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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Carcinoid Tumor
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Accession:DOID:9007787 term browser browse the term
Definition:A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)
Synonyms:exact_synonym: Argentaffinoma;   Carcinoid;   Carcinoid Tumors;   Carcinoids;   Goblet Cell Carcinoid;   argentaffinomas;   goblet cell carcinoids
 narrow_synonym: Atypical Carcinoid Tumor
 primary_id: MESH:D002276
 xref: EFO:0004243;   EFO:1000097


show annotations for term's descendants           Sort by:
Carcinoid Tumor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin ISO protein:decreased expression:serum: RGD PMID:975003 RGD:11036087 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Eno2 enolase 2, gamma neuronal ISO RGD PMID:17345775 RGD:2293739 NCBI chr 6:124,737,018...124,746,489
Ensembl chr 6:124,737,016...124,746,636 		JBrowse link
G Men1 multiple endocrine neoplasia 1 ISO DNA:loss of heterozygosity:lung:PYGM,D11S449,D11S906(human) RGD PMID:16465412 RGD:2317351 NCBI chr19:6,385,009...6,390,924
Ensembl chr19:6,385,009...6,390,921 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase ISO DNA:hypermethylation:promoter (human) RGD PMID:12584572 RGD:2317635 NCBI chr 7:136,496,315...136,732,001
Ensembl chr 7:136,496,343...136,731,995 		JBrowse link
G Mir10a microRNA 10a ISO CTD Direct Evidence: marker/mechanism CTD PMID:25105010 NCBI chr11:96,207,991...96,208,100
Ensembl chr11:96,207,991...96,208,100 		JBrowse link
G Mir127 microRNA 127 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25105010 NCBI chr12:109,559,280...109,559,349
Ensembl chr12:109,559,280...109,559,349 		JBrowse link
G Mir136 microRNA 136 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25105010 NCBI chr12:109,561,761...109,561,822
Ensembl chr12:109,561,761...109,561,822 		JBrowse link
G Mir146 microRNA 146 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25105010 NCBI chr11:43,265,224...43,265,288
Ensembl chr11:43,265,224...43,265,288 		JBrowse link
G Mir154 microRNA 154 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25105010 NCBI chr12:109,704,867...109,704,932
Ensembl chr12:109,704,867...109,704,932 		JBrowse link
G Mir155 microRNA 155 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25105010 NCBI chr16:84,511,028...84,511,092
Ensembl chr16:84,511,028...84,511,092 		JBrowse link
G Mir193a microRNA 193a ISO CTD Direct Evidence: marker/mechanism CTD PMID:25105010 NCBI chr11:79,602,795...79,602,860
Ensembl chr11:79,602,795...79,602,860 		JBrowse link
G Mir222 microRNA 222 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25105010 NCBI chr  X:19,013,132...19,013,210
Ensembl chr  X:19,013,132...19,013,210 		JBrowse link
G Mir224 microRNA 224 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25105010 NCBI chr  X:71,304,637...71,304,718
Ensembl chr  X:71,304,637...71,304,718 		JBrowse link
G Mir302d microRNA 302d ISO CTD Direct Evidence: marker/mechanism CTD PMID:25105010 NCBI chr 3:127,339,273...127,339,338
Ensembl chr 3:127,339,273...127,339,338 		JBrowse link
G Mir30a microRNA 30a ISO CTD Direct Evidence: marker/mechanism CTD PMID:25105010 NCBI chr 1:23,311,350...23,311,420
Ensembl chr 1:23,311,350...23,311,420 		JBrowse link
G Mir34b microRNA 34b ISO CTD Direct Evidence: marker/mechanism CTD PMID:25105010 NCBI chr 9:51,014,862...51,014,945
Ensembl chr 9:51,014,862...51,014,945 		JBrowse link
G Mir34c microRNA 34c ISO CTD Direct Evidence: marker/mechanism CTD PMID:25105010 NCBI chr 9:51,014,334...51,014,410
Ensembl chr 9:51,014,334...51,014,410 		JBrowse link
G Mir369 microRNA 369 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25105010 NCBI chr12:109,709,852...109,709,930
Ensembl chr12:109,709,852...109,709,930 		JBrowse link
G Mir370 microRNA 370 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25105010 NCBI chr12:109,584,692...109,584,770
Ensembl chr12:109,584,692...109,584,770 		JBrowse link
G Mir409 microRNA 409 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25105010 NCBI chr12:109,709,592...109,709,670
