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ONTOLOGY REPORT - ANNOTATIONS

Term:dosage compensation by inactivation of X chromosome
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Accession:GO:0009048 term browser browse the term
Definition:Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by heterochromatin formation leading to a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex.
Synonyms:exact_synonym: X chromosome inactivation
 broad_synonym: chromosome inactivation
 related_synonym: Barr body formation
 xref: Wikipedia:X-inactivation
 only_in_taxon: NCBITaxon:32524 ! Amniota
 never_in_taxon: NCBITaxon:8782 ! Aves


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dosage compensation by inactivation of X chromosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hnrnpu heterogeneous nuclear ribonucleoprotein U involved_in ISO (MGI:4831049|PMID:20833368) RGD PMID:20833368 MGI:4831049 NCBI chr13:90,069,058...90,086,905
Ensembl chr13:90,074,181...90,086,588 		JBrowse link
G Lrif1 ligand dependent nuclear receptor interacting factor 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:23542155)		 UniProt
Ensembl
RGD		 PMID:23542155 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:194,231,397...194,322,489
Ensembl chr 2:194,230,951...194,322,483 		JBrowse link
G Mettl3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit involved_in ISO (PMID:27602518) RGD PMID:27602518 NCBI chr15:25,002,505...25,014,097
Ensembl chr15:25,003,172...25,014,041 		JBrowse link
G Rbm15 RNA binding motif protein 15 involved_in ISO (PMID:27602518) RGD PMID:27602518 NCBI chr 2:194,945,974...194,954,498
Ensembl chr 2:194,945,974...194,954,703 		JBrowse link
G Rbm15b RNA binding motif protein 15B involved_in ISO (PMID:27602518) RGD PMID:27602518 NCBI chr 8:107,543,613...107,546,678
Ensembl chr 8:107,525,898...107,551,696 		JBrowse link
G Smchd1 structural maintenance of chromosomes flexible hinge domain containing 1 involved_in ISO (PMID:23542155) RGD PMID:23542155 NCBI chr 9:111,243,445...111,387,272
Ensembl chr 9:111,247,702...111,349,665 		JBrowse link
G Ythdc1 YTH N6-methyladenosine RNA binding protein C1 involved_in ISO
ISS		 (PMID:27602518)
GO_REF:0000024		 RGD
UniProt		 PMID:27602518 GO_REF:0000024 NCBI chr14:21,185,438...21,215,934
Ensembl chr14:21,185,440...21,216,028 		JBrowse link
inactivation of paternal X chromosome by genomic imprinting term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prdm14 PR/SET domain 14 acts_upstream_of_or_within ISO MGI:3805889 (PMID:24268575) RGD PMID:24268575 NCBI chr 5:6,082,163...6,092,712
Ensembl chr 5:6,082,442...6,092,712 		JBrowse link
G Smchd1 structural maintenance of chromosomes flexible hinge domain containing 1 acts_upstream_of_or_within ISO MGI:3586547 (PMID:18425126), (PMID:23754746) RGD PMID:18425126 PMID:23754746 NCBI chr 9:111,243,445...111,387,272
Ensembl chr 9:111,247,702...111,349,665 		JBrowse link
G Xist X inactive specific transcript acts_upstream_of_or_within ISO MGI:1336196|MGI:2445460 (PMID:15992549), (PMID:22573614), (PMID:23658530) RGD PMID:15992549 PMID:22573614 PMID:23658530 NCBI chr  X:68,474,987...68,492,500 JBrowse link
random inactivation of X chromosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca1 BRCA1, DNA repair associated involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:98974 (PMID:12419249)		 Ensembl
RGD		 PMID:12419249 GO_REF:0000107 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Cdyl chromodomain Y-like involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:5551942|PMID:24144980)		 UniProt
Ensembl
RGD		 PMID:24144980 GO_REF:0000024 GO_REF:0000107 MGI:5551942 NCBI chr17:28,982,009...29,204,345
Ensembl chr17:28,982,037...29,204,313 		JBrowse link
G Ftx FTX transcript, XIST regulator acts_upstream_of_or_within ISO MGI:1342291|MGI:2180008 (PMID:21118898), (PMID:24613346) RGD PMID:21118898 PMID:24613346 NCBI chr  X:68,588,349...68,630,338 JBrowse link
G Jarid2 jumonji and AT-rich interaction domain containing 2 acts_upstream_of_or_within ISO MGI:5888989 (PMID:27892467) RGD PMID:27892467 NCBI chr17:19,777,487...19,957,696
Ensembl chr17:19,777,266...19,955,690 		JBrowse link
G Jpx JPX transcript, XIST activator acts_upstream_of
acts_upstream_of_or_within		 ISO MGI:4887255 (PMID:21029862)
MGI:1342291|MGI:1926128 (PMID:21029862), (PMID:24613346)		 RGD PMID:21029862 PMID:24613346 NCBI chr  X:68,511,491...68,665,132 JBrowse link
G Pcgf3 polycomb group ring finger 3 involved_in ISO (MGI:5908473|PMID:28596365) RGD PMID:28596365 MGI:5908473 NCBI chr14:1,237,594...1,291,717
Ensembl chr14:1,233,947...1,291,793 		JBrowse link
G Pcgf5 polycomb group ring finger 5 involved_in ISO (MGI:5908473|PMID:28596365) RGD PMID:28596365 MGI:5908473 NCBI chr 1:234,063,854...234,180,022
Ensembl chr 1:234,063,892...234,175,315 		JBrowse link
G Rlim ring finger protein, LIM domain interacting involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:19945382)
MGI:1926128|MGI:2180008 (PMID:24613346)
GO_REF:0000033
(MGI:4418586|PMID:19945382)		 RGD
GO_Central		 PMID:19945382 PMID:24613346 GO_REF:0000033 MGI:4418586 NCBI chr  X:68,983,259...69,004,368
Ensembl chr  X:68,988,375...69,004,271 		JBrowse link
G Suz12 SUZ12 polycomb repressive complex 2 subunit acts_upstream_of_or_within ISO (PMID:27892467) RGD PMID:27892467 NCBI chr10:64,967,035...65,012,916
Ensembl chr10:64,966,967...65,012,738 		JBrowse link
G Xist X inactive specific transcript involved_in
acts_upstream_of_or_within		 ISO (PMID:9335338)
MGI:104537 (PMID:12419249), (PMID:27892467)		 RGD PMID:9335338 PMID:12419249 PMID:27892467 NCBI chr  X:68,474,987...68,492,500 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19692
    metabolic process 11455
      macromolecule metabolic process 9273
        macromolecule biosynthetic process 7210
          gene expression 6770
            regulation of gene expression 5020
              epigenetic regulation of gene expression 293
                sex-chromosome dosage compensation 20
                  dosage compensation by inactivation of X chromosome 18
                    inactivation of paternal X chromosome by genomic imprinting 3
                    random inactivation of X chromosome 10
Path 2
Term Annotations click to browse term
  biological_process 19692
    biological regulation 13305
      regulation of biological process 12902
        regulation of metabolic process 6432
          regulation of biosynthetic process 5325
            regulation of cellular biosynthetic process 5234
              regulation of macromolecule biosynthetic process 5135
                regulation of gene expression 5020
                  negative regulation of gene expression 1366
                    negative regulation of gene expression, epigenetic 184
                      heterochromatin formation 154
                        dosage compensation by inactivation of X chromosome 18
                          inactivation of paternal X chromosome by genomic imprinting 3
                          random inactivation of X chromosome 10
paths to the root