Birc7 (baculoviral IAP repeat-containing 7) - Rat Genome Database

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Gene: Birc7 (baculoviral IAP repeat-containing 7) Rattus norvegicus
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Symbol: Birc7
Name: baculoviral IAP repeat-containing 7
RGD ID: 1562883
Description: Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of protein ubiquitination; regulation of apoptotic process; and regulation of signal transduction. Predicted to act upstream of with a negative effect on regulation of apoptotic process. Predicted to act upstream of or within lens development in camera-type eye. Predicted to be located in several cellular components, including Golgi apparatus; centrosome; and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human BIRC7 (baculoviral IAP repeat containing 7); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: baculoviral IAP repeat-containing 7 (livin); baculoviral IAP repeat-containing protein 7; LOC296468; RGD1562883; similar to livin inhibitor of apoptosis isoform beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83188,425,392 - 188,430,174 (+)NCBIGRCr8
mRatBN7.23168,047,824 - 168,052,606 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3168,047,824 - 168,052,606 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3172,428,000 - 172,432,781 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03181,387,091 - 181,391,872 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03178,048,785 - 178,053,567 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03176,438,335 - 176,443,864 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3176,439,199 - 176,443,195 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03180,150,723 - 180,153,671 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43170,037,778 - 170,043,277 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3164,532,360 - 164,537,207 (-)NCBICelera
Cytogenetic Map3q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Expression patterns of inhibitor of apoptosis proteins in malignant pleural mesothelioma. Gordon GJ, etal., J Pathol. 2007 Mar;211(4):447-54. doi: 10.1002/path.2121.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. [Expression and significance of JNK1, Raf-1 and Livin in the carcinogenesis of sporadic colorectal tubular adenoma]. Wu WX, etal., Zhonghua Zhong Liu Za Zhi. 2010 Sep;32(9):671-5.
Additional References at PubMed
PMID:16729033   PMID:17294084   PMID:18034418   PMID:21617971   PMID:26218911  


Genomics

Comparative Map Data
Birc7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83188,425,392 - 188,430,174 (+)NCBIGRCr8
mRatBN7.23168,047,824 - 168,052,606 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3168,047,824 - 168,052,606 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3172,428,000 - 172,432,781 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03181,387,091 - 181,391,872 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03178,048,785 - 178,053,567 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03176,438,335 - 176,443,864 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3176,439,199 - 176,443,195 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03180,150,723 - 180,153,671 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43170,037,778 - 170,043,277 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3164,532,360 - 164,537,207 (-)NCBICelera
Cytogenetic Map3q43NCBI
BIRC7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382063,235,905 - 63,240,495 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2063,235,883 - 63,240,495 (+)EnsemblGRCh38hg38GRCh38
GRCh372061,867,257 - 61,871,847 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362061,337,721 - 61,342,299 (+)NCBINCBI36Build 36hg18NCBI36
Build 342061,337,720 - 61,342,299NCBI
Celera2058,544,759 - 58,549,338 (+)NCBICelera
Cytogenetic Map20q13.33NCBI
HuRef2058,592,772 - 58,597,397 (+)NCBIHuRef
CHM1_12061,768,290 - 61,772,915 (+)NCBICHM1_1
T2T-CHM13v2.02065,041,538 - 65,046,510 (+)NCBIT2T-CHM13v2.0
Birc7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392180,570,402 - 180,575,803 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2180,570,816 - 180,575,803 (+)EnsemblGRCm39 Ensembl
GRCm382180,928,609 - 180,934,010 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2180,929,023 - 180,934,010 (+)EnsemblGRCm38mm10GRCm38
MGSCv372180,663,728 - 180,668,715 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362180,850,322 - 180,862,738 (+)NCBIMGSCv36mm8
Celera2185,015,239 - 185,020,226 (+)NCBICelera
Cytogenetic Map2H4NCBI
cM Map2103.53NCBI
Birc7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955528919,246 - 922,619 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955528919,246 - 922,581 (-)NCBIChiLan1.0ChiLan1.0
BIRC7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22169,022,107 - 69,027,217 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12069,014,113 - 69,019,185 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02059,618,530 - 59,623,612 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12061,156,871 - 61,161,932 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2061,157,302 - 61,161,932 (+)Ensemblpanpan1.1panPan2
BIRC7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12446,950,700 - 46,956,375 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2446,952,474 - 46,955,495 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2446,136,510 - 46,140,424 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02447,906,319 - 47,910,219 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2447,906,319 - 47,909,340 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12446,921,701 - 46,925,622 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02447,045,709 - 47,049,636 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02447,802,069 - 47,805,983 (+)NCBIUU_Cfam_GSD_1.0
Birc7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640195,164,678 - 195,169,263 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651410,618,289 - 10,622,931 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651410,618,347 - 10,622,906 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BIRC7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11762,351,663 - 62,356,220 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
BIRC7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12965,811 - 970,983 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605048,703,511 - 48,708,637 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Birc7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474128,937,836 - 28,944,000 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Birc7
8 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:71
Count of miRNA genes:61
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000068252
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3161192952169034231Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat

