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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA replication initiation
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Accession:GO:0006270 term browser browse the term
Definition:The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding.
Synonyms:exact_synonym: DNA-dependent DNA replication initiation
 narrow_synonym: DNA endoreduplication initiation;   DNA re-replication initiation
 alt_id: GO:0042024


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DNA replication initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNE1 cyclin E1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12941272) Ensembl
MGI		 PMID:12941272 GO_REF:0000107 NCBI chr19:26,739,285...26,751,630
Ensembl chr19:35,496,700...35,510,295 		JBrowse link
G CCNE2 cyclin E2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12941272) Ensembl
MGI		 PMID:12941272 GO_REF:0000107 NCBI chr 8:91,499,647...91,518,488
Ensembl chr 8:93,702,104...93,717,151 		JBrowse link
G CDC45 cell division cycle 45 involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr22:2,239,040...2,279,807
Ensembl chr22:17,913,729...17,955,195 		JBrowse link
G CDC6 cell division cycle 6 involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000104 NCBI chr17:16,987,721...17,002,488
Ensembl chr17:17,211,681...17,225,972 		JBrowse link
G MCM10 minichromosome maintenance 10 replication initiation factor involved_in IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr10:13,165,811...13,215,024
Ensembl chr10:13,138,824...13,187,991 		JBrowse link
G MCM2 minichromosome maintenance complex component 2 involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr 3:124,643,362...124,667,121
Ensembl chr 3:131,950,887...131,974,641 		JBrowse link
G MCM3 minichromosome maintenance complex component 3 involved_in IEA InterPro GO_REF:0000002 NCBI chr 6:51,816,615...51,837,404
Ensembl chr 6:53,085,231...53,105,344 		JBrowse link
G MCM4 minichromosome maintenance complex component 4 involved_in IEA InterPro GO_REF:0000002 NCBI chr 8:44,387,529...44,404,773
Ensembl chr 8:41,778,247...41,794,783 		JBrowse link
G MCM5 minichromosome maintenance complex component 5 involved_in IEA UniProt
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 NCBI chr22:16,407,145...16,431,822
Ensembl chr22:34,249,831...34,274,423 		JBrowse link
G MCM6 minichromosome maintenance complex component 6 involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000104 NCBI chr2B:23,986,278...24,023,045
Ensembl chr2B:139,911,909...139,947,687 		JBrowse link
G MCM7 minichromosome maintenance complex component 7 involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 7:92,128,037...92,136,976
Ensembl chr 7:105,561,591...105,570,720 		JBrowse link
G NOC3L NOC3 like DNA replication regulator involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr10:91,052,341...91,101,068
Ensembl chr10:94,579,840...94,609,405 		JBrowse link
G ORC1 origin recognition complex subunit 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:51,630,344...51,666,327
Ensembl chr 1:53,238,377...53,273,653 		JBrowse link
G ORC2 origin recognition complex subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:88,166,351...88,221,618
Ensembl chr2B:206,325,661...206,380,647 		JBrowse link
G ORC3 origin recognition complex subunit 3 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:85,466,928...85,552,619
Ensembl chr 6:88,741,362...88,829,801 		JBrowse link
G ORC4 origin recognition complex subunit 4 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr2B:11,841,808...11,931,620
Ensembl chr2B:152,292,822...152,379,487 		JBrowse link
G ORC5 origin recognition complex subunit 5 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:96,118,272...96,197,216
Ensembl chr 7:108,861,281...108,939,389 		JBrowse link
G ORC6 origin recognition complex subunit 6 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr16:26,954,596...26,962,780
Ensembl chr16:45,846,747...45,854,836 		JBrowse link
G POLA1 DNA polymerase alpha 1, catalytic subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:17,290,805...17,592,163
Ensembl chr  X:24,657,878...24,960,231 		JBrowse link
G POLA2 DNA polymerase alpha 2, accessory subunit involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr11:60,626,555...60,670,716
Ensembl chr11:63,966,531...64,001,335 		JBrowse link
G PRIM1 DNA primase subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:32,155,541...32,176,363
Ensembl chr12:32,408,929...32,428,734 		JBrowse link
