IEA		 (PMID:21571275)
GO_REF:0000107		 RGD
Ensembl		 PMID:21571275 GO_REF:0000107 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Birc7 baculoviral IAP repeat-containing 7 involved_in ISO (PMID:11865055) RGD PMID:11865055 NCBI chr 3:168,047,824...168,052,606
Ensembl chr 3:168,047,824...168,052,606 		JBrowse link
G Ccdc3 coiled-coil domain containing 3 involved_in ISO (PMID:25193116) RGD PMID:25193116 NCBI chr17:73,031,891...73,135,173
Ensembl chr17:73,035,045...73,135,337 		JBrowse link
G Cldn18 claudin 18 acts_upstream_of_or_within ISO MGI:5007067 (PMID:22437732) RGD PMID:22437732 NCBI chr 8:100,246,499...100,265,797
Ensembl chr 8:100,247,633...100,273,351 		JBrowse link
G Dicer1 dicer 1 ribonuclease III acts_upstream_of ISO (PMID:26435691) RGD PMID:26435691 NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISO (PMID:19781631) RGD PMID:19781631 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226 		JBrowse link
G Gas6 growth arrest specific 6 involved_in ISO
ISS		 (PMID:19657094)
GO_REF:0000024		 RGD
UniProt		 PMID:19657094 GO_REF:0000024 NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904 		JBrowse link
G Gps2 G protein pathway suppressor 2 involved_in ISO (MGI:6148454|PMID:22424771) RGD PMID:22424771 MGI:6148454 NCBI chr10:54,637,360...54,640,542
Ensembl chr10:54,637,455...54,640,650 		JBrowse link
G Hist2h2be histone cluster 2 H2B family member E involved_in ISO (PMID:11859126) RGD PMID:11859126 NCBI chr 2:183,780,583...183,783,030 JBrowse link
G Mir125b1 microRNA 125b-1 acts_upstream_of ISO (PMID:26435691) RGD PMID:26435691 NCBI chr 8:41,952,966...41,953,052
Ensembl chr 8:41,952,966...41,953,052 		JBrowse link
G Mir125b2 microRNA 125b-2 acts_upstream_of ISO (PMID:26435691) RGD PMID:26435691 NCBI chr11:16,245,620...16,245,707 JBrowse link
G Mir130a microRNA 130a acts_upstream_of ISO (PMID:26435691) RGD PMID:26435691 NCBI chr 3:69,822,542...69,822,629
Ensembl chr 3:69,822,542...69,822,629 		JBrowse link
G Mir152 microRNA 152 involved_in ISO (PMID:24813629) RGD PMID:24813629 NCBI chr10:81,832,936...81,833,020
Ensembl chr10:81,832,936...81,833,020 		JBrowse link
G Mir27b microRNA 27b acts_upstream_of_or_within ISO UniProtKB:P01375 (PMID:31124343) RGD PMID:31124343 NCBI chr17:1,813,427...1,813,523
Ensembl chr17:1,813,426...1,813,529 		JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 involved_in ISO (PMID:11865055) RGD PMID:11865055 NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542 		JBrowse link
G Nol3 nucleolar protein 3 involved_in IEA
ISO		 GO_REF:0000107
(MGI:5617337|PMID:24440909)		 Ensembl
RGD		 PMID:24440909 GO_REF:0000107 MGI:5617337 NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 involved_in ISO
IEA		 (MGI:5707586|PMID:18972444)
GO_REF:0000107		 RGD
Ensembl		 PMID:18972444 GO_REF:0000107 MGI:5707586 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Peli3 pellino E3 ubiquitin protein ligase family member 3 acts_upstream_of_or_within ISO (PMID:24113711)
MGI:5441750 (PMID:23950925)		 RGD PMID:23950925 PMID:24113711 NCBI chr 1:202,230,034...202,242,900
Ensembl chr 1:202,232,228...202,242,857 		JBrowse link
G Pias4 protein inhibitor of activated STAT, 4 acts_upstream_of_or_within ISO (PMID:20054338) RGD PMID:20054338 NCBI chr 7:8,546,312...8,559,838
Ensembl chr 7:8,546,312...8,559,808 		JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta acts_upstream_of ISO UniProtKB:P01375 (PMID:28159925) RGD PMID:28159925 NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:3530208|PMID:15696169)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:15696169 GO_REF:0000024 GO_REF:0000107 MGI:3530208 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase involved_in ISO
ISS
IEA		 (PMID:18450452)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:18450452 GO_REF:0000024 GO_REF:0000107 NCBI chr10:67,740,711...67,803,669
Ensembl chr10:67,740,712...67,824,434 		JBrowse link
G Tank TRAF family member-associated NFKB activator involved_in ISO (PMID:8710854) RGD PMID:8710854 NCBI chr 3:46,114,230...46,190,270
Ensembl chr 3:46,114,274...46,190,264 		JBrowse link
G Tjp2 tight junction protein 2 acts_upstream_of_or_within ISO (PMID:22437732) RGD PMID:22437732 NCBI chr 1:221,709,745...221,838,291
Ensembl chr 1:221,709,745...221,838,295 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B acts_upstream_of_or_within ISO (PMID:29415886) RGD PMID:29415886 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Traip TRAF-interacting protein involved_in ISO (PMID:19151749) RGD PMID:19151749 NCBI chr 8:108,641,860...108,661,640
Ensembl chr 8:108,641,852...108,661,638 		JBrowse link
G Xiap X-linked inhibitor of apoptosis involved_in ISO
IEA		 (PMID:11865055)
GO_REF:0000107		 RGD
Ensembl		 PMID:11865055 GO_REF:0000107 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19694
    cellular process 18196
      signal transduction 7020
        negative regulation of signal transduction 1446
          negative regulation of cytokine-mediated signaling pathway 93
            negative regulation of tumor necrosis factor-mediated signaling pathway 28
Path 2
Term Annotations click to browse term
  biological_process 19694
    biological regulation 13309
      regulation of biological process 12906
        signaling 7595
          signal transduction 7020
            cell surface receptor signaling pathway 2814
              cytokine-mediated signaling pathway 484
                regulation of cytokine-mediated signaling pathway 164
                  negative regulation of cytokine-mediated signaling pathway 93
                    negative regulation of tumor necrosis factor-mediated signaling pathway 28
paths to the root