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ONTOLOGY REPORT - ANNOTATIONS

Term:lactation
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Accession:GO:0007595 term browser browse the term
Definition:The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.
Synonyms:exact_synonym: milk secretion
 xref: Wikipedia:Lactation
 only_in_taxon: NCBITaxon:40674 ! Mammalia


show annotations for term's descendants           Sort by:
lactation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 ISO RGD PMID:19702690 RGD:2315565 NCBI chr 7:79,497,536...79,706,277
Ensembl chr 7:93,147,950...93,243,238 		JBrowse link
G ALAS2 5'-aminolevulinate synthase 2 ISO RGD PMID:18255020 RGD:4144779 NCBI chr  X:47,219,588...47,241,592
Ensembl chr  X:55,451,794...55,473,680 		JBrowse link
G APRT adenine phosphoribosyltransferase ISO RGD PMID:2451510 RGD:1599204 NCBI chr16:69,522,628...69,525,138
Ensembl chr16:89,179,020...89,181,504 		JBrowse link
G ATP2B2 ATPase plasma membrane Ca2+ transporting 2 acts_upstream_of_or_within ISO (PMID:15302868) MGI PMID:15302868 NCBI chr 3:10,260,556...10,643,346
Ensembl chr 3:10,611,619...10,738,006 		JBrowse link
G ATP7A ATPase copper transporting alpha ISO RGD PMID:16741141 RGD:1599391 NCBI chr  X:67,093,675...67,231,318
Ensembl chr  X:77,255,312...77,342,756 		JBrowse link
G ATP7B ATPase copper transporting beta acts_upstream_of_or_within ISO (PMID:1588441), (PMID:6863890) RGD
MGI		 PMID:1588441 PMID:6863890 PMID:16741141 PMID:28089327 MGI:71982 RGD:1599391 RGD:25671605 NCBI chr13:33,063,698...33,144,528
Ensembl chr13:51,810,555...51,851,839 		JBrowse link
G BCAT2 branched chain amino acid transaminase 2 ISO RGD PMID:11171603 PMID:11787736 RGD:1599445 RGD:62398 NCBI chr19:45,793,433...45,809,546
Ensembl chr19:54,945,157...54,962,887 		JBrowse link
G CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase ISO RGD PMID:1476792 RGD:5132591 NCBI chr2A:27,218,699...27,245,156
Ensembl chr2A:27,306,527...27,332,804 		JBrowse link
G CAV1 caveolin 1 involved_in
acts_upstream_of_negative_effect		 IEA
ISO		 (PMID:12388746) Ensembl
MGI		 PMID:12388746 GO_REF:0000107 NCBI chr 7:108,497,125...108,533,090
Ensembl chr 7:121,193,424...121,229,655 		JBrowse link
G CCND1 cyclin D1 acts_upstream_of_or_within ISO (PMID:10419681)
(PMID:11747812)		 MGI PMID:10419681 PMID:11747812 NCBI chr11:64,737,006...64,750,353 JBrowse link
G CDO1 cysteine dioxygenase type 1 ISO RGD PMID:6509133 RGD:2301364 NCBI chr 5:111,159,041...111,170,965
Ensembl chr 5:116,955,295...116,967,506 		JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex acts_upstream_of_or_within ISO (PMID:11747812) MGI PMID:11747812 NCBI chr10:96,794,228...96,835,449
Ensembl chr10:100,280,490...100,316,918 		JBrowse link
G CP ceruloplasmin ISO RGD PMID:28089327 RGD:25671605 NCBI chr 3:146,180,527...146,239,833
Ensembl chr 3:153,764,830...153,817,544 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16141355) Ensembl
MGI		 PMID:16141355 GO_REF:0000107 NCBI chr2B:94,762,796...94,836,304
Ensembl chr2B:212,891,261...212,958,130 		JBrowse link
G CSN2 casein beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:54,276,495...54,282,221
Ensembl chr 4:60,613,091...60,618,815 		JBrowse link
G CSN3 casein kappa involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16698927) Ensembl
MGI
TreeGrafter		 PMID:16698927 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:53,972,361...53,981,203
Ensembl chr 4:60,315,922...60,324,767 		JBrowse link
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 ISO RGD PMID:8333523 RGD:2307320 NCBI chr12:31,158,814...31,164,462
Ensembl chr12:31,419,773...31,424,822 		JBrowse link
G DHODH dihydroorotate dehydrogenase (quinone) ISO RGD PMID:1476792 RGD:5132591 NCBI chr16:52,977,879...52,994,496
Ensembl chr16:71,854,238...71,870,673 		JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 acts_upstream_of_or_within ISO (PMID:18852460) MGI PMID:18852460 NCBI chr2A:87,688,732...87,759,580
Ensembl chr2A:89,596,833...89,667,468 		JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:98,625,630...99,795,371
Ensembl chr2B:217,069,644...218,272,006 		JBrowse link
G FOXB1 forkhead box B1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:38,979,727...38,983,040
Ensembl chr15:57,284,077...57,285,054 		JBrowse link
G GC GC vitamin D binding protein ISO RGD PMID:217634 RGD:2315536 NCBI chr 4:52,431,196...52,473,762
