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ONTOLOGY REPORT - ANNOTATIONS

Term:G protein activity
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Accession:GO:0003925 term browser browse the term
Definition:A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP).
Synonyms:exact_synonym: signaling G protein activity
 narrow_synonym: Ras superfamily protein;   heterotrimeric G-protein GTPase activity;   large G-protein GTPase activity;   large G-protein activity;   small G-protein;   small GTPase;   small GTPase activity;   small monomeric G protein activity;   small monomeric GTPase activity
 alt_id: GO:0003927


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G protein activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arf1 ADP-ribosylation factor 1 enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr11:59,102,237...59,119,042
Ensembl chr11:59,102,238...59,119,096 		JBrowse link
G Arf6 ADP-ribosylation factor 6 enables ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr12:69,418,924...69,422,754
Ensembl chr12:69,418,924...69,420,557 		JBrowse link
G Arl8b ADP-ribosylation factor-like 8B enables ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 6:108,760,020...108,800,684
Ensembl chr 6:108,760,060...108,802,239 		JBrowse link
G Cdc42 cell division cycle 42 enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr 4:137,047,011...137,085,007
Ensembl chr 4:137,047,007...137,085,031 		JBrowse link
G Eras ES cell-expressed Ras enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr  X:7,790,515...7,794,846
Ensembl chr  X:7,790,515...7,794,846 		JBrowse link
G Gbp2 guanylate binding protein 2 enables ISO
ISS		 (PMID:8706832) MGI PMID:8706832 GO_REF:0000119 MGI:4834177 NCBI chr 3:142,326,424...142,343,769
Ensembl chr 3:142,326,363...142,343,769 		JBrowse link
G Gbp2b guanylate binding protein 2b enables ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 3:142,300,577...142,324,940
Ensembl chr 3:142,300,608...142,324,940 		JBrowse link
G Gbp5 guanylate binding protein 5 enables ISS (PMID:20180847) UniProt PMID:20180847 NCBI chr 3:142,202,695...142,228,105
Ensembl chr 3:142,199,739...142,228,105 		JBrowse link
G Gm12250 predicted gene 12250 enables IDA (PMID:33469160) UniProt PMID:33469160 NCBI chr11:58,074,669...58,081,024
Ensembl chr11:58,078,565...58,079,838 		JBrowse link
G Gna11 guanine nucleotide binding protein, alpha 11 enables IMP
ISO		 (PMID:26075576)
(PMID:26628681)		 MGI PMID:26075576 PMID:26628681 NCBI chr10:81,364,558...81,380,996
Ensembl chr10:81,364,558...81,381,024 		JBrowse link
G Gna12 guanine nucleotide binding protein, alpha 12 enables ISO (PMID:8647866) UniProt PMID:8647866 NCBI chr 5:140,745,699...140,816,186
Ensembl chr 5:140,744,163...140,816,186 		JBrowse link
G Gna13 guanine nucleotide binding protein, alpha 13 enables ISO (PMID:10199825) UniProt PMID:10199825 NCBI chr11:109,253,620...109,292,195
Ensembl chr11:109,253,657...109,292,195 		JBrowse link
G Gnaq guanine nucleotide binding protein, alpha q polypeptide enables ISO
IMP		 (PMID:26628681)
(PMID:26075576)		 MGI PMID:26075576 PMID:26628681 NCBI chr19:16,110,048...16,365,884
Ensembl chr19:16,110,195...16,364,827 		JBrowse link
G Gnas GNAS complex locus enables IMP (PMID:12145344) MGI PMID:12145344 NCBI chr 2:174,126,113...174,188,537
Ensembl chr 2:174,126,113...174,188,537 		JBrowse link
G Hras Harvey rat sarcoma virus oncogene enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr 7:140,770,839...140,773,938
Ensembl chr 7:140,769,018...140,773,918 		JBrowse link
G Igtp interferon gamma induced GTPase enables ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:58,090,382...58,098,418
Ensembl chr11:58,090,382...58,098,417 		JBrowse link
G Irgm1 immunity-related GTPase family M member 1 enables ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:48,756,072...48,762,247
Ensembl chr11:48,752,795...48,762,510 		JBrowse link
G Irgm2 immunity-related GTPase family M member 2 enables ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:58,105,803...58,113,609