Ensembl chr12:109,709,592...109,709,670 		JBrowse link
G Mir410 microRNA 410 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25105010 NCBI chr12:109,710,149...109,710,229
Ensembl chr12:109,710,149...109,710,229 		JBrowse link
G Mir432 microRNA 432 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25105010 NCBI chr12:109,561,390...109,561,464
Ensembl chr12:109,561,390...109,561,464 		JBrowse link
G Mir487b microRNA 487b ISO CTD Direct Evidence: marker/mechanism CTD PMID:25105010 NCBI chr12:109,693,767...109,693,848
Ensembl chr12:109,693,767...109,693,848 		JBrowse link
G Mir494 microRNA 494 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25105010 NCBI chr12:109,681,752...109,681,836
Ensembl chr12:109,681,752...109,681,836 		JBrowse link
G Mir511 microRNA 511 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25105010 NCBI chr 2:14,265,814...14,265,892
Ensembl chr 2:14,265,814...14,265,892 		JBrowse link
G Reg1 regenerating islet-derived 1 ISO associated with Hypergastrinemia;DNA:missense mutations:cds:multiple (human) RGD PMID:10348814 RGD:9850135 NCBI chr 6:78,402,966...78,405,651
Ensembl chr 6:78,399,694...78,405,650 		JBrowse link
Intestinal Carcinoid Tumors term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nap1l1 nucleosome assembly protein 1-like 1 ISO mRNA:increased expression:intestinal mucosa (human) RGD PMID:16424981 RGD:9590082 NCBI chr10:111,308,754...111,334,011
Ensembl chr10:111,309,084...111,334,011 		JBrowse link
G Sdhd succinate dehydrogenase complex, subunit D, integral membrane protein ISO ClinVar Annotator: match by term: Carcinoid tumors, intestinal ClinVar PMID:12007193 PMID:12111639 PMID:12386824 PMID:12696072 PMID:14557476 More... NCBI chr 9:50,507,640...50,515,149
Ensembl chr 9:50,507,657...50,515,112 		JBrowse link
Lung Carcinoid Tumors term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atrx ATRX, chromatin remodeler disease_progression ISO protein:decreased expression:nucleus, lung RGD PMID:31499081 RGD:127285379 NCBI chr  X:104,841,221...104,972,978
Ensembl chr  X:104,841,221...104,973,009 		JBrowse link
G Col4a3 collagen, type IV, alpha 3 severity ISO mRNA:decreased expression:lung (human) RGD PMID:25105010 RGD:151660336 NCBI chr 1:82,564,647...82,699,778
Ensembl chr 1:82,564,642...82,699,780 		JBrowse link
G Creb5 cAMP responsive element binding protein 5 severity ISO mRNA:decreased expression:lung (human) RGD PMID:25105010 RGD:151660336 NCBI chr 6:53,264,154...53,677,349
Ensembl chr 6:53,264,255...53,677,361 		JBrowse link
G Men1 multiple endocrine neoplasia 1 ISO ClinVar Annotator: match by term: Lung carcinoid tumor ClinVar PMID:9215689 PMID:9361035 PMID:9463336 PMID:9709921 PMID:11303512 More... NCBI chr19:6,385,009...6,390,924
Ensembl chr19:6,385,009...6,390,921 		JBrowse link
G Ptprb protein tyrosine phosphatase receptor type B severity ISO mRNA:decreased expression:lung (human) RGD PMID:25105010 RGD:151660336 NCBI chr10:116,111,407...116,225,443
Ensembl chr10:116,111,428...116,225,440 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16121
    disease of anatomical entity 15680
      endocrine system disease 6334
        endocrine gland cancer 2449
          neuroendocrine tumor 221
            Carcinoid Tumor 32
              Intestinal Carcinoid Tumors 2
              Lung Carcinoid Tumors 5
              Malignant Carcinoid Syndrome + 0
              Neurofibromatosis-Pheochromocytoma-Duodenal Carcinoid Syndrome 0
Path 2
Term Annotations click to browse term
  disease 16121
    disease of cellular proliferation 7571
      Neoplasms by Site 7029
        organ system cancer 5290
          nervous system cancer 965
            neuroectodermal tumor 476
              neuroendocrine tumor 221
                Carcinoid Tumor 32
                  Intestinal Carcinoid Tumors 2
                  Lung Carcinoid Tumors 5
                  Malignant Carcinoid Syndrome + 0
                  Neurofibromatosis-Pheochromocytoma-Duodenal Carcinoid Syndrome 0
paths to the root