Ensembl chr 4:58,729,236...58,792,073 		JBrowse link
G GHRHR growth hormone releasing hormone receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:1270792), (PMID:2980124) Ensembl
MGI		 PMID:1270792 PMID:2980124 GO_REF:0000107 NCBI chr 7:31,582,134...31,592,914
Ensembl chr 7:31,696,914...31,712,200 		JBrowse link
G GOT2 glutamic-oxaloacetic transaminase 2 ISO RGD PMID:28798692 RGD:13504863 NCBI chr16:38,995,770...39,022,750
Ensembl chr16:58,120,781...58,147,378 		JBrowse link
G GPAT4 glycerol-3-phosphate acyltransferase 4 acts_upstream_of_or_within ISO (PMID:16449762) MGI PMID:16449762 NCBI chr 8:40,822,736...40,869,744
Ensembl chr 8:38,271,808...38,318,587 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12620994) Ensembl
MGI		 PMID:12620994 GO_REF:0000107 NCBI chr14:42,295,691...42,348,478
Ensembl chr14:60,552,374...60,604,885 		JBrowse link
G HK2 hexokinase 2 ISO RGD PMID:10562464 RGD:1624366 NCBI chr2A:74,897,914...74,957,234
Ensembl chr2A:76,400,240...76,460,874 		JBrowse link
G KALRN kalirin RhoGEF kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23116210) Ensembl
MGI		 PMID:23116210 GO_REF:0000107 NCBI chr 3:121,138,136...121,828,723
Ensembl chr 3:128,225,413...128,720,441 		JBrowse link
G LOC100987557 metaxin-1 ISO RGD PMID:19702690 RGD:2315565 NCBI chr 1:130,553,631...130,558,744 JBrowse link
G LOC100988550 signal transducer and activator of transcription 5A acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:9630227)
(PMID:11706048)		 RGD
MGI
UniProt		 PMID:7519723 PMID:8584036 PMID:9630227 PMID:11706048 GO_REF:0000043 RGD:151665740 RGD:730121 NCBI chr17:15,005,025...15,029,110
Ensembl chr17:15,228,465...15,251,783 		JBrowse link
G LOC100989105 signal transducer and activator of transcription 5B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11706048), (PMID:9630227) Ensembl
MGI		 PMID:9630227 PMID:11706048 GO_REF:0000107 NCBI chr17:15,040,303...15,116,682
Ensembl chr17:15,306,418...15,336,463 		JBrowse link
G MED1 mediator complex subunit 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15647257) Ensembl
MGI		 PMID:15647257 GO_REF:0000107 NCBI chr17:17,836,350...17,883,610
Ensembl chr17:18,050,474...18,095,118 		JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase ISO RGD PMID:7628535 RGD:729001 NCBI chr 7:108,646,278...108,772,238
Ensembl chr 7:121,365,438...121,468,159 		JBrowse link
G MUC4 mucin 4, cell surface associated ISO RGD PMID:15499570 RGD:1582108 NCBI chr 3:193,050,895...193,114,931 JBrowse link
G NCOA1 nuclear receptor coactivator 1 ISO RGD PMID:15946693 RGD:5688303 NCBI chr2A:24,485,068...24,764,135
Ensembl chr2A:24,733,117...24,859,488 		JBrowse link
G NCOR1 nuclear receptor corepressor 1 ISO RGD PMID:15946693 RGD:5688303 NCBI chr17:34,934,452...35,121,195 JBrowse link
G NCOR2 nuclear receptor corepressor 2 ISO RGD PMID:15946693 RGD:5688303 NCBI chr12:121,913,368...122,155,031
Ensembl chr12:126,201,779...126,372,745 		JBrowse link
G NEURL1 neuralized E3 ubiquitin protein ligase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11585928) Ensembl
MGI		 PMID:11585928 GO_REF:0000107 NCBI chr10:100,093,614...100,192,485 JBrowse link
G NME1 NME/NM23 nucleoside diphosphate kinase 1 acts_upstream_of_or_within ISO (PMID:12848338) MGI PMID:12848338 NCBI chr17:45,243,588...45,252,135
Ensembl chr17:50,113,622...50,131,636 		JBrowse link
G PAM peptidylglycine alpha-amidating monooxygenase ISO RGD PMID:16448835 RGD:2302418 NCBI chr 5:98,104,058...98,385,157
Ensembl chr 5:103,913,456...104,085,774 		JBrowse link
G PMCH pro-melanin concentrating hormone ISO RGD PMID:14962080 RGD:1642485 NCBI chr12:99,783,925...99,785,292
Ensembl chr12:103,181,497...103,182,616 		JBrowse link
G PPAT phosphoribosyl pyrophosphate amidotransferase ISO RGD PMID:2451510 RGD:1599204 NCBI chr 4:67,491,407...67,533,822
Ensembl chr 4:74,059,966...74,102,002 		JBrowse link
G PRL prolactin involved_in IEA UniProt GO_REF:0000043 NCBI chr 6:22,109,974...22,125,433
Ensembl chr 6:22,450,132...22,459,829 		JBrowse link
G PRLR prolactin receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11445538)
(PMID:11706048), (PMID:16469767)		 Ensembl
MGI		 PMID:11445538 PMID:11706048 PMID:16469767 GO_REF:0000107 NCBI chr 5:75,139,852...75,321,695
Ensembl chr 5:80,532,058...80,600,403 		JBrowse link
G RPLP0 ribosomal protein lateral stalk subunit P0 ISO RGD PMID:20863866 RGD:11039458 NCBI chr12:117,771,887...117,776,391
