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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Myeloid Leukemia, Chronic-Phase
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Accession:DOID:9002867 term browser browse the term
Definition:The initial phase of chronic myeloid leukemia consisting of an relatively indolent period lasting from 4 to 7 years. Patients range from asymptomatic to those exhibiting ANEMIA; SPLENOMEGALY; and increased cell turnover. There are 5% or fewer blast cells in the blood and bone marrow in this phase.
Synonyms:exact_synonym: Chronic Granulocytic Leukemia, Stable Phase;   Chronic Myelogenous Leukemia, Chronic Phase;   Chronic Myeloid Leukemia, Chronic Phase;   Chronic Myeloid Leukemia, Stable-Phase;   Granulocytic Leukemia, Chronic Phase;   Myelogenous Leukemia, Chronic Phase;   Myeloid Leukemia, Stable Phase
 primary_id: MESH:D015466


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Myeloid Leukemia, Chronic-Phase term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase disease_progression ISO DNA:hypermethylation:promoter RGD PMID:19344397 PMID:11559572 RGD:11038809, RGD:11038811 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Bcr BCR activator of RhoGEF and GTPase disease_progression ISO RGD PMID:19344397 RGD:11038809 NCBI chr20:13,469,325...13,596,942
Ensembl chr20:13,471,668...13,597,016 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 treatment ISO DNA:polymorphism:intron :6986A>G(human) RGD PMID:23394475 RGD:11353797 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit treatment ISO DNA:SNP: :rs11615 (human) RGD PMID:22821389 RGD:11252165 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963 		JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor disease_progression ISO mRNA,protein:increased expression:mononuclea cell, CD34+ cell RGD PMID:19887785 PMID:23411466 RGD:11040457, RGD:11040461 NCBI chr14:2,040,576...2,056,874
Ensembl chr14:2,042,434...2,051,814 		JBrowse link
G Gfi1b growth factor independent 1B transcriptional repressor ISO mRNA:increased expression:blood: RGD PMID:19360458 RGD:11040460 NCBI chr 3:11,940,232...11,952,989
Ensembl chr 3:11,940,233...11,952,942 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 21126
    disease of cellular proliferation 7669
      Neoplasms by Histologic Type 5261
        leukemia 624
          myeloid leukemia 416
            chronic myeloid leukemia 92
              Myeloid Leukemia, Chronic-Phase 6
Path 2
Term Annotations click to browse term
  disease 21126
    disease of anatomical entity 18213
      Hemic and Lymphatic Diseases 3858
        hematopoietic system disease 3349
          Hematologic Neoplasms 1049
            Bone Marrow Neoplasms 509
              bone marrow cancer 509
                myeloid neoplasm 326
                  chronic myeloid leukemia 92
                    Myeloid Leukemia, Chronic-Phase 6
paths to the root