G PRIM2 DNA primase subunit 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:56,875,331...56,884,118 JBrowse link
G TOPBP1 DNA topoisomerase II binding protein 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 3:130,667,998...130,729,569
Ensembl chr 3:138,143,893...138,203,363 		JBrowse link
mitotic DNA replication initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GINS3 GINS complex subunit 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr16:38,653,876...38,672,154
Ensembl chr16:57,790,392...57,801,904 		JBrowse link
G MCM2 minichromosome maintenance complex component 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 3:124,643,362...124,667,121
Ensembl chr 3:131,950,887...131,974,641 		JBrowse link
G MCM3 minichromosome maintenance complex component 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:51,816,615...51,837,404
Ensembl chr 6:53,085,231...53,105,344 		JBrowse link
G MCM4 minichromosome maintenance complex component 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 8:44,387,529...44,404,773
Ensembl chr 8:41,778,247...41,794,783 		JBrowse link
G POLA1 DNA polymerase alpha 1, catalytic subunit involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr  X:17,290,805...17,592,163
Ensembl chr  X:24,657,878...24,960,231 		JBrowse link
positive regulation of DNA-templated DNA replication initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDK2 cyclin dependent kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20215406) Ensembl
MGI		 PMID:20215406 GO_REF:0000107 NCBI chr12:32,940,225...32,946,236
Ensembl chr12:33,189,934...33,195,945 		JBrowse link
G CIZ1 CDKN1A interacting zinc finger protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15585571)
(PMID:20215406)		 Ensembl
MGI		 PMID:15585571 PMID:20215406 GO_REF:0000107 NCBI chr 9:99,282,821...99,325,404
Ensembl chr 9:127,956,915...127,982,449 		JBrowse link
regulation of DNA-templated DNA replication initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDT1 chromatin licensing and DNA replication factor 1 involved_in IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr16:69,516,728...69,522,419
Ensembl chr16:89,174,071...89,177,823 		JBrowse link
G GMNN geminin DNA replication inhibitor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:24,612,864...24,624,010
Ensembl chr 6:24,944,377...24,955,575 		JBrowse link
G KAT7 lysine acetyltransferase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:43,875,921...43,916,352
Ensembl chr17:48,605,488...48,645,784 		JBrowse link
G MCIDAS multiciliate differentiation and DNA synthesis associated cell cycle protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:58,802,664...58,811,075
Ensembl chr 5:60,425,341...60,433,035 		JBrowse link
G TICRR TOPBP1 interacting checkpoint and replication regulator involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr15:68,270,029...68,322,201
Ensembl chr15:87,476,738...87,528,870 		JBrowse link
G WRNIP1 WRN helicase interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:2,587,170...2,608,179
Ensembl chr 6:2,691,235...2,711,062 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16447
    metabolic process 10323
      primary metabolic process 8935
        nucleobase-containing compound metabolic process 5105
          nucleic acid metabolic process 4608
            DNA metabolic process 904
              DNA replication initiation 32
                cell cycle DNA replication initiation + 5
                negative regulation of DNA-templated DNA replication initiation + 0
                positive regulation of DNA-templated DNA replication initiation + 2
                regulation of DNA-templated DNA replication initiation + 8
Path 2
Term Annotations click to browse term
  biological_process 16447
    metabolic process 10323
      organic substance metabolic process 9890
        organic cyclic compound metabolic process 5563
          nucleobase-containing compound metabolic process 5105
            nucleic acid metabolic process 4608
              DNA metabolic process 904
                DNA replication 265
                  DNA-templated DNA replication 155
                    DNA replication initiation 32
                      cell cycle DNA replication initiation + 5
                      negative regulation of DNA-templated DNA replication initiation + 0
                      positive regulation of DNA-templated DNA replication initiation + 2
                      regulation of DNA-templated DNA replication initiation + 8
paths to the root