Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:extracellularly ATP-gated monoatomic cation channel activity
go back to main search page
Accession:GO:0004931 term browser browse the term
Definition:Enables the transmembrane transfer of a monoatomic cation by a channel that opens when ATP is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
Comment:Note that this term refers to an activity and not a gene product. Consider also annotating to the molecular function term 'purinergic nucleotide receptor activity ; GO:0001614'.
Synonyms:broad_synonym: extracellularly ATP-gated cation channel activity;   purinoceptor;   purinoreceptor
 related_synonym: P2X receptor
 xref: reactome:R-HSA-877187 "P2X7 mediates loss of intracellular K+"


show annotations for term's descendants           Sort by:
extracellularly ATP-gated monoatomic cation channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2RX1 purinergic receptor P2X 1 enables ISO
IEA		 RGD
TreeGrafter
UniProt
InterPro		 PMID:16934235 GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 RGD:1642659 NCBI chr17:3,944,636...3,965,260
Ensembl chr17:3,935,982...3,956,595 		JBrowse link
G P2RX2 purinergic receptor P2X 2 enables ISO
IEA		 RGD
TreeGrafter
Ensembl
UniProt
InterPro		 PMID:15317863 PMID:16190872 PMID:16857707 PMID:16934235 PMID:17517890 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 RGD:1642653 RGD:1642659 RGD:1642661 RGD:1642665 RGD:1642666 NCBI chr12:129,969,793...129,974,399 JBrowse link
G P2RX3 purinergic receptor P2X 3 enables ISO
IEA		 RGD
TreeGrafter
UniProt
Ensembl
InterPro		 PMID:12581826 PMID:16934235 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 RGD:1642659 RGD:1642675 NCBI chr11:52,579,190...52,614,329
Ensembl chr 3:160,070,875...160,106,120 		JBrowse link
G P2RX4 purinergic receptor P2X 4 enables ISO
IEA		 PMID:12819199 RGD
TreeGrafter
UniProt
InterPro
Ensembl		 PMID:12819199 PMID:16934235 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 RGD:1642659 RGD:1642695 NCBI chr12:118,807,961...118,832,267
Ensembl chr12:122,178,672...122,202,959 		JBrowse link
G P2RX5 purinergic receptor P2X 5 enables ISO
IEA		 RGD
TreeGrafter
InterPro
Ensembl
UniProt		 PMID:12135987 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 RGD:729229 NCBI chr17:3,722,117...3,745,833
Ensembl chr17:3,719,457...3,739,709 		JBrowse link
G P2RX6 purinergic receptor P2X 6 enables ISO
IEA		 RGD
TreeGrafter
UniProt
InterPro		 PMID:8786426 GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 RGD:729425 NCBI chr22:3,239,019...3,251,966
Ensembl chr22:19,728,644...19,741,078 		JBrowse link
G P2RX7 purinergic receptor P2X 7 enables ISO
IEA		 RGD
Ensembl
InterPro
TreeGrafter		 PMID:17394459 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:1642698 NCBI chr12:118,731,761...118,786,039
Ensembl chr12:122,102,888...122,154,068 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17494
    transporter activity 1158
      transmembrane transporter activity 1070
        monoatomic ion transmembrane transporter activity 716
          monoatomic ion channel activity 438
            monoatomic cation channel activity 334
              ligand-gated monoatomic cation channel activity 132
                extracellularly ATP-gated monoatomic cation channel activity 7
Path 2
Term Annotations click to browse term
  molecular_function 17494
    transporter activity 1158
      transmembrane transporter activity 1070
        passive transmembrane transporter activity 497
          channel activity 497
            gated channel activity 320
              ligand-gated channel activity 189
                ligand-gated monoatomic ion channel activity 185
                  extracellular ligand-gated monoatomic ion channel activity 74
                    excitatory extracellular ligand-gated monoatomic ion channel activity 42
                      extracellularly ATP-gated monoatomic cation channel activity 7
paths to the root