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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-hydroxybutyric acid
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Accession:CHEBI:30830 term browser browse the term
Definition:A 4-hydroxy monocarboxylic acid that is butyric acid in which one of the hydrogens at position 4 is replaced by a hydroxy group.
Synonyms:related_synonym: 3-carboxypropoxy acid;   4-Hydroxyalkanoic acid;   4-Hydroxybutanoate;   4-Hydroxybutanoic acid;   4-Hydroxycarboxylic acid;   4-hydroxy-butyric acid;   Formula=C4H8O3;   GHB;   Gamma Hydroxybutyric Acid;   InChI=1S/C4H8O3/c5-3-1-2-4(6)7/h5H,1-3H2,(H,6,7);   InChIKey=SJZRECIVHVDYJC-UHFFFAOYSA-N;   SMILES=OCCCC(O)=O;   Xyrem;   oxy-n-butyric acid
 alt_id: CHEBI:1860;   CHEBI:20402;   CHEBI:386065
 xref: Beilstein:1720582;   CAS:591-81-1;   DrugBank:DB01440;   KEGG:C00989;   KEGG:C01991;   LIPID_MAPS_instance:LMFA01050006
 xref_mesh: MESH:C111420
 xref: PMID:15927467;   PMID:3361576;   Reaxys:1720582;   Wikipedia:Oxybate
 cyclic_relationship: is_conjugate_base_of CHEBI:16724


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4-hydroxybutyric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh5a1 aldhehyde dehydrogenase family 5, subfamily A1 increases abundance ISO
EXP		 ALDH5A1 mutant form results in increased abundance of 4-hydroxybutyric acid
ALDH5A1 gene mutant form results in increased abundance of 4-hydroxybutyric acid		 CTD PMID:17438226 PMID:29031482 NCBI chr13:25,091,562...25,121,740
Ensembl chr13:25,091,562...25,121,644 		JBrowse link
G Gh growth hormone multiple interactions
increases secretion		 ISO Cocaine inhibits the reaction [4-hydroxybutyric acid results in increased secretion of GH1 protein] CTD PMID:10657535 NCBI chr11:106,191,087...106,194,529
Ensembl chr11:106,191,097...106,192,691 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22210
    role 22195
      biological role 22194
        aetiopathogenetic role 21293
          neurotoxin 18830
            4-hydroxybutyric acid 2
              4-hydroxybutyryl-CoA 0
              mono(3-carboxypropyl) phthalate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22210
    subatomic particle 22202
      composite particle 22202
        hadron 22202
          baryon 22202
            nucleon 22202
              atomic nucleus 22202
                atom 22202
                  main group element atom 22136
                    p-block element atom 22136
                      carbon group element atom 21936
                        carbon atom 21861
                          organic molecular entity 21861
                            heteroorganic entity 21517
                              organochalcogen compound 21006
                                organooxygen compound 20847
                                  carbon oxoacid 19634
                                    carboxylic acid 19630
                                      monocarboxylic acid 19007
                                        fatty acid 17245
                                          short-chain fatty acid 16348
                                            fatty acid 4:0 8389
                                              butyric acid 6806
                                                hydroxybutyric acid 35
                                                  4-hydroxybutyric acid 2
                                                    4-hydroxybutyryl-CoA 0
                                                    mono(3-carboxypropyl) phthalate 0
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