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ONTOLOGY REPORT - ANNOTATIONS

Term:glutathione biosynthetic process
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Accession:GO:0006750 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.
Synonyms:exact_synonym: glutathione anabolism;   glutathione biosynthesis;   glutathione formation;   glutathione synthesis
 xref: MetaCyc:GLUTATHIONESYN-PWY


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glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclc glutamate-cysteine ligase, catalytic subunit acts_upstream_of_or_within
involved_in		 IMP
ISO
IBA
IEA
ISS		 MGI:2387010 (PMID:10805773), (PMID:16081425)
GO_REF:0000033
GO_REF:0000041
(PMID:10395918), (PMID:12663448), (PMID:8104187), (PMID:9675072)
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:8104187 PMID:9675072 PMID:10395918 PMID:10805773 PMID:12663448 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000041, RGD:1582661 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit acts_upstream_of_or_within
involved_in		 IMP
ISO
IBA
IEA
ISS		 (PMID:16081425)
GO_REF:0000033
GO_REF:0000041
(PMID:10395918), (PMID:12081989), (PMID:9675072)
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:9675072 PMID:10395918 PMID:12081989 PMID:16081425 PMID:16183645 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041, RGD:1582661 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 involved_in ISO
IEA		 (MGI:5294309|PMID:12468440)
GO_REF:0000107		 RGD
Ensembl		 PMID:12468440 GO_REF:0000107 MGI:5294309 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Ggt5 gamma-glutamyltransferase 5 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:13,043,255...13,071,523
Ensembl chr20:13,043,257...13,071,450 		JBrowse link
G Ggt6 gamma-glutamyl transferase 6 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr10:57,051,977...57,054,900
Ensembl chr10:57,051,825...57,067,260 		JBrowse link
G Ggt7 gamma-glutamyltransferase 7 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:143,978,073...144,004,597
Ensembl chr 3:143,978,082...144,001,492 		JBrowse link
G Gss glutathione synthetase involved_in
acts_upstream_of_or_within		 IDA
IEA
ISO		 GO_REF:0000041
(MGI:81780|PMID:8660701)		 UniProt
RGD		 PMID:8660701 PMID:10964706 GO_REF:0000041 MGI:81780, RGD:1599340 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198 		JBrowse link
G Hagh hydroxyacyl glutathione hydrolase involved_in IEA
ISO		 GO_REF:0000107
(PMID:8550579)		 Ensembl
RGD		 PMID:8550579 GO_REF:0000107 NCBI chr10:13,874,883...13,889,527
Ensembl chr10:13,875,241...13,889,504 		JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 involved_in ISO (PMID:8703034) RGD PMID:8703034 NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828 		JBrowse link
G Slc1a1 solute carrier family 1 member 1 involved_in ISO (PMID:12614333) RGD PMID:12614333 NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402 		JBrowse link
G Slc1a2 solute carrier family 1 member 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:12614333)		 Ensembl
RGD		 PMID:12614333 GO_REF:0000107 NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498 		JBrowse link
positive regulation of glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (MGI:5616326|PMID:14978030) RGD PMID:14978030 MGI:5616326 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 involved_in ISO (MGI:5616326|PMID:14978030) RGD PMID:14978030 MGI:5616326 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
regulation of glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc7a11 solute carrier family 7 member 11 acts_upstream_of_or_within ISO MGI:1857061 (PMID:16037214) RGD PMID:16037214 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19694
    metabolic process 11456
      biosynthetic process 8173
        amide biosynthetic process 142
          glutathione biosynthetic process 14
            negative regulation of glutathione biosynthetic process 0
            positive regulation of glutathione biosynthetic process 2
            regulation of glutathione biosynthetic process + 3
Path 2
Term Annotations click to browse term
  biological_process 19694
    metabolic process 11456
      biosynthetic process 8173
        organic substance biosynthetic process 8108
          organonitrogen compound biosynthetic process 2088
            cellular modified amino acid biosynthetic process 41
              glutathione biosynthetic process 14
                negative regulation of glutathione biosynthetic process 0
                positive regulation of glutathione biosynthetic process 2
                regulation of glutathione biosynthetic process + 3
paths to the root