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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Paraoxon-methyl
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Accession:CHEBI:165199 term browser browse the term
Synonyms:exact_synonym: dimethyl (4-nitrophenyl) phosphate
 related_synonym: Formula=C8H10NO6P;   InChI=1S/C8H10NO6P/c1-13-16(12,14-2)15-8-5-3-7(4-6-8)9(10)11/h3-6H,1-2H3;   InChIKey=BAFQDKPJKOLXFZ-UHFFFAOYSA-N;   SMILES=P(OC1=CC=C([N+]([O-])=O)C=C1)(OC)(OC)=O
 xref: CAS:950-35-6;   Chemspider:13114
 xref_mesh: MESH:C008480


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Paraoxon-methyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity
multiple interactions		 EXP
ISO		 methylparaoxon results in decreased activity of ACHE protein
4-(aminocarbonyl)-1-(3-(4-((E)-(hydroxyimino)methyl)pyridinium-1-yl)propyl)pyridinium dibromide inhibits the reaction [methylparaoxon results in decreased activity of ACHE protein]; asoxime chloride inhibits the reaction [methylparaoxon results in decreased activity of ACHE protein]; K-48 compound inhibits the reaction [methylparaoxon results in decreased activity of ACHE protein]; N,N'-monomethylenebis(pyridiniumaldoxime) inhibits the reaction [methylparaoxon results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [methylparaoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [methylparaoxon results in decreased activity of ACHE protein]		 CTD PMID:12478623 PMID:17265452 PMID:18761328 PMID:18804659 PMID:22982773 More... NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 multiple interactions
increases expression		 ISO AKR1C1 protein affects the susceptibility to [Benzo(a)pyrene co-treated with methylparaoxon]
methylparaoxon results in increased expression of AKR1C1 mRNA		 CTD PMID:19800895 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 multiple interactions
increases expression		 ISO AKR1C2 protein affects the susceptibility to [Benzo(a)pyrene co-treated with methylparaoxon]
methylparaoxon results in increased expression of AKR1C2 mRNA		 CTD PMID:19800895 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Alb albumin affects binding ISO methylparaoxon binds to ALB protein CTD PMID:15525694 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Bche butyrylcholinesterase affects activity
decreases activity		 ISO
EXP		 methylparaoxon affects the activity of BCHE protein
methylparaoxon results in decreased activity of BCHE protein		 CTD PMID:19428953 PMID:33497710 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO methylparaoxon results in increased expression of CDKN1A mRNA CTD PMID:18418871 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions		 ISO methylparaoxon results in increased expression of CYP1A1 mRNA
methylparaoxon inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]		 CTD PMID:19800895 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases chemical synthesis EXP CYP2C11 protein results in increased chemical synthesis of methylparaoxon CTD PMID:22271348 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases chemical synthesis EXP CYP3A23-3A1 protein results in increased chemical synthesis of methylparaoxon CTD PMID:22271348 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO methylparaoxon results in increased expression of GADD45A mRNA CTD PMID:18418871 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO methylparaoxon results in increased expression of MDM2 mRNA CTD PMID:18418871 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO methylparaoxon results in decreased expression of MKI67 protein CTD PMID:18418871 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions EXP
ISO		 [Calcium results in increased activity of PON1 protein] which results in decreased susceptibility to methylparaoxon; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to methylparaoxon CTD PMID:27132127 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Tp53 tumor protein p53 increases expression
affects activity		 ISO methylparaoxon results in increased expression of TP53 mRNA
methylparaoxon metabolite affects the activity of TP53 protein		 CTD PMID:18418871 PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19834
    chemical entity 19832
      group 19791
        inorganic group 19386
          nitro group 11132
            nitro compound 11132
              C-nitro compound 10858
                Paraoxon-methyl 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19834
    subatomic particle 19832
      composite particle 19832
        hadron 19832
          baryon 19832
            nucleon 19832
              atomic nucleus 19832
                atom 19832
                  main group element atom 19782
                    p-block element atom 19782
                      carbon group element atom 19731
                        carbon atom 19727
                          organic molecular entity 19727
                            organic molecule 19680
                              C-nitro compound 10858
                                Paraoxon-methyl 14
paths to the root