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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Hemorrhagic Shock
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Accession:DOID:9001708 term browser browse the term
Definition:Acute hemorrhage or excessive fluid loss resulting in HYPOVOLEMIA.
Synonyms:primary_id: MESH:D012771

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Hemorrhagic Shock term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin treatment ISO RGD PMID:15973109 PMID:18403050 RGD:7364987 RGD:7364990 NCBI chrNW_004936528:8,005,223...8,007,586
Ensembl chrNW_004936528:8,005,189...8,007,643 		JBrowse link
G Angpt1 angiopoietin 1 ISO RGD PMID:18344375 RGD:2316067 NCBI chrNW_004936470:37,105,469...37,328,183
Ensembl chrNW_004936470:37,105,466...37,328,190 		JBrowse link
G Arg2 arginase 2 ISO protein:increased expression:aorta (rat) RGD PMID:20699748 RGD:4143274 NCBI chrNW_004936495:11,004,296...11,045,467
Ensembl chrNW_004936495:11,004,176...11,045,472 		JBrowse link
G Bad BCL2 associated agonist of cell death ISO protein:decreased serine phosphorylation:lung RGD PMID:15345971 RGD:2292699 NCBI chrNW_004936599:4,924,349...4,933,683
Ensembl chrNW_004936599:4,924,789...4,933,368 		JBrowse link
G Bcl2 BCL2 apoptosis regulator ISO mRNA:increased expression:intestine RGD PMID:17693937 RGD:2293072 NCBI chrNW_004936497:2,209,136...2,373,580
Ensembl chrNW_004936497:2,210,334...2,210,921 		JBrowse link
G Bcl2l1 BCL2 like 1 ISO protein:increased expression:liver, mitochondrion RGD PMID:17224795 RGD:1643525 NCBI chrNW_004936485:18,654,046...18,707,324 JBrowse link
G Casp3 caspase 3 ISO associated with Brain Injuries, Traumatic RGD PMID:29061477 RGD:13782298 NCBI chrNW_004936554:4,571,072...4,593,765 JBrowse link
G Casp8 caspase 8 ISO associated with Brain Injuries, Traumatic RGD PMID:29061477 RGD:13782298 NCBI chrNW_004936726:554,627...596,334
Ensembl chrNW_004936726:554,758...595,922 		JBrowse link
G Cnr1 cannabinoid receptor 1 ISO mRNA, protein:increased expression:aorta, mesenteric artery RGD PMID:19493421 RGD:2314664 NCBI chrNW_004936510:3,779,930...3,806,615
Ensembl chrNW_004936510:3,781,210...3,802,693 		JBrowse link
G Cul5 cullin 5 ISO mRNA:altered expression:brain RGD PMID:12635525 RGD:2301433 NCBI chrNW_004936551:641,469...724,706
Ensembl chrNW_004936551:641,463...724,711 		JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:20539178 RGD:10401059 NCBI chrNW_004936543:742,722...745,332
Ensembl chrNW_004936543:743,537...745,343 		JBrowse link
G Esr1 estrogen receptor 1 severity ISO RGD PMID:20195535 RGD:4892252 NCBI chrNW_004936489:4,616,839...4,887,179
Ensembl chrNW_004936489:4,614,754...4,887,171 		JBrowse link
G Esr2 estrogen receptor 2 ISO RGD PMID:16859701 RGD:8694176 NCBI chrNW_004936495:7,956,168...8,018,356
Ensembl chrNW_004936495:7,956,766...8,004,357 		JBrowse link
G F2 coagulation factor II, thrombin ISO protein:decreased activity:blood (rat) RGD PMID:21550061 RGD:5132267 NCBI chrNW_004936562:2,371,725...2,388,617
Ensembl chrNW_004936562:2,372,044...2,388,650 		JBrowse link
G F8 coagulation factor VIII ISO protein:decreased expression:plasma RGD PMID:15748447 RGD:10450768 NCBI chrNW_004936927:189,359...301,791
Ensembl chrNW_004936927:190,111...301,609 		JBrowse link
G Gfer growth factor, augmenter of liver regeneration ISO RGD PMID:23073658 RGD:9685733 NCBI chrNW_004936694:2,051,362...2,053,812
Ensembl chrNW_004936694:2,051,325...2,053,818 		JBrowse link