Ensembl chr12:121,146,882...121,151,388 		JBrowse link
G SERPINC1 serpin family C member 1 ISO RGD PMID:22776112 RGD:11035275 NCBI chr 1:149,421,737...149,435,301
Ensembl chr 1:153,126,031...153,139,369 		JBrowse link
G SLC29A1 solute carrier family 29 member 1 (Augustine blood group) ISO RGD PMID:19702690 RGD:2315565 NCBI chr 6:43,815,006...43,830,290
Ensembl chr 6:45,099,243...45,113,689 		JBrowse link
G SLC29A2 solute carrier family 29 member 2 ISO RGD PMID:19702690 RGD:2315565 NCBI chr11:61,728,204...61,738,174
Ensembl chr11:65,054,041...65,063,540 		JBrowse link
G SLC30A4 solute carrier family 30 member 4 ISO RGD PMID:14608047 RGD:2299951 NCBI chr15:24,425,816...24,469,085
Ensembl chr15:42,758,455...42,798,815 		JBrowse link
G SLC6A3 solute carrier family 6 member 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9247269) Ensembl
MGI		 PMID:9247269 GO_REF:0000107 Ensembl chr 5:1,437,567...1,488,829 JBrowse link
G SOCS2 suppressor of cytokine signaling 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11445538) Ensembl
MGI		 PMID:11445538 GO_REF:0000107 NCBI chr12:91,115,319...91,134,191
Ensembl chr12:94,514,455...94,520,748 		JBrowse link
G UMPS uridine monophosphate synthetase ISO RGD PMID:1476792 RGD:5132591 NCBI chr 3:121,832,758...121,851,707
Ensembl chr 3:128,731,355...128,745,029 		JBrowse link
G UPRT uracil phosphoribosyltransferase homolog ISO RGD PMID:1476792 RGD:5132591 NCBI chr  X:64,524,889...64,561,439
Ensembl chr  X:74,639,179...74,675,221 		JBrowse link
G USF2 upstream transcription factor 2, c-fos interacting involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12907752) Ensembl
MGI		 PMID:12907752 GO_REF:0000107 NCBI chr19:32,215,305...32,226,172 JBrowse link
G VDR vitamin D receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15178742) Ensembl
MGI		 PMID:15178742 GO_REF:0000107 NCBI chr12:40,828,413...40,891,700
Ensembl chr12:41,702,742...41,766,192 		JBrowse link
G VEGFA vascular endothelial growth factor A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17625068) Ensembl
MGI		 PMID:17625068 GO_REF:0000107 NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353 		JBrowse link
G XDH xanthine dehydrogenase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12502743) Ensembl
MGI		 PMID:12502743 GO_REF:0000107 NCBI chr2A:31,356,011...31,435,111
Ensembl chr2A:31,425,183...31,504,455 		JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:130,350,798...130,366,690
Ensembl chr 1:133,959,847...133,975,729 		JBrowse link
milk ejection reflex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 acts_upstream_of_or_within ISO (PMID:20089884) MGI PMID:20089884 NCBI chr 6:119,213,513...119,227,617 JBrowse link
positive regulation of lactation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase ISO RGD PMID:648869 RGD:11557979 (All species) (All species) NCBI chr22:2,704,015...2,731,326
Ensembl chr22:18,375,434...18,402,387 		JBrowse link
G PRL prolactin involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:22,109,974...22,125,433
Ensembl chr 6:22,450,132...22,459,829 		JBrowse link
G XBP1 X-box binding protein 1 involved_in ISO (MGI:5496939|PMID:23623498) UniProt PMID:23623498 MGI:5496939 NCBI chr22:9,863,479...9,869,491
Ensembl chr22:27,567,041...27,571,943 		JBrowse link
regulation of lactation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G OAS2 2'-5'-oligoadenylate synthetase 2 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr12:113,968,061...114,001,209 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16447
    biological regulation 11461
      regulation of biological quality 3120
        regulation of body fluid levels 376
          body fluid secretion 128
            lactation 62
              milk ejection reflex 1
              negative regulation of lactation 0
              positive regulation of lactation + 3
              regulation of lactation + 4
Path 2
Term Annotations click to browse term
  biological_process 16447
    localization 5286
      establishment of localization 4586
        transport 4276
          secretion 1116
            body fluid secretion 128
              lactation 62
                milk ejection reflex 1
                negative regulation of lactation 0
                positive regulation of lactation + 3
                regulation of lactation + 4
paths to the root