APRT (adenine phosphoribosyltransferase) - Rat Genome Database

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Gene: APRT (adenine phosphoribosyltransferase) Pan paniscus
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Symbol: APRT
Name: adenine phosphoribosyltransferase
RGD ID: 11732431
Description: ENCODES a protein that exhibits AMP binding (ortholog); INVOLVED IN adenine metabolic process (ortholog); AMP salvage (ortholog); cellular response to insulin stimulus (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH 16Q24.3 Microdeletion Syndrome (ortholog); adenine phosphoribosyltransferase deficiency (ortholog); autosomal recessive chronic granulomatous disease 4 (ortholog); FOUND IN cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21898,582,498 - 98,585,192 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan116104,494,670 - 104,497,177 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01669,522,628 - 69,525,138 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11689,179,020 - 89,181,505 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1689,179,020 - 89,181,504 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA,ISO)
nucleoplasm  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
APRT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21898,582,498 - 98,585,192 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan116104,494,670 - 104,497,177 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01669,522,628 - 69,525,138 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11689,179,020 - 89,181,505 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1689,179,020 - 89,181,504 (-)Ensemblpanpan1.1panPan2
APRT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381688,809,339 - 88,811,928 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1688,809,339 - 88,811,937 (-)EnsemblGRCh38hg38GRCh38
GRCh371688,875,747 - 88,878,336 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361687,403,378 - 87,405,843 (-)NCBINCBI36Build 36hg18NCBI36
Build 341687,403,379 - 87,405,879NCBI
Celera1673,944,514 - 73,946,979 (-)NCBICelera
Cytogenetic Map16q24.3NCBI
HuRef1674,573,103 - 74,575,568 (-)NCBIHuRef
CHM1_11690,287,144 - 90,289,609 (-)NCBICHM1_1
T2T-CHM13v2.01694,879,859 - 94,882,448 (-)NCBIT2T-CHM13v2.0
Aprt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398123,301,376 - 123,303,646 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8123,301,374 - 123,303,648 (-)EnsemblGRCm39 Ensembl
GRCm388122,574,637 - 122,576,907 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8122,574,635 - 122,576,909 (-)EnsemblGRCm38mm10GRCm38
MGSCv378125,098,537 - 125,100,807 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368125,460,727 - 125,462,950 (-)NCBIMGSCv36mm8
Celera8126,804,235 - 126,806,505 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map871.91NCBI
Aprt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81967,534,737 - 67,537,027 (-)NCBIGRCr8
mRatBN7.21950,626,201 - 50,628,491 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1950,626,202 - 50,628,431 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1957,421,206 - 57,423,174 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01958,101,358 - 58,103,326 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01960,319,830 - 60,321,798 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01955,387,288 - 55,389,256 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1955,387,288 - 55,389,256 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01966,095,804 - 66,097,772 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41952,854,657 - 52,856,625 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11952,859,538 - 52,861,506 (-)NCBI
Celera1949,865,842 - 49,867,810 (-)NCBICelera
Cytogenetic Map19q12NCBI
Aprt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555412,687,938 - 2,690,906 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555412,687,938 - 2,690,906 (-)NCBIChiLan1.0ChiLan1.0
APRT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1564,563,154 - 64,565,537 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl564,563,192 - 64,565,445 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha564,574,619 - 64,577,004 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0564,783,377 - 64,785,760 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl564,783,416 - 64,785,668 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1564,809,556 - 64,811,939 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0564,641,062 - 64,643,445 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0565,047,101 - 65,049,491 (+)NCBIUU_Cfam_GSD_1.0
Aprt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934925,160,104 - 25,162,762 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936641913,475 - 918,748 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936641913,674 - 916,312 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APRT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6890,831 - 893,276 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16890,272 - 893,278 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.261,090,009 - 1,092,413 (-)NCBISscrofa10.2Sscrofa10.2susScr3
APRT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1574,196,858 - 74,199,789 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl574,194,013 - 74,199,891 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660471,479,268 - 1,482,118 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aprt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624746805,758 - 807,963 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624746805,742 - 807,963 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000006468   ⟹   ENSPPAP00000001351
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1689,179,020 - 89,181,504 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000006520   ⟹   ENSPPAP00000001357
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1689,179,249 - 89,181,449 (-)Ensembl
RefSeq Acc Id: XM_003805767   ⟹   XP_003805815
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21898,582,498 - 98,585,192 (-)NCBI
NHGRI_mPanPan116104,494,670 - 104,497,177 (-)NCBI
Mhudiblu_PPA_v01669,522,628 - 69,525,138 (-)NCBI
PanPan1.11689,179,020 - 89,181,505 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008974681   ⟹   XP_008972929
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21898,582,498 - 98,585,005 (-)NCBI
NHGRI_mPanPan116104,494,670 - 104,497,177 (-)NCBI
Mhudiblu_PPA_v01669,522,628 - 69,525,138 (-)NCBI
PanPan1.11689,179,020 - 89,181,505 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008974685   ⟹   XP_008972933
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21898,582,498 - 98,585,005 (-)NCBI
NHGRI_mPanPan116104,494,670 - 104,497,177 (-)NCBI
Mhudiblu_PPA_v01669,522,628 - 69,525,138 (-)NCBI
PanPan1.11689,179,020 - 89,181,505 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003805815 (Get FASTA)   NCBI Sequence Viewer  
  XP_008972929 (Get FASTA)   NCBI Sequence Viewer  
  XP_008972933 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000001351.1
  ENSPPAP00000001357.1
RefSeq Acc Id: XP_008972929   ⟸   XM_008974681
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008972933   ⟸   XM_008974685
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_003805815   ⟸   XM_003805767
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSPPAP00000001351   ⟸   ENSPPAT00000006468
RefSeq Acc Id: ENSPPAP00000001357   ⟸   ENSPPAT00000006520
Protein Domains
Phosphoribosyltransferase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000005769 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000006468.1 UniProtKB/TrEMBL
  ENSPPAT00000006520.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.2020 UniProtKB/TrEMBL
InterPro Ade_phspho_trans UniProtKB/TrEMBL
  PRibTrfase_dom UniProtKB/TrEMBL
  PRTase-like UniProtKB/TrEMBL
KEGG Report pps:100990412 UniProtKB/TrEMBL
NCBI Gene APRT ENTREZGENE
PANTHER ADENINE PHOSPHORIBOSYLTRANSFERASE UniProtKB/TrEMBL
  ADENINE PHOSPHORIBOSYLTRANSFERASE UniProtKB/TrEMBL
Pfam Pribosyltran UniProtKB/TrEMBL
Superfamily-SCOP SSF53271 UniProtKB/TrEMBL
UniProt A0A2R8ZCU3_PANPA UniProtKB/TrEMBL
  A0A2R8ZFF4_PANPA UniProtKB/TrEMBL