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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:intracranial hypertension
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Accession:DOID:9428 term browser browse the term
Definition:A brain disease that is characterized by high pressure inside the skull, the brain tissue and cerebrospinal fluid, has_symptom headache, has_symptom vomiting, has_symptom altered mental status, has_symptom papilledema. (DO)
Synonyms:exact_synonym: Elevated Intracranial Pressure;   ICP (intracranial pressure) elevation;   ICP (intracranial pressure) increase;   elevated ICP (intracranial pressure);   intracranial pressure increase;   raised intracranial pressure
 primary_id: MESH:D019586
 xref: EFO:1000992;   NCI:C84791


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intracranial hypertension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp1 aquaporin 1 ISO mRNA:increased expression:neocortex, Pyramidal cells (human) RGD PMID:27487831 RGD:329969876 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690 		JBrowse link
G Htr5a 5-hydroxytryptamine receptor 5A ISO mRNA:increased expression:neocortex,Pyramidal cells (human) RGD PMID:27487831 RGD:329969876 NCBI chr 4:7,444,968...7,454,651
Ensembl chr 4:7,444,968...7,454,651 		JBrowse link
G Kcns1 potassium voltage-gated channel, modifier subfamily S, member 1 ISO mRNA:increased expression:neocortex,Pyramidal cells (human) RGD PMID:27487831 RGD:329969876 NCBI chr 3:152,835,642...152,843,032
Ensembl chr 3:152,835,644...152,842,960 		JBrowse link
G Slc4a10 solute carrier family 4 member 10 ISO CTD Direct Evidence: therapeutic CTD PMID:18165320 NCBI chr 3:46,665,076...46,959,088
Ensembl chr 3:46,665,265...46,957,268 		JBrowse link
hypertensive encephalopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor treatment IEP RGD PMID:24730417 RGD:10059400 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha IDA Strain: SHRSP RGD PMID:20671072 RGD:5509943 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
Posterior Leukoencephalopathy Syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfb1 transforming growth factor, beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29483653 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18969
    disease of anatomical entity 18249
      nervous system disease 14091
        central nervous system disease 12432
          brain disease 11669
            intracranial hypertension 7
              hypertensive encephalopathy + 3
              pseudotumor cerebri + 0
paths to the root