Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:acetone
go back to main search page
Accession:CHEBI:15347 term browser browse the term
Definition:A methyl ketone that consists of propane bearing an oxo group at C2.
Synonyms:exact_synonym: propan-2-one
 related_synonym: 2-Propanone;   Aceton;   Azeton;   Dimethyl ketone;   Dimethylketon;   Formula=C3H6O;   InChI=1S/C3H6O/c1-3(2)4/h1-2H3;   InChIKey=CSCPPACGZOOCGX-UHFFFAOYSA-N;   Propanon;   Pyroacetic ether;   SMILES=CC(C)=O;   beta-Ketopropane;   dimethylcetone;   dimethylketone;   methyl ketone;   propanone
 alt_id: CHEBI:13708;   CHEBI:22182;   CHEBI:2398;   CHEBI:40571
 xref: Beilstein:635680;   CAS:67-64-1;   Gmelin:1466;   HMDB:HMDB0001659;   KEGG:C00207;   KEGG:D02311;   LIPID_MAPS_instance:LMFA12000057
 xref_mesh: MESH:D000096
 xref: MetaCyc:ACETONE;   PDBeChem:ACN;   PMID:17190852;   PMID:17347819;   Reaxys:635680;   UM-BBD_compID:c0556;   Wikipedia:Acetone


show annotations for term's descendants           Sort by:
acetone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1 alcohol dehydrogenase 1 (class I) multiple interactions EXP [ADH1 protein results in increased oxidation of allyl alcohol] which results in increased abundance of Acetone CTD PMID:11981770 NCBI chr 3:137,983,346...137,996,459
Ensembl chr 3:137,966,752...137,996,459 		JBrowse link
G Cat catalase decreases activity ISO Acetone results in decreased activity of CAT protein CTD PMID:16169704 PMID:20127315 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO Acetone results in increased expression of CCND1 mRNA CTD PMID:12720008 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Acetone promotes the reaction [Toluene results in increased expression of CYP1A1 protein] CTD PMID:8996725 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression 		ISO Acetone promotes the reaction [Toluene results in increased expression of CYP1A2 protein]
acetone increased expression of Cyp1a2 protein in thoracic aorta of rats		 CTD
RGD		 PMID:8996725 PMID:12688525 RGD:401900656 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 multiple interactions ISO Acetone promotes the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide] CTD PMID:10611138 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression
increases activity
increases metabolic processing		 EXP
ISO		 [Acetone results in increased activity of CYP2E1 protein] which results in increased oxidation of Benzene; [Acetone results in increased expression of CYP2E1 protein] which results in increased susceptibility to allyl cyanide; Acetone results in increased expression of and results in increased activity of CYP2E1 protein
Acetone results in increased expression of CYP2E1 mRNA; Acetone results in increased expression of CYP2E1 protein
1,2-dichloroethylene inhibits the reaction [Acetone results in increased activity of CYP2E1 protein]; [Acetone co-treated with ciprofibrate] results in increased expression of CYP2E1 protein; [Acetone co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 mRNA; [Acetone co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 protein; [Acetone co-treated with Methylcholanthrene] results in increased activity of CYP2E1 protein; [Acetone co-treated with Methylcholanthrene] results in increased expression of CYP2E1 protein; Acetone promotes the reaction [2-xylene results in increased expression of CYP2E1 protein]; Acetone promotes the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]; Acetone promotes the reaction [Toluene results in increased expression of CYP2E1 protein]; Trichloroethylene inhibits the reaction [Acetone results in increased activity of CYP2E1 protein]
CYP2E1 protein results in increased metabolism of Acetone		 CTD PMID:1968335 PMID:2241968 PMID:3416296 PMID:3782137 PMID:7587954 More... NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 increases expression ISO Acetone results in increased expression of FGFR2 mRNA CTD PMID:12720008 NCBI chr 7:129,764,181...129,868,538
Ensembl chr 7:129,764,181...132,725,079 		JBrowse link
G Fn1 fibronectin 1 increases expression ISO Acetone results in increased expression of FN1 mRNA CTD PMID:33064461 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359 		JBrowse link
G Il13 interleukin 13 multiple interactions ISO [Acetone co-treated with Olive Oil] results in increased expression of IL13 mRNA CTD PMID:21252390 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO [Acetone co-treated with Olive Oil] results in increased expression of IL4 mRNA CTD PMID:21252390 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO [Acetone co-treated with Olive Oil] results in increased expression of IL5 mRNA CTD PMID:21252390 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933 		JBrowse link
G Itga5 integrin alpha 5 (fibronectin receptor alpha) increases expression ISO Acetone results in increased expression of ITGA5 mRNA CTD PMID:12720008 NCBI chr15:103,252,713...103,275,218
Ensembl chr15:103,252,713...103,275,190 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression EXP Acetone results in increased expression of NQO1 mRNA CTD PMID:9496914 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Acetone co-treated with Olive Oil] results in increased expression of TNF mRNA CTD PMID:21252390 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Trpm8 transient receptor potential cation channel, subfamily M, member 8 increases response to substance EXP TRPM8 protein results in increased susceptibility to Acetone CTD PMID:17481392 NCBI chr 1:88,234,457...88,318,909
Ensembl chr 1:88,205,383...88,317,015 		JBrowse link
aminoacetone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions ISO CAT protein results in decreased susceptibility to [aminoacetone co-treated with Copper] CTD PMID:18729331 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Gsr glutathione reductase multiple interactions ISO [aminoacetone co-treated with Copper] results in increased expression of GSR mRNA CTD PMID:18729331 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions ISO [aminoacetone co-treated with Copper] results in increased expression of SOD1 mRNA CTD PMID:18729331 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions ISO [aminoacetone co-treated with Copper] results in increased expression of SOD2 mRNA CTD PMID:18729331 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    role 22179
      application 21764
        solvent 18234
          polar solvent 16287
            polar aprotic solvent 642
              acetone 19
                1-hydroxy-3-methoxyacetone 0
                2-oxopropylidene group 0
                2-oxopropylidyne group 0
                acetonyl group 0
                aminoacetone 4
                bromoacetone 0
                chloroacetone 0
                hydroxyacetone + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    p-block element atom 22120
                      carbon group element atom 21921
                        carbon atom 21847
                          organic molecular entity 21847
                            heteroorganic entity 21503
                              organochalcogen compound 20992
                                organooxygen compound 20834
                                  carbon oxoacid 19625
                                    carboxylic acid 19621
                                      monocarboxylic acid 18999
                                        fatty acid 17244
                                          fatty acid derivative 9018
                                            ketone body 24
                                              acetone 19
                                                1-hydroxy-3-methoxyacetone 0
                                                2-oxopropylidene group 0
                                                2-oxopropylidyne group 0
                                                acetonyl group 0
                                                aminoacetone 4
                                                bromoacetone 0
                                                chloroacetone 0
                                                hydroxyacetone + 0
paths to the root