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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:aflatoxin B1 exo-8,9-epoxide
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Accession:CHEBI:30725 term browser browse the term
Definition:An aflatoxin that has formula C17H12O7.
Synonyms:exact_synonym: (6aS,7aS,8aR,8bR)-4-methoxy-2,3,6a,7a,8a,8b-hexahydrocyclopenta[c]oxireno[4',5']furo[3',2':4,5]furo[2,3-h]chromene-1,10-dione
 related_synonym: 2,3-Epoxyaflatoxin B1;   Aflatoxin B1 2,3-epoxide;   Aflatoxin B1 8,9-epoxide;   Aflatoxin B1 exo-8,9-oxide;   Aflatoxin B1-2,3-oxide;   Formula=C17H12O7;   InChI=1S/C17H12O7/c1-20-7-4-8-11(12-14-17(23-14)24-16(12)21-8)13-10(7)5-2-3-6(18)9(5)15(19)22-13/h4,12,14,16-17H,2-3H2,1H3/t12-,14-,16+,17+/m1/s1;   InChIKey=KHBXRZGALJGBPA-IRWJRLHMSA-N;   SMILES=[H][C@@]12Oc3cc(OC)c4c5CCC(=O)c5c(=O)oc4c3[C@]1([H])[C@@]1([H])O[C@@]1([H])O2
 xref: CAS:42583-46-0;   KEGG:C19586
 xref_mesh: MESH:C006426


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aflatoxin B1 exo-8,9-epoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A2 protein results in increased metabolism of Aflatoxin B1] which results in increased chemical synthesis of aflatoxin B1-2,3-oxide CTD PMID:20707407 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Aflatoxin B1] which results in increased chemical synthesis of aflatoxin B1-2,3-oxide CTD PMID:20707407 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Gsta3 glutathione S-transferase alpha 3 multiple interactions EXP [GSTA3 protein binds to GSTA5 protein] which affects the metabolism of and results in decreased activity of aflatoxin B1-2,3-oxide CTD PMID:8051171 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions
affects metabolic processing		 EXP [GSTA3 protein binds to GSTA5 protein] which affects the metabolism of and results in decreased activity of aflatoxin B1-2,3-oxide; Butylated Hydroxyanisole promotes the reaction [GSTA5 protein affects the metabolism of aflatoxin B1-2,3-oxide]; Butylated Hydroxytoluene promotes the reaction [GSTA5 protein affects the metabolism of aflatoxin B1-2,3-oxide]; Ethoxyquin promotes the reaction [GSTA5 protein affects the metabolism of aflatoxin B1-2,3-oxide]; GSTA5 protein affects the metabolism of and results in decreased activity of aflatoxin B1-2,3-oxide; GSTA5 protein binds to and affects the metabolism of aflatoxin B1-2,3-oxide; Phenobarbital promotes the reaction [GSTA5 protein affects the metabolism of aflatoxin B1-2,3-oxide] CTD PMID:1637297 PMID:8051171 PMID:8198522 PMID:8625305 PMID:8761455 More... NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions EXP GSTM1 protein affects the metabolism of and results in decreased activity of aflatoxin B1-2,3-oxide CTD PMID:1638515 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects metabolic processing EXP GSTP1 protein affects the metabolism of aflatoxin B1-2,3-oxide CTD PMID:1638515 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19838
    role 19814
      biological role 19812
        poison 18614
          toxin 15979
            mycotoxin 12016
              aflatoxin 11151
                aflatoxin B1 exo-8,9-epoxide 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19786
                    p-block element atom 19786
                      carbon group element atom 19734
                        carbon atom 19731
                          organic molecular entity 19731
                            organic molecule 19684
                              organic cyclic compound 19496
                                organic heterocyclic compound 18874
                                  organic heteropolycyclic compound 18299
                                    organic heteropentacyclic compound 13512
                                      cyclopentafurofurochromene 11151
                                        aflatoxin 11151
                                          aflatoxin B1 exo-8,9-epoxide 6
paths to the root