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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:mibolerone
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Accession:CHEBI:34849 term browser browse the term
Definition:An androgen that is nalandrone carrying two methyl substituents at positions 7alpha and 17.
Synonyms:exact_synonym: 17beta-hydroxy-7alpha,17-dimethylestr-4-en-3-one
 related_synonym: (7alpha,17beta)-17-hydroxy-7,17-dimethylestr-4-en-3-one;   17-beta-Hydroxy-7-alpha,17-dimethylestr-4-en-3-one;   7alpha-17alpha-dimethyl-19-nortestosterone;   Formula=C20H30O2;   InChI=1S/C20H30O2/c1-12-10-13-11-14(21)4-5-15(13)16-6-8-19(2)17(18(12)16)7-9-20(19,3)22/h11-12,15-18,22H,4-10H2,1-3H3/t12-,15+,16-,17+,18-,19+,20+/m1/s1;   InChIKey=PTQMMNYJKCSPET-OMHQDGTGSA-N;   NSC 72260;   SMILES=[H][C@]12CCC(=O)C=C1C[C@@H](C)[C@]1([H])[C@]2([H])CC[C@@]2(C)[C@@]1([H])CC[C@]2(C)O;   U 10997;   U-10,997;   mibolerona;   miboleronum
 xref: Beilstein:5565683;   CAS:3704-09-4;   KEGG:C14255;   KEGG:D05025
 xref_mesh: MESH:C100075
 xref: PMID:18515094;   PMID:18770362;   PMID:209430;   PMID:2151880;   PMID:2410244;   PMID:2417401;   PMID:2422638;   PMID:3265669;   PMID:3930306;   PMID:3934110;   PMID:405963;   PMID:4070927;   PMID:565606;   PMID:6254486;   PMID:869826;   PMID:921032;   Patent:US2002012694;   Patent:US2002193359;   Patent:US4412993;   Patent:US5342834;   Reaxys:5565683;   Wikipedia:Mibolerone


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mibolerone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adi1 acireductone dioxygenase 1 increases expression ISO mibolerone results in increased expression of ADI1 mRNA; mibolerone results in increased expression of ADI1 protein CTD PMID:17786183 NCBI chr 6:45,306,885...45,313,847
Ensembl chr 6:45,306,841...45,313,842 		JBrowse link
G Ar androgen receptor multiple interactions
affects localization
increases activity
affects binding
increases localization
increases expression
increases phosphorylation		 ISO
EXP		 [mibolerone binds to and results in increased activity of AR protein] inhibits the reaction [ETS1 protein results in increased expression of MMP1 mRNA]; [mibolerone binds to and results in increased activity of AR protein] inhibits the reaction [ETV4 protein results in increased expression of MMP1 mRNA]; [mibolerone binds to and results in increased activity of AR protein] inhibits the reaction [ETV5 protein results in increased expression of MMP1 mRNA]; [Quercetin co-treated with mibolerone] promotes the reaction [AR protein binds to JUN protein]; [Quercetin co-treated with mibolerone] promotes the reaction [SP1 protein binds to JUN protein binds to AR protein]; mibolerone inhibits the reaction [bicalutamide results in increased expression of AR protein]; mibolerone promotes the reaction [SP1 protein binds to AR protein]; nilutamide inhibits the reaction [mibolerone affects the localization of AR protein]; pyrazolanthrone affects the reaction [Quercetin inhibits the reaction [mibolerone results in increased expression of AR protein]]; Quercetin affects the reaction [mibolerone affects the localization of AR protein]; Quercetin inhibits the reaction [mibolerone results in increased expression of AR protein]; Quercetin inhibits the reaction [mibolerone results in increased phosphorylation of AR protein]; Quercetin promotes the reaction [mibolerone promotes the reaction [SP1 protein binds to AR protein]]; retigeric acid B inhibits the reaction [mibolerone results in increased expression of AR protein]
mibolerone results in increased activity of AR protein
mibolerone binds to AR protein
mibolerone results in increased localization of AR protein
EGF protein promotes the reaction [mibolerone binds to AR protein]		 CTD PMID:8798622 PMID:8912815 PMID:12676605 PMID:14565775 PMID:15253041 More... NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO EGF protein promotes the reaction [mibolerone binds to AR protein] CTD PMID:8912815 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor multiple interactions ISO [mibolerone binds to and results in increased activity of AR protein] inhibits the reaction [ETS1 protein results in increased expression of MMP1 mRNA] CTD PMID:8798622 NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010 		JBrowse link
G Etv4 ETS variant transcription factor 4 multiple interactions ISO [mibolerone binds to and results in increased activity of AR protein] inhibits the reaction [ETV4 protein results in increased expression of MMP1 mRNA] CTD PMID:8798622 NCBI chr10:86,706,749...86,721,974
Ensembl chr10:86,706,749...86,721,974 		JBrowse link
G Etv5 ETS variant transcription factor 5 multiple interactions ISO [mibolerone binds to and results in increased activity of AR protein] inhibits the reaction [ETV5 protein results in increased expression of MMP1 mRNA] CTD PMID:8798622 NCBI chr11:78,608,618...78,666,221