Markers in Region
RH134165  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23168,051,897 - 168,052,549 (+)MAPPERmRatBN7.2
Rnor_6.03176,443,149 - 176,443,800NCBIRnor6.0
Rnor_5.03180,152,963 - 180,153,614UniSTSRnor5.0
RGSC_v3.43170,042,569 - 170,043,220UniSTSRGSC3.4
Celera3164,532,417 - 164,533,068UniSTS
RH 3.4 Map31532.2UniSTS
Cytogenetic Map3q43UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 8 41 4 9
Below cutoff 15 17 7 6 7 2 2 31 6 20 2 2

Sequence


RefSeq Acc Id: ENSRNOT00000068252   ⟹   ENSRNOP00000059533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,047,824 - 168,052,606 (+)Ensembl
Rnor_6.0 Ensembl3176,439,199 - 176,443,195 (+)Ensembl
RefSeq Acc Id: NM_001305210   ⟹   NP_001292139
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83188,425,392 - 188,430,174 (+)NCBI
mRatBN7.23168,047,824 - 168,052,606 (+)NCBI
Rnor_6.03176,439,075 - 176,443,857 (+)NCBI
Celera3164,532,360 - 164,537,207 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001292139 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL88780 (Get FASTA)   NCBI Sequence Viewer  
  EDL88781 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000059533
  ENSRNOP00000059533.3
RefSeq Acc Id: NP_001292139   ⟸   NM_001305210
- UniProtKB: D4A690 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000059533   ⟸   ENSRNOT00000068252
Protein Domains
RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A690-F1-model_v2 AlphaFold D4A690 1-285 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562883 AgrOrtholog
BioCyc Gene G2FUF-46312 BioCyc
Ensembl Genes ENSRNOG00000043311 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068252 ENTREZGENE
  ENSRNOT00000068252.4 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
InterPro BIR UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/TrEMBL
KEGG Report rno:296468 UniProtKB/TrEMBL
NCBI Gene 296468 ENTREZGENE
PANTHER BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 7 UniProtKB/TrEMBL
  INHIBITOR OF APOPTOSIS UniProtKB/TrEMBL
Pfam BIR UniProtKB/TrEMBL
  zf-C3HC4_3 UniProtKB/TrEMBL
PhenoGen Birc7 PhenoGen
PROSITE BIR_REPEAT_1 UniProtKB/TrEMBL
  BIR_REPEAT_2 UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000043311 RatGTEx
SMART BIR UniProtKB/TrEMBL
  RING UniProtKB/TrEMBL
Superfamily-SCOP Inhibitor of apoptosis (IAP) repeat UniProtKB/TrEMBL
UniProt D4A690 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-26 Birc7  baculoviral IAP repeat-containing 7  Birc7  baculoviral IAP repeat-containing 7 (livin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Birc7  baculoviral IAP repeat-containing 7 (livin)  RGD1562883_predicted  similar to livin inhibitor of apoptosis isoform beta (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1562883_predicted  similar to livin inhibitor of apoptosis isoform beta (predicted)  LOC296468  similar to livin inhibitor of apoptosis isoform beta  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC296468  similar to livin inhibitor of apoptosis isoform beta      Symbol and Name status set to provisional 70820 PROVISIONAL