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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Middle East respiratory syndrome
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Accession:DOID:0080642 term browser browse the term
Definition:A Coronavirus infectious disease that is characterized by severe respiratory illness, including fever, cough, and shortness of breath and that has_material_basis_in MERS-CoV. (DO)
Synonyms:exact_synonym: MERS;   MERS (Middle East respiratory syndrome)


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Middle East respiratory syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg1 arginase 1 ISO mRNA:increased expression:lung RGD PMID:31838832 RGD:30309204 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422 		JBrowse link
G C5ar1 complement C5a receptor 1 treatment ISO RGD PMID:30634407 RGD:30309958 NCBI chr 1:76,948,622...76,959,826 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 ISO RGD PMID:30626685 RGD:30309198 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 ISO RGD PMID:30626685 RGD:30309198 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Cd14 CD14 molecule ISO mRNA:increased expression:lung RGD PMID:31838832 RGD:30309204 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cd40lg CD40 ligand treatment ISO RGD PMID:30911758 RGD:32716379 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO RGD PMID:30626685 RGD:30309198 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO RGD PMID:30626685 RGD:30309198 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435 		JBrowse link
G Dpp4 dipeptidylpeptidase 4 severity
treatment		 ISS
ISO		 human gene in mouse model MouseDO
RGD		 PMID:30626685 PMID:31838832 PMID:30256968 RGD:30309198, RGD:30309204, RGD:30309959 NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901 		JBrowse link
G Ifna4 interferon, alpha 4 disease_progression ISO RGD PMID:30626685 RGD:30309198 NCBI chr 5:103,069,174...103,070,120
Ensembl chr 5:103,069,483...103,070,052 		JBrowse link
G Ifnb1 interferon beta 1 disease_progression ISO RGD PMID:30626685 RGD:30309198 NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523 		JBrowse link
G Ifng interferon gamma treatment ISO RGD PMID:30634407 RGD:30309958 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 ISO mRNA:increased expression:lung (mouse) RGD PMID:32364527 RGD:27226699 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1a interleukin 1 alpha onset ISO mRNA:increased expression:lung (mouse) RGD PMID:32364527 RGD:27226699 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta onset
treatment		 ISO mRNA:increased expression:lung (mouse) RGD PMID:32364527 PMID:30626685 PMID:30634407 RGD:27226699, RGD:30309198, RGD:30309958 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il23a interleukin 23 subunit alpha ISO mRNA:decreased expression:lung (mouse) RGD PMID:32364527 RGD:27226699 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
G Il6 interleukin 6 ISO protein:increased expression:serum: RGD PMID:30626685 PMID:30634407 RGD:30309198, RGD:30309958 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il7 interleukin 7 onset ISO mRNA:altered expression:lung (mouse) RGD PMID:32364527 RGD:27226699 NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075 		JBrowse link
G Tnf tumor necrosis factor ISO protein:increased expression:serum: RGD PMID:30634407 RGD:30309958 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18969
    disease by infectious agent 2215
      viral infectious disease 1677
        RNA Virus Infections 1397
          Nidovirales Infections 1023
            Coronaviridae Infections 1023
              Coronavirus infectious disease 1022
                Middle East respiratory syndrome 19
paths to the root