G Gja1 gap junction protein alpha 1 ISO RGD PMID:19077877 RGD:7207423 NCBI chrNW_004936658:3,920,043...3,932,987
Ensembl chrNW_004936658:3,920,043...3,932,987 		JBrowse link
G Gja5 gap junction protein alpha 5 ISO RGD PMID:19077877 RGD:7207423 NCBI chrNW_004936867:269,477...279,549 JBrowse link
G Glul glutamate-ammonia ligase treatment ISO RGD PMID:12766648 RGD:401794596 NCBI chrNW_004936481:7,293,301...7,301,416
Ensembl chrNW_004936481:7,293,091...7,306,202 		JBrowse link
G Gpt glutamic--pyruvic transaminase treatment ISO RGD PMID:16141011 RGD:401717565 NCBI chrNW_004936470:7,765,810...7,770,837
Ensembl chrNW_004936470:7,765,703...7,768,465 		JBrowse link
G Hmox1 heme oxygenase 1 severity ISO RGD PMID:20514418 PMID:20819606 RGD:10755719 RGD:10755727 NCBI chrNW_004936492:5,042,353...5,049,216
Ensembl chrNW_004936492:5,042,330...5,049,311 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:lung (mouse)		 CTD
RGD		 PMID:19828841 PMID:21192278 RGD:4145497 NCBI chrNW_004936659:616,570...627,172
Ensembl chrNW_004936659:616,752...627,174 		JBrowse link
G Ifng interferon gamma ISO protein:increased expression:plasma RGD PMID:19439114 RGD:2311495 NCBI chrNW_004936545:6,139,130...6,144,543
Ensembl chrNW_004936545:6,139,116...6,148,452 		JBrowse link
G Il10 interleukin 10 ISO protein:increased expression:serum, lymph RGD PMID:19160132 RGD:2311060 NCBI chrNW_004936557:5,834,874...5,838,502
Ensembl chrNW_004936557:5,834,874...5,838,502 		JBrowse link
G Il18 interleukin 18 ISO protein:increased expression:plasma RGD PMID:23589298 RGD:14695541 NCBI chrNW_004936612:2,306,963...2,325,086
Ensembl chrNW_004936612:2,306,875...2,325,189 		JBrowse link
G Il1a interleukin 1 alpha ISO mRNA:increased expression:lung RGD PMID:15580020 RGD:2311100 NCBI chrNW_004936783:1,210,715...1,218,315
Ensembl chrNW_004936783:1,210,809...1,218,315 		JBrowse link
G Il1b interleukin 1 beta severity ISO protein:increased expression:kidney, serum (rat)
mRNA:increased expression:lung		 RGD PMID:15580020 PMID:17545943 PMID:21336199 RGD:1626655 RGD:2311100 RGD:7175325 NCBI chrNW_004936783:1,251,678...1,256,807
Ensembl chrNW_004936783:1,252,158...1,257,165 		JBrowse link
G Il6 interleukin 6 ISO protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:21168948 PMID:21192278 RGD:5128673 NCBI chrNW_004936549:7,015,595...7,016,246 JBrowse link
G LOC101956126 heat shock 70 kDa protein 1 ISO mRNA:increased expression:liver RGD PMID:22266570 RGD:7257601 NCBI chrNW_004936727:1,732,323...1,735,128 JBrowse link
G LOC101976500 haptoglobin ISO RGD PMID:20016403 RGD:5147418 NCBI chrNW_004936475:21,841,054...21,845,821 JBrowse link
G Mapk1 mitogen-activated protein kinase 1 ISO protein: increased expression: lung and liver RGD PMID:22392145 RGD:7244173 NCBI chrNW_004936619:1,889,841...1,932,646
Ensembl chrNW_004936619:1,889,708...1,932,646 		JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment ISO RGD PMID:16141011 RGD:401717565 NCBI chrNW_004936514:7,038,240...7,045,873
Ensembl chrNW_004936514:7,037,639...7,045,793 		JBrowse link
G Mpo myeloperoxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:21192278 NCBI chrNW_004936490:4,809,773...4,819,070
Ensembl chrNW_004936490:4,809,631...4,819,070 		JBrowse link
G Mtor mechanistic target of rapamycin kinase treatment ISO RGD PMID:24204984 RGD:10041042 NCBI chrNW_004936474:158,376...282,310
Ensembl chrNW_004936474:157,590...282,342 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor treatment ISO RGD PMID:22113495 RGD:7240568 NCBI chrNW_004936470:20,480,844...20,485,955
Ensembl chrNW_004936470:20,480,829...20,485,965 		JBrowse link