Ensembl chr11:58,090,444...58,113,608 		JBrowse link
G Kras Kirsten rat sarcoma viral oncogene homolog enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965 		JBrowse link
G Mras muscle and microspikes RAS enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr 9:99,267,473...99,319,505
Ensembl chr 9:99,267,473...99,319,434 		JBrowse link
G Nras neuroblastoma ras oncogene enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr 3:102,965,643...102,975,230
Ensembl chr 3:102,965,601...102,975,230 		JBrowse link
G Rab10 RAB10, member RAS oncogene family enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr12:3,297,428...3,359,969
Ensembl chr12:3,297,428...3,359,969 		JBrowse link
G Rab11a RAB11A, member RAS oncogene family enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr 9:64,622,582...64,645,038
Ensembl chr 9:64,622,581...64,645,040 		JBrowse link
G Rab11b RAB11B, member RAS oncogene family enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr17:33,961,458...33,979,460
Ensembl chr17:33,961,458...33,979,504 		JBrowse link
G Rab1a RAB1A, member RAS oncogene family enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr11:20,151,412...20,176,856
Ensembl chr11:20,151,432...20,176,856 		JBrowse link
G Rab1b RAB1B, member RAS oncogene family enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr19:5,149,235...5,157,024
Ensembl chr19:5,149,233...5,157,100 		JBrowse link
G Rab27a RAB27A, member RAS oncogene family enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr 9:72,952,092...73,004,905
Ensembl chr 9:72,952,136...73,004,911 		JBrowse link
G Rab27b RAB27B, member RAS oncogene family enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr18:70,112,202...70,274,704
Ensembl chr18:70,112,202...70,274,676 		JBrowse link
G Rab2a RAB2A, member RAS oncogene family enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr 4:8,535,661...8,607,708
Ensembl chr 4:8,535,644...8,607,778 		JBrowse link
G Rab2b RAB2B, member RAS oncogene family enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr14:52,499,216...52,516,852
Ensembl chr14:52,499,216...52,517,002 		JBrowse link
G Rab4a RAB4A, member RAS oncogene family enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr 8:124,532,748...124,562,030
Ensembl chr 8:124,532,724...124,562,026 		JBrowse link
G Rab4b RAB4B, member RAS oncogene family enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr 7:26,867,858...26,878,308
Ensembl chr 7:26,867,849...26,878,321 		JBrowse link
G Rab5a RAB5A, member RAS oncogene family enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr17:53,786,262...53,814,706
Ensembl chr17:53,786,262...53,814,708 		JBrowse link
G Rab5b RAB5B, member RAS oncogene family enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr10:128,511,980...128,532,160
Ensembl chr10:128,513,044...128,532,133 		JBrowse link
G Rab5c RAB5C, member RAS oncogene family enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr11:100,605,829...100,629,041
Ensembl chr11:100,605,835...100,629,041 		JBrowse link
G Rab6b RAB6B, member RAS oncogene family enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr 9:102,988,866...103,062,475
Ensembl chr 9:102,988,986...103,062,475 		JBrowse link
G Rab7 RAB7, member RAS oncogene family enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr 6:87,976,088...88,022,252
Ensembl chr 6:87,976,088...88,022,252 		JBrowse link
G Rab8a RAB8A, member RAS oncogene family enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr 8:72,915,044...72,935,210
Ensembl chr 8:72,915,044...72,937,748 		JBrowse link
G Rac1 Rac family small GTPase 1 enables IDA (PMID:35263589)
(PMID:17058265), (PMID:35676269)		 UniProt
MGI		 PMID:17058265 PMID:35263589 PMID:35676269 NCBI chr 5:143,491,236...143,513,786
Ensembl chr 5:143,489,389...143,513,791 		JBrowse link
G Rac3 Rac family small GTPase 3 enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr11:120,612,294...120,614,795
Ensembl chr11:120,612,296...120,614,795 		JBrowse link
