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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Methazolamide
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Accession:CHEBI:6822 term browser browse the term
Definition:A thiadiazole that has formula C5H8N4O3S2.
Synonyms:related_synonym: Formula=C5H8N4O3S2;   InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)/b7-4+;   InChIKey=FLOSMHQXBMRNHR-QPJJXVBHSA-N;   SMILES=CC(=O)\\N=c1\\sc(nn1C)S(N)(=O)=O
 xref: CAS:554-57-4;   KEGG:C07764;   KEGG:D00655
 xref_mesh: MESH:D008704


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Methazolamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Car1 carbonic anhydrase 1 multiple interactions ISO Methazolamide binds to and results in decreased activity of CA1 protein CTD PMID:17826101 NCBI chr 3:14,831,274...14,873,425
Ensembl chr 3:14,831,276...14,873,428 		JBrowse link
G Car2 carbonic anhydrase 2 decreases activity
multiple interactions		 ISO Methazolamide results in decreased activity of CA2 protein
Methazolamide binds to and results in decreased activity of CA2 protein		 CTD PMID:16858005 PMID:17826101 NCBI chr 3:14,951,329...14,965,830
Ensembl chr 3:14,951,333...14,965,830 		JBrowse link
G Car3 carbonic anhydrase 3 multiple interactions ISO Methazolamide binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 3:14,928,598...14,937,441
Ensembl chr 3:14,928,572...14,937,583 		JBrowse link
G Clu clusterin affects expression ISO Methazolamide affects the expression of CLU protein CTD PMID:12388792 NCBI chr14:66,206,093...66,218,992
Ensembl chr14:66,205,932...66,218,996 		JBrowse link
G Gal galanin and GMAP prepropeptide affects expression ISO Methazolamide affects the expression of GAL protein CTD PMID:12388792 NCBI chr19:3,459,915...3,464,544
Ensembl chr19:3,459,915...3,464,544 		JBrowse link
G Gap43 growth associated protein 43 affects expression ISO Methazolamide affects the expression of GAP43 protein CTD PMID:12388792 NCBI chr16:42,068,915...42,161,014
Ensembl chr16:42,068,805...42,161,014 		JBrowse link
G Ret ret proto-oncogene affects expression ISO Methazolamide affects the expression of RET protein CTD PMID:12388792 NCBI chr 6:118,128,709...118,174,705
Ensembl chr 6:118,128,706...118,174,679 		JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 affects expression ISO Methazolamide affects the expression of TIMP1 protein CTD PMID:12388792 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22210
    chemical entity 22209
      atom 22202
        nonmetal atom 22086
          sulfur atom 18708
            sulfur molecular entity 18708
              organosulfur compound 18121
                sulfonamide 5306
                  Methazolamide 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 22210
    subatomic particle 22202
      composite particle 22202
        hadron 22202
          baryon 22202
            nucleon 22202
              atomic nucleus 22202
                atom 22202
                  main group element atom 22136
                    p-block element atom 22136
                      chalcogen 21465
                        oxygen atom 21443
                          oxygen molecular entity 21443
                            hydroxides 20822
                              oxoacid 20141
                                chalcogen oxoacid 14384
                                  sulfur oxoacid 14169
                                    sulfonic acid 12009
                                      sulfonic acid derivative 12009
                                        sulfonamide 5306
                                          Methazolamide 8
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