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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA double-strand break processing
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Accession:GO:0000729 term browser browse the term
Definition:The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang.

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DNA double-strand break processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase involved_in ISO (PMID:10802669), (PMID:26240375) UniProt PMID:10802669 PMID:26240375 NCBI chr 1:99,653,208...99,786,889
Ensembl chr 1:99,653,139...99,791,520 		JBrowse link
G BLM BLM RecQ like helicase involved_in ISO (PMID:21325134) UniProt PMID:21325134 NCBI chr29:9,046,485...9,152,320
Ensembl chr29:9,045,373...9,152,254 		JBrowse link
G DNA2 DNA replication helicase/nuclease 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:62,926,221...62,985,843
Ensembl chr 9:62,926,674...62,985,842 		JBrowse link
G EXD2 exonuclease 3'-5' domain containing 2 involved_in ISO (PMID:26807646) UniProt PMID:26807646 NCBI chr24:46,431,309...46,480,500
Ensembl chr24:46,444,282...46,482,845 		JBrowse link
G EXO1 exonuclease 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr25:78,934,337...78,976,346
Ensembl chr25:78,934,459...78,976,219 		JBrowse link
G MRE11 MRE11 homolog, double strand break repair nuclease involved_in ISO (PMID:23080121) UniProt PMID:23080121 NCBI chr 1:85,615,448...85,694,247
Ensembl chr 1:85,610,819...85,694,269 		JBrowse link
G NBN nibrin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:85,017,807...85,069,219
Ensembl chr 8:85,015,752...85,069,028 		JBrowse link
G RAD50 RAD50 double strand break repair protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:35,375,206...35,458,801
Ensembl chr23:35,375,305...35,458,622 		JBrowse link
G SETMAR SET domain and mariner transposase fusion gene involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr22:40,389,390...40,403,917
Ensembl chr22:40,389,485...40,403,898 		JBrowse link
G SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:42,468,551...42,552,493
Ensembl chr 7:42,498,601...42,553,661 		JBrowse link
G UBE2N ubiquitin conjugating enzyme E2 N involved_in ISO (PMID:17349954) HGNC-UCL PMID:17349954 NCBI chr11:88,810,505...88,842,895 JBrowse link
G UBE2N ubiquitin conjugating enzyme E2 N involved_in IEA Ensembl GO_REF:0000107 Ensembl chr11:88,812,182...88,842,625 JBrowse link
G UBE2V2 ubiquitin conjugating enzyme E2 V2 involved_in ISO (PMID:17349954) HGNC-UCL PMID:17349954 NCBI chr 8:44,167,214...44,218,074 JBrowse link
DNA double-strand break processing involved in repair via single-strand annealing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HELQ helicase, POLQ like involved_in ISO (PMID:34937945) UniProt PMID:34937945 NCBI chr 7:31,799,072...31,846,942
Ensembl chr 7:31,797,747...31,846,760 		JBrowse link
G RAD52 RAD52 homolog, DNA repair protein acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:19506022) MGI
Ensembl		 PMID:19506022 GO_REF:0000107 NCBI chr11:893,984...989,119
Ensembl chr11:895,292...927,430 		JBrowse link
G RBBP8 RB binding protein 8, endonuclease involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr18:57,501,070...57,617,301
Ensembl chr18:57,501,271...57,597,670 		JBrowse link
G RBBP8NL RBBP8 N-terminal like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 2:1,801,775...1,820,209
Ensembl chr 2:1,811,379...1,819,724 		JBrowse link
G RNF138 ring finger protein 138 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr18:48,604,241...48,643,834
Ensembl chr18:48,603,965...48,642,720 		JBrowse link
G SLX1A SLX1 homolog A, structure-specific endonuclease subunit involved_in ISO (PMID:19595721) UniProt PMID:19595721 NCBI chr 5:26,475,234...26,478,844 JBrowse link
G SLX4 SLX4 structure-specific endonuclease subunit involved_in ISO (PMID:19595721) UniProt PMID:19595721 NCBI chr 5:3,281,468...3,308,296 JBrowse link
meiotic DNA double-strand break processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SPO11 SPO11 initiator of meiotic double strand breaks involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 2:6,778,442...6,792,736
Ensembl chr 2:6,778,985...6,792,643 		JBrowse link
meiotic DNA double-strand break processing involved in reciprocal meiotic recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BRIP1 BRCA1 interacting helicase 1 acts_upstream_of_or_within ISO (PMID:26490168) MGI PMID:26490168 NCBI chr16:32,909,226...33,085,551
Ensembl chr16:32,910,693...33,082,587 		JBrowse link
G CUNH14orf39 chromosome unknown C14orf39 homolog involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr24:37,596,061...37,707,136
Ensembl chr24:37,626,089...37,676,361 		JBrowse link
regulation of DNA double-strand break processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HELB DNA helicase B involved_in ISO (PMID:26774285)
(MGI:5766842|PMID:26774285)		 UniProt PMID:26774285 MGI:5766842 NCBI chr11:61,972,061...62,008,532
Ensembl chr11:61,972,161...62,012,631 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16925
    metabolic process 10516
      primary metabolic process 9206
        nucleobase-containing compound metabolic process 5211
          nucleic acid metabolic process 4699
            DNA metabolic process 906
              DNA double-strand break processing 24
                DNA double-strand break processing involved in repair via single-strand annealing 7
                DNA double-strand break processing involved in repair via synthesis-dependent strand annealing 0
                meiotic DNA double-strand break processing + 3
                regulation of DNA double-strand break processing 1
Path 2
Term Annotations click to browse term
  biological_process 16925
    metabolic process 10516
      organic substance metabolic process 10067
        organic cyclic compound metabolic process 5671
          nucleobase-containing compound metabolic process 5211
            nucleic acid metabolic process 4699
              DNA metabolic process 906
                DNA repair 520
                  double-strand break repair 302
                    DNA double-strand break processing 24
                      DNA double-strand break processing involved in repair via single-strand annealing 7
                      DNA double-strand break processing involved in repair via synthesis-dependent strand annealing 0
                      meiotic DNA double-strand break processing + 3
                      regulation of DNA double-strand break processing 1
paths to the root