Ensembl chr11:78,608,710...78,666,215 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Quercetin co-treated with mibolerone] promotes the reaction [AR protein binds to JUN protein]; [Quercetin co-treated with mibolerone] promotes the reaction [SP1 protein binds to JUN protein binds to AR protein]; [Quercetin co-treated with mibolerone] promotes the reaction [SP1 protein binds to JUN protein]; [Quercetin co-treated with mibolerone] results in increased phosphorylation of JUN protein; pyrazolanthrone inhibits the reaction [[Quercetin co-treated with mibolerone] results in increased phosphorylation of JUN protein] CTD PMID:20148354 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 multiple interactions
increases expression
increases secretion		 ISO methylselenic acid inhibits the reaction [mibolerone results in increased expression of KLK3 mRNA]; mibolerone inhibits the reaction [bicalutamide results in increased expression of KLK3 protein]; Resveratrol inhibits the reaction [mibolerone results in increased expression of KLK3 mRNA]; Resveratrol inhibits the reaction [mibolerone results in increased expression of KLK3 protein]
mibolerone results in increased expression of KLK3 mRNA; mibolerone results in increased expression of KLK3 protein
mibolerone results in increased secretion of KLK3 protein		 CTD PMID:10606230 PMID:15141018 PMID:17723170 PMID:25846647 NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052 		JBrowse link
G Mir196b microRNA 196b decreases expression ISO mibolerone results in decreased expression of MIR196B mRNA CTD PMID:25846647 NCBI chr 4:81,330,487...81,330,571
Ensembl chr 4:81,330,487...81,330,571 		JBrowse link
G Mir210 microRNA 210 increases expression ISO mibolerone results in increased expression of MIR210 mRNA CTD PMID:25846647 NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454 		JBrowse link
G Mir221 microRNA 221 decreases expression ISO mibolerone results in decreased expression of MIR221 mRNA CTD PMID:25846647 NCBI chr  X:3,429,465...3,429,573
Ensembl chr  X:3,429,465...3,429,573 		JBrowse link
G Mir30a microRNA 30a decreases expression ISO mibolerone results in decreased expression of MIR30A mRNA CTD PMID:25846647 NCBI chr 9:25,737,600...25,737,670
Ensembl chr 9:25,737,600...25,737,670 		JBrowse link
G Mir99a microRNA 99a decreases expression ISO mibolerone results in decreased expression of MIR99A mRNA CTD PMID:25846647 NCBI chr11:16,200,443...16,200,523
Ensembl chr11:16,200,443...16,200,523 		JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO [mibolerone binds to and results in increased activity of AR protein] inhibits the reaction [ETS1 protein results in increased expression of MMP1 mRNA]; [mibolerone binds to and results in increased activity of AR protein] inhibits the reaction [ETV4 protein results in increased expression of MMP1 mRNA]; [mibolerone binds to and results in increased activity of AR protein] inhibits the reaction [ETV5 protein results in increased expression of MMP1 mRNA]; mibolerone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP1 mRNA] CTD PMID:8798622 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO mibolerone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA] CTD PMID:8798622 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO mibolerone results in decreased expression of MMP7 mRNA CTD PMID:8798622 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902 		JBrowse link
G Nkx3-1 NK3 homeobox 1 multiple interactions
increases expression		 ISO Flufenamic Acid inhibits the reaction [mibolerone results in increased expression of NKX3-1 mRNA]; Piroxicam inhibits the reaction [mibolerone results in increased expression of NKX3-1 mRNA] CTD PMID:10537180 NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441 		JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions ISO mibolerone promotes the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]; perchlorate inhibits the reaction [mibolerone promotes the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]] CTD PMID:14633711 NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697 		JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO [Quercetin co-treated with mibolerone] promotes the reaction [SP1 protein binds to JUN protein binds to AR protein]; [Quercetin co-treated with mibolerone] promotes the reaction [SP1 protein binds to JUN protein]; mibolerone promotes the reaction [SP1 protein binds to AR protein]; Quercetin promotes the reaction [mibolerone promotes the reaction [SP1 protein binds to AR protein]] CTD PMID:15661808 PMID:20148354 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO mibolerone results in increased expression of VEGFA mRNA CTD PMID:25846647 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      biological role 19815
        molecular messenger 18648
          hormone 18490
            anabolic agent 495
              mibolerone 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            heteroorganic entity 19492
                              organochalcogen compound 19255
                                organooxygen compound 19172
                                  carbonyl compound 18898
                                    ketone 17187
                                      oxo steroid 10541
                                        3-oxo steroid 9928
                                          3-oxo-Delta(4) steroid 9166
                                            mibolerone 20
paths to the root