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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,2',4,5'-Tetrabromodiphenyl ether
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Accession:CHEBI:81583 term browser browse the term
Definition:An organobromine compound that has formula C12H6Br4O.
Synonyms:related_synonym: BDE 49;   Formula=C12H6Br4O;   InChI=1S/C12H6Br4O/c13-7-2-4-11(10(16)5-7)17-12-6-8(14)1-3-9(12)15/h1-6H;   InChIKey=QWVDUBDYUPHNHY-UHFFFAOYSA-N;   PBDE 49;   SMILES=Brc1ccc(Oc2cc(Br)ccc2Br)c(Br)c1
 xref: CAS:243982-82-3;   KEGG:C18204
 xref_mesh: MESH:C572625


show annotations for term's descendants           Sort by:
2,2',4,5'-Tetrabromodiphenyl ether term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions ISO 2,2',4,5'-tetrabromodiphenyl ether metabolite inhibits the reaction [Thyroxine binds to ALB protein] CTD PMID:29283575 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Ar androgen receptor multiple interactions ISO 2,2',4,5'-tetrabromodiphenyl ether inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases chemical synthesis ISO CYP2B6 protein results in increased chemical synthesis of 2,2',4,5'-tetrabromodiphenyl ether analog CTD PMID:23249762 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO 2,2',4,5'-tetrabromodiphenyl ether analog binds to and results in decreased activity of ESR1 protein CTD PMID:23603053 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 multiple interactions ISO 2,2',4,5'-tetrabromodiphenyl ether analog inhibits the reaction [Estradiol analog binds to GPER1 protein] CTD PMID:29790728 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889 		JBrowse link
G Hdc histidine decarboxylase increases expression EXP 2,2',4,5'-tetrabromodiphenyl ether metabolite results in increased expression of HDC mRNA CTD PMID:29357290 NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341 		JBrowse link
G Iyd iodotyrosine deiodinase decreases activity ISO 2,2',4,5'-tetrabromodiphenyl ether analog results in decreased activity of IYD protein CTD PMID:24012475 NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319 		JBrowse link
G Slc25a25 solute carrier family 25 member 25 increases expression EXP 2,2',4,5'-tetrabromodiphenyl ether metabolite results in increased expression of SLC25A25 mRNA CTD PMID:29357290 NCBI chr 3:15,708,702...15,742,195
Ensembl chr 3:15,708,703...15,742,216 		JBrowse link
G Ttr transthyretin multiple interactions ISO 2,2',4,5'-tetrabromodiphenyl ether metabolite inhibits the reaction [Thyroxine binds to TTR protein] CTD PMID:29283575 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19834
    chemical entity 19832
      molecular entity 19832
        main group molecular entity 19782
          p-block molecular entity 19782
            halogen molecular entity 18673
              bromine molecular entity 6647
                organobromine compound 6582
                  2,2',4,5'-Tetrabromodiphenyl ether 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19834
    subatomic particle 19832
      composite particle 19832
        hadron 19832
          baryon 19832
            nucleon 19832
              atomic nucleus 19832
                atom 19832
                  main group element atom 19782
                    p-block element atom 19782
                      carbon group element atom 19731
                        carbon atom 19727
                          organic molecular entity 19727
                            heteroorganic entity 19484
                              organochalcogen compound 19248
                                organooxygen compound 19165
                                  ether 17280
                                    aromatic ether 16526
                                      2,2',4,5'-Tetrabromodiphenyl ether 9
paths to the root