G Rala v-ral simian leukemia viral oncogene A (ras related) enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr13:18,055,160...18,118,802
Ensembl chr13:18,055,156...18,118,824 		JBrowse link
G Ralb v-ral simian leukemia viral oncogene B enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr 1:119,398,035...119,432,512
Ensembl chr 1:119,398,035...119,432,524 		JBrowse link
G Ran RAN, member RAS oncogene family enables ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 5:129,097,264...129,101,388
Ensembl chr 5:129,097,133...129,101,387 		JBrowse link
G Rap1a RAS-related protein 1a enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr 3:105,634,576...105,708,740
Ensembl chr 3:105,634,583...105,708,652 		JBrowse link
G Rap1b RAS related protein 1b enables IDA (PMID:11056535) MGI PMID:11056535 NCBI chr10:117,650,502...117,681,879
Ensembl chr10:117,649,776...117,681,940 		JBrowse link
G Rap2a RAS related protein 2a enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr14:120,715,873...120,744,606
Ensembl chr14:120,715,856...120,744,606 		JBrowse link
G Rap2b RAP2B, member of RAS oncogene family enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr 3:61,271,928...61,276,124
Ensembl chr 3:61,269,059...61,275,851 		JBrowse link
G Rap2c RAP2C, member of RAS oncogene family enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr  X:50,093,163...50,108,966
Ensembl chr  X:50,092,789...50,106,895 		JBrowse link
G Rasl10a RAS-like, family 10, member A enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr11:5,008,128...5,010,385
Ensembl chr11:5,008,128...5,010,385 		JBrowse link
G Rasl10b RAS-like, family 10, member B enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr11:83,299,963...83,311,865
Ensembl chr11:83,299,963...83,311,865 		JBrowse link
G Rasl11a RAS-like, family 11, member A enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr 5:146,781,881...146,784,536
Ensembl chr 5:146,781,881...146,784,537 		JBrowse link
G Rasl11b RAS-like, family 11, member B enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr 5:74,355,987...74,360,138
Ensembl chr 5:74,355,947...74,360,142 		JBrowse link
G Rasl12 RAS-like, family 12 enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr 9:65,305,766...65,323,420
Ensembl chr 9:65,305,788...65,322,135 		JBrowse link
G Rerg RAS-like, estrogen-regulated, growth-inhibitor enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr 6:137,031,822...137,147,494
Ensembl chr 6:137,031,823...137,147,495 		JBrowse link
G Rergl RERG/RAS-like enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr 6:139,470,180...139,478,907
Ensembl chr 6:139,469,971...139,478,974 		JBrowse link
G Rhoa ras homolog family member A enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133 		JBrowse link
G Rit1 Ras-like without CAAX 1 enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr 3:88,624,154...88,638,354
Ensembl chr 3:88,624,145...88,638,356 		JBrowse link
G Rit2 Ras-like without CAAX 2 enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr18:31,107,367...31,450,181
Ensembl chr18:31,106,542...31,450,343 		JBrowse link
G Sar1a secretion associated Ras related GTPase 1A enables ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:61,516,096...61,529,076
Ensembl chr10:61,516,078...61,529,076 		JBrowse link
G Sar1b secretion associated Ras related GTPase 1B enables ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:51,654,490...51,682,780
Ensembl chr11:51,654,514...51,682,752 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 28831
    molecular function regulator activity 2167
      G protein activity 60
Path 2
Term Annotations click to browse term
  molecular_function 28831
    catalytic activity 5721
      hydrolase activity 2454
        hydrolase activity, acting on acid anhydrides 697
          hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 696
            pyrophosphatase activity 689
              ribonucleoside triphosphate phosphatase activity 627
                GTPase activity 306
                  G protein activity 60
paths to the root