CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: sophoranone
Accession: CHEBI:9199
browse the term
Definition: A dihydroxyflavanone that is (2S)-flavanone substituted by hydroxy groups at positions 7 and 4' and prenyl groups at positions 3' and 5' respectively.
Synonyms: related_synonym: (2S)-7-hydroxy-2-[4-hydroxy-3,5-bis(3-methylbut-2-en-1-yl)phenyl]-8-(3-methylbut-2-en-1-yl)-2,3-dihydro-4H-1-benzopyran-4-one; Formula=C30H36O4; InChI=1S/C30H36O4/c1-18(2)7-10-21-15-23(16-22(29(21)33)11-8-19(3)4)28-17-27(32)25-13-14-26(31)24(30(25)34-28)12-9-20(5)6/h7-9,13-16,28,31,33H,10-12,17H2,1-6H3/t28-/m0/s1; InChIKey=IORSRBKNYXPSDO-NDEPHWFRSA-N; SMILES=CC(C)=CCc1cc(cc(CC=C(C)C)c1O)[C@@H]1CC(=O)c2ccc(O)c(CC=C(C)C)c2O1
xref: CAS:23057-55-8; KEGG:C08719; KNApSAcK:C00001005; LIPID_MAPS_instance:LMPK12140034
xref_mesh: MESH:C461819
xref: PMID:12115492; PMID:24345512; PMID:26068519; Reaxys:1332986
G
Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
decreases activity
ISO
sophoranone results in decreased activity of CYP2C19 protein
CTD
PMID:29753067
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
G
Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
decreases activity
ISO
sophoranone results in decreased activity of CYP2D6 protein
CTD
PMID:29753067
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases activity
ISO
sophoranone results in decreased activity of CYP3A4 protein
CTD
PMID:29753067
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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