G Nfkbia NFKB inhibitor alpha treatment ISO RGD PMID:11557243 RGD:127285020 NCBI chrNW_004936494:9,537,793...9,541,187
Ensembl chrNW_004936494:9,537,008...9,541,612 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO mRNA, protein:increased expression:multiple RGD PMID:15854664 RGD:1580937 NCBI chrNW_004936538:4,052,277...4,097,051
Ensembl chrNW_004936538:4,052,448...4,097,051 		JBrowse link
G Nos3 nitric oxide synthase 3 treatment ISO mRNA:increased expression: :multiple RGD PMID:15854664 PMID:29122552 RGD:13450929 RGD:1580937 NCBI chrNW_004936527:6,427,147...6,445,770
Ensembl chrNW_004936527:6,427,093...6,446,534 		JBrowse link
G Otc ornithine transcarbamylase ISO protein:increased activity:serum (rat) RGD PMID:17224795 RGD:1643525 NCBI chrNW_004936502:5,234,253...5,291,891
Ensembl chrNW_004936502:5,234,253...5,291,891 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO protein:increased phosphorylation:nucleus, liver
protein:increased phosphorylation, altered location:nucleus, endothelial cell, lung		 RGD PMID:17950078 PMID:17950083 PMID:18469645 RGD:2298781 RGD:2298841 RGD:2298842 NCBI chrNW_004936599:3,800,142...3,810,583
Ensembl chrNW_004936599:3,801,636...3,809,813 		JBrowse link
G Sirt1 sirtuin 1 treatment ISO protein:decreased expression:heart left ventricle RGD PMID:21554952 PMID:22113495 RGD:7240568 RGD:9585770 NCBI chrNW_004936521:10,296,097...10,316,673
Ensembl chrNW_004936521:10,296,097...10,322,215 		JBrowse link
G Slc9a1 solute carrier family 9 member A1 ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:17724433 PMID:19384202 RGD:6771334 NCBI chrNW_004936474:11,460,266...11,517,420
Ensembl chrNW_004936474:11,459,929...11,517,478 		JBrowse link
G Sod2 superoxide dismutase 2 treatment ISO RGD PMID:26073907 RGD:26923954 NCBI chrNW_004936489:11,178,338...11,191,601
Ensembl chrNW_004936489:11,178,015...11,191,781 		JBrowse link
G Tfam transcription factor A, mitochondrial ISO RGD PMID:22469910 RGD:6767567 NCBI chrNW_004936614:4,595,973...4,605,040
Ensembl chrNW_004936614:4,596,617...4,605,104 		JBrowse link
G Tgfb1 transforming growth factor beta 1 treatment ISO RGD PMID:16141011 RGD:401717565 NCBI chrNW_004936661:3,742,080...3,758,266
Ensembl chrNW_004936661:3,742,066...3,758,272 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 treatment ISO RGD PMID:16141011 RGD:401717565 NCBI chrNW_004936502:13,345,936...13,350,170
Ensembl chrNW_004936502:13,345,832...13,350,248 		JBrowse link
G Tlr4 toll like receptor 4 severity ISO RGD PMID:25049041 RGD:14697700 NCBI chrNW_004936487:6,519,140...6,532,018
Ensembl chrNW_004936487:6,518,441...6,533,095 		JBrowse link
G Tnf tumor necrosis factor treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:21192278 PMID:24315526 RGD:10450602 NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766 		JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 ameliorates ISO RGD PMID:19333144 RGD:127284838 NCBI chrNW_004936476:18,577,825...18,583,675
Ensembl chrNW_004936476:18,574,381...18,583,647 		JBrowse link
G Vwf von Willebrand factor ISO protein:decreased expression:plasma RGD PMID:15748447 RGD:10450768 NCBI chrNW_004936709:1,578,137...1,741,877
Ensembl chrNW_004936709:1,579,096...1,741,754 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14499
    Pathological Conditions, Signs and Symptoms 11295
      Pathologic Processes 7002
        Hemorrhage 260
          Hemorrhagic Shock 50
            Hemorrhagic Shock and Encephalopathy Syndrome 0
paths to the root